Multivitamin Kompleksleri
Özet
Multivitamin kompkleksleri tüm dünyada potansiyel sağlık faydaları nedeniyle yaygın olarak kullanılmaktadır. Yapılan çalışmalarda kanser hastalarının %80’inin multivitamin ve/veya mineral takviyesi aldığı gözlenmiştir. Kanser hastalarında yapılan birkaç çalışmada özelliki hasta gruplarında az da olsa mortalitede azalma gösterilmişse de genel olarak bu takviyelerin kullanımının kanser mortalite ve yaşam kalitesine ek katkısı bulunamamıştır.
Multivitamin supplements are widely used all over the world for their potantiel health benefits. Studies have shown that 80% of cancer patients take multivitamin and/or mineral supplements. Although a few studies on the effect of multivitamin use on disease in cancer patients have shown a small reduction in mortality in specific patient groups, in general, the use of theese supplements has not been found to contrribute to cancer mortality and quality of life.
Referanslar
1.Han-Yao Huang , Benjamin Caballero, Stephanie Chang,et al. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Ann Intern Med, 2006 Sep 5;145(5):372-85. doi: 10.7326/0003-4819-145-5-200609050-00135.
2.A J Gescher , R A Sharma, W P Steward,et al. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol,Volume 2, Issue 6, June 2001, Pages 371-379. doi: 10.1016/S1470-2045(00)00392-2.
3.Elizabeth A O'Connor , Corinne V Evans , Ilya Ivlev, et al. Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 2022 Jun 21;327(23):2334-2347.doi: 10.1001/jama.2021.15650.
4.Karla A Lawson , Margaret E Wright, Amy Subar, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst, 2007 May 16;99(10):754-64. doi: 10.1093/jnci/djk177.
5.Victoria L Stevens, Marjorie L McCullough, W Ryan Diver, et al. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control, 2005 Aug;16(6):643-50.
doi: 10.1007/s10552-005-0384-5.
6.Sarah Nechuta, Wei Lu, Zhi Chen, et al. Vitamin Supplement Use During Breast Cancer Treatment and Survival: A Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev ,(2011) 20 (2): 262–271. https://doi.org/10.1158/1055-9965.EPI-10-1072
7.Christine B. Ambrosone, Gary R. Zirpoli, et al. Alan D. Hutson. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). J Clin Oncol,.2020 Mar 10; 38(8): 804–814. doi: 10.1200/JCO.19.01203.
8.M.L. Lesperance, I.A. Olivotto, N. Forde et al. Mega-Dose Vitamins and Minerals in the Treatment of Non-Metastatic Breast Cancer: An Historical Cohort Study. Breast Cancer Research and Treatment ,2022 volume 76, p. 137–143.
9.Kwan ML, Greenlee H, Lee VS, et al. Multivitamin use and breast cancer outcomes in women with early-stage breast cancer: the Life After Cancer Epidemiology study. Breast Cancer Res Treat. 2011;130:195-205.
S Wassertheil-Smoller , A P McGinn, N Budrys, et al. Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the women's health initiative. Breast Cancer Res Treat. 2013 Oct;141(3):495-505. doi: 10.1007/s10549-013-2712-x. Epub 2013 Oct 9.
Aminah Jatoi 1, Brent Williams, Frank Nichols,et al. Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients? Results from the Mayo Clinic lung cancer cohort. Lung Cancer, 2005 Jul;49(1):77-84. doi: 10.1016/j.lungcan.2005.01.004.
Aminah Jatoi , Brent A Williams, Randolph Marks, et al. Exploring vitamin and mineral supplementation and purported clinical effects in patients with small cell lung cancer: results from the Mayo Clinic lung cancer cohort. Nutr Cancer, 2005;51(1):7-12. doi: 10.1207/s15327914nc5101_2.
