B12 Vitamini (Kobalamin)

Özet

Bu bölüm, risk, tedavi ve ilaç etkileşimleriyle ilgili hususları kapsayan, kanser bağlamında B12 vitamininin rolünün kapsamlı bir incelemesini sunmaktadır. Kanser hastaları arasında B12 takviyesi de dahil olmak üzere tamamlayıcı ve alternatif tıp kullanımı yaygındır. Ancak etkinliği ve güvenliğine ilişkin kanıtlar kanser türleri arasında heterojendir. İnceleme, B12'nin çeşitli kanserler üzerindeki etkisini doğru bir şekilde belirlemek için titiz randomize kontrollü çalışmalara duyulan ihtiyacı vurgulayarak mevcut çalışmalardan elde edilen bulguları sentezliyor.

This chapter provides a comprehensive review of the role of vitamin B12 in the context of cancer, covering considerations of risk, treatment, and drug interactions. Use of complementary and alternative medicine, including B12 supplements, is common among cancer patients. However, evidence regarding its effectiveness and safety is heterogeneous across cancer types. The review synthesizes findings from existing studies, highlighting the need for rigorous randomized controlled trials to accurately determine the effect of B12 on various cancers.

Referanslar

; Available from: National Cancer Institute. Complementary and alternative medicine (CAM). Accessed November 11, 2022, https://www.cancer.gov/about-cancer/treatment/cam.
Mishra, S., et al., Dietary Supplement Use Among Adults: United States, 2017-2018. NCHS Data Brief, 2021(399): p. 1-8.
Clarke, T.C., The Use of Complementary Health Approaches Among U.S. Adults with a Recent Cancer Diagnosis. J Altern Complement Med, 2018. 24(2): p. 139-145.
Gansler, T., et al., A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society's studies of cancer survivors. Cancer, 2008. 113(5): p. 1048-57.
Moyer, V.A., Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive services Task Force recommendation statement. Ann Intern Med, 2014. 160(8): p. 558-64.
Clinton, S.K., E.L. Giovannucci, and S.D. Hursting, The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. J Nutr, 2020. 150(4): p. 663-671.
Rock, C.L., et al., Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin, 2012. 62(4): p. 243-74.
Harvie, M., Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book, 2014: p. e478-86.
Hübner, J., et al., Complementary Medicine in the Treatment of Cancer Patients. Dtsch Arztebl Int, 2021. 118(39): p. 654-659.
Liu, Y., et al., Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies. Med Oncol, 2015. 32(1): p. 434.
Liu, Y., et al., Vitamin B2 intake and the risk of colorectal cancer: a meta-analysis of observational studies. Asian Pac J Cancer Prev, 2015. 16(3): p. 909-13.
Peterson, C.T., et al., B Vitamins and Their Role in Immune Regulation and Cancer. Nutrients, 2020. 12(11).
Kim, S.J., et al., Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study. Breast Cancer Res Treat, 2019. 174(3): p. 741-748.
Miranti, E.H., et al., Low vitamin B(12) increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer. Int J Cancer, 2017. 141(6): p. 1120-1129.
Brasky, T.M., E. White, and C.L. Chen, Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol, 2017. 35(30): p. 3440-3448.
Khairan, P., et al., Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer, 2021. 21(1): p. 982.
Han, X., et al., Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer, 2017. 17(1): p. 40.
Oliai Araghi, S., et al., Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial. Cancer Epidemiol Biomarkers Prev, 2019. 28(2): p. 275-282.
Van de Roovaart, H.J., et al., Safety and efficacy of vitamin B in cancer treatments: A systematic review. J Oncol Pharm Pract, 2023: p. 10781552231178686.
Medscape. Drug Interaction Checker. https://reference.medscape.com/drug/vitamin-b12-nascobal-cyanocobalamin-344418#6.

Yayınlanan

11 Mart 2024

Lisans

Lisans

Nasıl Atıf Yapılır

1.
Akdağ G. B12 Vitamini (Kobalamin). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 425-8. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/14011