B6 Vitamini (Pridoksin)
Synopsis
Geleneksel ve tamamlayıcı tıp kullanım oranlarının artmasıyla birlikte, alternatif tıbbın onkoloji tedavilerine entegrasyonunun araştırılması giderek yaygınlaşmaktadır. B vitamini bileşiklerinin tamamının da kanserin önlenmesi, tedavisi ve yan etki yönetiminde potansiyel olarak faydalı olduğu öne sürülmüştür; ancak birçok çalışma, B vitaminlerinin onkolojideki kullanımına ilişkin çelişkili kanıtlar içermektedir. B6 vitamini (piridoksin) de bu alanda sık araştırılan bir molekül olup kanser üzerine etkileri hala tartışmalıdır. Bu bölümde de B6 vitaminin kanser riski, tedavisi ve ilaç etkileşimleri üzerine olan olumlu ve olumsuz sonuçları tıbbi kanıtlar eşliğinde derlenerek özetlenmeye çalışılmıştır.
With the increasing use of traditional and complementary medicine, it is becoming increasingly common to investigate the integration of alternative medicine into oncology treatments. All vitamin B compounds have also been suggested to be potentially useful in the prevention, treatment, and side-effect management of cancer; however, many studies contain conflicting evidence regarding the use of B vitamins in oncology. Vitamin B6 (pyridoxine) is a molecule frequently researched in this field, but its effects on cancer are still controversial. In this section, the positive and negative consequences of vitamin B6 on cancer risk, treatment and drug interactions have been compiled and summarized with medical evidence.
References
Shibata K, Yasuhara Y, Yasuda K. Effects of cooking methods on the retention of vitamin B6 in foods, and the approximate cooking loss in daily meals. Journal of Home Economics of Japan. 2001;52(12):1187-97.
Lassen A, Kall M, Hansen K, Ovesen L. A comparison of the retention of vitamins B1, B2 and B6, and cooking yield in pork loin with conventional and enhanced meal-service systems. European Food Research and Technology. 2002;215:194-9.
Peterson CT, Rodionov DA, Osterman AL, Peterson SN. B vitamins and their role in immune regulation and cancer. Nutrients. 2020;12(11):3380.
Rail LC, Meydani SN. Vitamin B6 and immune competence. Nutrition Reviews. 1993;51(8):217-25.
Leklem JE. Vitamin B-6: a status report. The Journal of Nutrition. 1990;120:1503-7.
Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. The Journal of American Medical Association. 1998;279(5):359-64.
Ghavanini AA, Kimpinski K. Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. Journal of Clinical Neuromuscular Disease. 2014;16(1):25-31.
Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. European Journal of Emergency Medicine. 2005;12(2):78-85.
Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Institute of Medicine (US) . Food, Nutrition Board. : National Academy Press Washington, DC; 2000.
Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients. 2021;13(9):3229.
Mikkelsen K, Prakash MD, Kuol N, Nurgali K, Stojanovska L, Apostolopoulos V. Anti-tumor effects of vitamin B2, B6 and B9 in promonocytic lymphoma cells. International Journal of Molecular Sciences. 2019;20(15):3763.
Yuan J, Li J, Shang M, Fu Y, Wang T. Identification of vitamin B6 as a PD-L1 suppressor and an adjuvant for cancer immunotherapy. Biochemical and Biophysical Research Communications. 2021;561:187-94.
Galluzzi L, Vacchelli E, Michels J, Garcia P, Kepp O, Senovilla L, et al. Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses. Oncogene. 2013;32(42):4995-5004.
Mocellin S, Briarava M, Pilati P. Vitamin B6 and cancer risk: a field synopsis and meta-analysis. Journal of the National Cancer Institute. 2017;109(3):1-9.
Zuo H, Ueland PM, Midttun Ø, Tell GS, Fanidi A, Zheng W, et al. Vitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3). Annals of Oncology. 2019;30(3):478-85.
Gylling B, Myte R, Schneede J, Hallmans G, Häggström J, Johansson I, et al. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status. The American Journal of Clinical Nutrition. 2017;105(4):897-904.
Kayashima T, Tanaka K, Okazaki Y, Matsubara K, Yanaka N, Kato N. Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1, 2-dimethylhydrazine. Oncology Letters. 2011;2(6):1243-6.