13.Jin-Hu Fan 1, Jian-Bing Wang 2, Huan Yang, et al. Mortality after multivitamin supplementation: Nearly 35-year follow-up of the randomized Linxian Dysplasia Nutrition Intervention Trial. Cancer, 2022 Aug 1;128(15):2939-2948. doi: 10.1002/cncr.34344.
Jessica C Goodwin , Qichen Wang , Pao-Hwa Lin, Supplement use and gastric cancer risk in the Southern Community Cohort Study. Cancer Causes Control, 2023 Oct;34(10):897-907. doi: 10.1007/s10552-023-01734-7.
15 Sonja P. Dawsey, Albert Hollenbeck, Arthur Schatzkin, et al. A Prospective Study of Vitamin and Mineral Supplement Use and the Risk of Upper Gastrointestinal Cancers. PLoS, One 2014 Feb 18;9(2):e88774. doi: 10.1371/journal.pone.0088774.
16 Eric J. Jacobs; Cari J. Connell; Marjorie L. McCullough, et al. Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort. Cancer Epidemiol Biomarkers Prev, 2002 Jan;11(1):35-41.
Kimmie Ng, Jeffrey A Meyerhardt, Jennifer A Chan, et al. Multivitamin use is not associated with cancer recurrence or survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol, 2010 Oct 1;28(28):4354-63. doi: 10.1200/JCO.2010.28.0362.
Perrone G, Hideshima T, Ikeda H, et al, “Ascorbic Acid Inhibits Antitumor Activity of Bortezomib in Vivo,” Leukemia, 2009, 23:1679-86. doi: 10.1038/leu.2009.83
Zou W, Yue P, Lin N, et al, “Vitamin C Inactivates the Proteasome Inhibitor PS-341 in Human Cancer Cells,” Clin Cancer Res, 2006, 12:273-80. doi: 10.1158/1078-0432.CCR-05-0503.
Christine M Velicer , Cornelia M Ulrich,et al. Vitamin and Mineral Supplement Use Among US Adults After Cancer Diagnosis: A Systematic Review .J Clin Oncol. 2008 Feb 1;26(4):665-73. doi: 10.1200/JCO.2007.13.5905.
Doyle C, Kushi LH, Byers T,et al. Nutrition and physical activity during and after cancer treatment: An American Cancer Society guide for informed choices. CA Cancer J Clin, 2006 Nov-Dec;56(6):323-53. doi: 10.3322/canjclin.56.6.323.
Macpherson H, Pipingas A, Pase MP. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 2013 Feb;97(2):437-44. doi: 10.3945/ajcn.112.049304.
2.A J Gescher , R A Sharma, W P Steward,et al. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol,Volume 2, Issue 6, June 2001, Pages 371-379. doi: 10.1016/S1470-2045(00)00392-2.
3.Elizabeth A O'Connor , Corinne V Evans , Ilya Ivlev, et al. Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 2022 Jun 21;327(23):2334-2347.doi: 10.1001/jama.2021.15650.
4.Karla A Lawson , Margaret E Wright, Amy Subar, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst, 2007 May 16;99(10):754-64. doi: 10.1093/jnci/djk177.
5.Victoria L Stevens, Marjorie L McCullough, W Ryan Diver, et al. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control, 2005 Aug;16(6):643-50.
doi: 10.1007/s10552-005-0384-5.
6.Sarah Nechuta, Wei Lu, Zhi Chen, et al. Vitamin Supplement Use During Breast Cancer Treatment and Survival: A Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev ,(2011) 20 (2): 262–271. https://doi.org/10.1158/1055-9965.EPI-10-1072
7.Christine B. Ambrosone, Gary R. Zirpoli, et al. Alan D. Hutson. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). J Clin Oncol,.2020 Mar 10; 38(8): 804–814. doi: 10.1200/JCO.19.01203.
8.M.L. Lesperance, I.A. Olivotto, N. Forde et al. Mega-Dose Vitamins and Minerals in the Treatment of Non-Metastatic Breast Cancer: An Historical Cohort Study. Breast Cancer Research and Treatment ,2022 volume 76, p. 137–143.