Lee JE, Li H, Giovannucci E, Lee IM, Selhub J, Stampfer M, et al. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiology Biomarkers & Prevention. 2009;18(4):1197-202.
Van de Roovaart H, Stevens M, Goodridge A, Baden K, Sibbitt B, Delaney E, et al. Safety and efficacy of vitamin B in cancer treatments: A systematic review. Journal of Oncology Pharmacy Practice. 2023:10781552231178686-.
Brasky TM, White E, Chen CL. Long-term, supplemental, one-carbon metabolism–related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. Journal of Clinical Oncology. 2017;35(30):3440.
Antwi SO, Petrick JL, Campbell PT, Norez DA, Stevens VL, Liao LM, et al. One‐carbon metabolism‐related micronutrients intake and risk for hepatocellular carcinoma: a prospective cohort study. International Journal of Cancer. 2020;147(8):2075-90.
Brasky TM, Ray RM, Navarro SL, Schenk JM, Newton AM, Neuhouser ML. Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women's Health Initiative. International Journal of Cancer. 2020;147(5):1374-84.
Zeng Ff, Liu Yt, Lin Xl, Fan Yy, Zhang Xl, Xu Ch, et al. Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case–control study. British Journal of Nutrition. 2016;115(1):121-8.
Li H, Chen M, Liang S, Wei X, Wang R, Cui C, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clinical Nutrition. 2021;40(4):2293-300.
Cheng SB, Lin PT, Liu HT, Peng YS, Huang SC, Huang YC. Vitamin B-6 supplementation could mediate antioxidant capacity by reducing plasma homocysteine concentration in patients with hepatocellular carcinoma after tumor resection. BioMed Research International. 2016;2016:7658981.
Toyama T, Yoshimura A, Hayashi T, Kobayashi N, Saito K, Tsuneizumi M, et al. A randomized phase II study evaluating pyridoxine for the prevention of hand–foot syndrome associated with capecitabine therapy for advanced or metastatic breast cancer. Breast Cancer. 2018;25:729-35.
Chen M, Zhang L, Wang Q, Shen J. Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy: a systematic review. PLoS One. 2013;8(8):e72245.
Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ, et al. Association of the B-vitamins pyridoxal 5′-phosphate (B6), B12, and folate with lung cancer risk in older men. American Journal of Epidemiology. 2001;153(7):688-94.
Okazaki Y, Utama Z, Suidasari S, Zhang P, Yanaka N, Tomotake H, et al. Consumption of vitamin B6 reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet. Journal of Nutritional Science and Vitaminology. 2012;58(5):366-70.
Clasen JL, Heath AK, Scelo G, Muller DC. Components of one-carbon metabolism and renal cell carcinoma: A systematic review and meta-analysis. European Journal of Nutrition. 2020;59:3801-13.
Zeng J, Gu Y, Fu H, Liu C, Zou Y, Chang H. Association between one-carbon metabolism-related vitamins and risk of breast cancer: A systematic review and meta-analysis of prospective studies. Clinical Breast Cancer. 2020;20(4):e469-e80.
Qiang Y, Li Q, Xin Y, Fang X, Tian Y, Ma J, et al. Intake of dietary one-carbon metabolism-related B vitamins and the risk of esophageal cancer: a dose-response meta-analysis. Nutrients. 2018;10(7):835.
Aranda F, Bloy N, Pesquet J, Petit B, Chaba K, Sauvat A, et al. Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer. Oncogene. 2015;34(23):3053-62.
Machover D, Almohamad W, Castagné V, Desterke C, Gomez L, Gaston-Mathé Y, et al. Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas. Scientific Reports. 2021;11(1):12668.
Machover D, Goldschmidt E, Almohamad W, Castagné V, Dairou J, Desterke C, et al. Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma. Scientific Reports. 2022;12(1):9079.
Ezzo DC. Drug interactions with vitamins and minerals. US Pharm. 2007;1:42-55.
Leon AS, Spiegel HE, Thomas G, Abrams WB. Pyridoxine antagonism of levodopa in parkinsonism. The Journal of American Medical Association.. 1971;218(13):1924-7.
Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. The Lancet. 1976;307(7953):256.