9.Kwan ML, Greenlee H, Lee VS, et al. Multivitamin use and breast cancer outcomes in women with early-stage breast cancer: the Life After Cancer Epidemiology study. Breast Cancer Res Treat. 2011;130:195-205.
S Wassertheil-Smoller , A P McGinn, N Budrys, et al. Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the women's health initiative. Breast Cancer Res Treat. 2013 Oct;141(3):495-505. doi: 10.1007/s10549-013-2712-x. Epub 2013 Oct 9.
Aminah Jatoi 1, Brent Williams, Frank Nichols,et al. Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients? Results from the Mayo Clinic lung cancer cohort. Lung Cancer, 2005 Jul;49(1):77-84. doi: 10.1016/j.lungcan.2005.01.004.
Aminah Jatoi , Brent A Williams, Randolph Marks, et al. Exploring vitamin and mineral supplementation and purported clinical effects in patients with small cell lung cancer: results from the Mayo Clinic lung cancer cohort. Nutr Cancer, 2005;51(1):7-12. doi: 10.1207/s15327914nc5101_2.
13.Jin-Hu Fan 1, Jian-Bing Wang 2, Huan Yang, et al. Mortality after multivitamin supplementation: Nearly 35-year follow-up of the randomized Linxian Dysplasia Nutrition Intervention Trial. Cancer, 2022 Aug 1;128(15):2939-2948. doi: 10.1002/cncr.34344.
Jessica C Goodwin , Qichen Wang , Pao-Hwa Lin, Supplement use and gastric cancer risk in the Southern Community Cohort Study. Cancer Causes Control, 2023 Oct;34(10):897-907. doi: 10.1007/s10552-023-01734-7.
15 Sonja P. Dawsey, Albert Hollenbeck, Arthur Schatzkin, et al. A Prospective Study of Vitamin and Mineral Supplement Use and the Risk of Upper Gastrointestinal Cancers. PLoS, One 2014 Feb 18;9(2):e88774. doi: 10.1371/journal.pone.0088774.
16 Eric J. Jacobs; Cari J. Connell; Marjorie L. McCullough, et al. Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort. Cancer Epidemiol Biomarkers Prev, 2002 Jan;11(1):35-41.
Kimmie Ng, Jeffrey A Meyerhardt, Jennifer A Chan, et al. Multivitamin use is not associated with cancer recurrence or survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol, 2010 Oct 1;28(28):4354-63. doi: 10.1200/JCO.2010.28.0362.
Perrone G, Hideshima T, Ikeda H, et al, “Ascorbic Acid Inhibits Antitumor Activity of Bortezomib in Vivo,” Leukemia, 2009, 23:1679-86. doi: 10.1038/leu.2009.83
Zou W, Yue P, Lin N, et al, “Vitamin C Inactivates the Proteasome Inhibitor PS-341 in Human Cancer Cells,” Clin Cancer Res, 2006, 12:273-80. doi: 10.1158/1078-0432.CCR-05-0503.
Christine M Velicer , Cornelia M Ulrich,et al. Vitamin and Mineral Supplement Use Among US Adults After Cancer Diagnosis: A Systematic Review .J Clin Oncol. 2008 Feb 1;26(4):665-73. doi: 10.1200/JCO.2007.13.5905.
Doyle C, Kushi LH, Byers T,et al. Nutrition and physical activity during and after cancer treatment: An American Cancer Society guide for informed choices. CA Cancer J Clin, 2006 Nov-Dec;56(6):323-53. doi: 10.3322/canjclin.56.6.323.
Macpherson H, Pipingas A, Pase MP. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 2013 Feb;97(2):437-44. doi: 10.3945/ajcn.112.049304.
Sayfalar
439-442
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Türkoğlu E. Multivitamin Kompleksleri. Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 439-42. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/14014