St. Luke's Hospital. Possible Interactions with: Vitamin B6 (Pyridoxine). [Available from: https://www.stlukes-stl.com/health-content/medicine/33/000992.htm] (Accessed 30th November 2023)
Lassen A, Kall M, Hansen K, Ovesen L. A comparison of the retention of vitamins B1, B2 and B6, and cooking yield in pork loin with conventional and enhanced meal-service systems. European Food Research and Technology. 2002;215:194-9.
Peterson CT, Rodionov DA, Osterman AL, Peterson SN. B vitamins and their role in immune regulation and cancer. Nutrients. 2020;12(11):3380.
Rail LC, Meydani SN. Vitamin B6 and immune competence. Nutrition Reviews. 1993;51(8):217-25.
Leklem JE. Vitamin B-6: a status report. The Journal of Nutrition. 1990;120:1503-7.
Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. The Journal of American Medical Association. 1998;279(5):359-64.
Ghavanini AA, Kimpinski K. Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. Journal of Clinical Neuromuscular Disease. 2014;16(1):25-31.
Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. European Journal of Emergency Medicine. 2005;12(2):78-85.
Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Institute of Medicine (US) . Food, Nutrition Board. : National Academy Press Washington, DC; 2000.
Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients. 2021;13(9):3229.
Mikkelsen K, Prakash MD, Kuol N, Nurgali K, Stojanovska L, Apostolopoulos V. Anti-tumor effects of vitamin B2, B6 and B9 in promonocytic lymphoma cells. International Journal of Molecular Sciences. 2019;20(15):3763.
Yuan J, Li J, Shang M, Fu Y, Wang T. Identification of vitamin B6 as a PD-L1 suppressor and an adjuvant for cancer immunotherapy. Biochemical and Biophysical Research Communications. 2021;561:187-94.
Galluzzi L, Vacchelli E, Michels J, Garcia P, Kepp O, Senovilla L, et al. Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses. Oncogene. 2013;32(42):4995-5004.
Mocellin S, Briarava M, Pilati P. Vitamin B6 and cancer risk: a field synopsis and meta-analysis. Journal of the National Cancer Institute. 2017;109(3):1-9.
Zuo H, Ueland PM, Midttun Ø, Tell GS, Fanidi A, Zheng W, et al. Vitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3). Annals of Oncology. 2019;30(3):478-85.
Gylling B, Myte R, Schneede J, Hallmans G, Häggström J, Johansson I, et al. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status. The American Journal of Clinical Nutrition. 2017;105(4):897-904.
Kayashima T, Tanaka K, Okazaki Y, Matsubara K, Yanaka N, Kato N. Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1, 2-dimethylhydrazine. Oncology Letters. 2011;2(6):1243-6.
Lee JE, Li H, Giovannucci E, Lee IM, Selhub J, Stampfer M, et al. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiology Biomarkers & Prevention. 2009;18(4):1197-202.
Van de Roovaart H, Stevens M, Goodridge A, Baden K, Sibbitt B, Delaney E, et al. Safety and efficacy of vitamin B in cancer treatments: A systematic review. Journal of Oncology Pharmacy Practice. 2023:10781552231178686-.
Brasky TM, White E, Chen CL. Long-term, supplemental, one-carbon metabolism–related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. Journal of Clinical Oncology. 2017;35(30):3440.
Antwi SO, Petrick JL, Campbell PT, Norez DA, Stevens VL, Liao LM, et al. One‐carbon metabolism‐related micronutrients intake and risk for hepatocellular carcinoma: a prospective cohort study. International Journal of Cancer. 2020;147(8):2075-90.
Brasky TM, Ray RM, Navarro SL, Schenk JM, Newton AM, Neuhouser ML. Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women's Health Initiative. International Journal of Cancer. 2020;147(5):1374-84.
Zeng Ff, Liu Yt, Lin Xl, Fan Yy, Zhang Xl, Xu Ch, et al. Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case–control study. British Journal of Nutrition. 2016;115(1):121-8.
Li H, Chen M, Liang S, Wei X, Wang R, Cui C, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clinical Nutrition. 2021;40(4):2293-300.
Cheng SB, Lin PT, Liu HT, Peng YS, Huang SC, Huang YC. Vitamin B-6 supplementation could mediate antioxidant capacity by reducing plasma homocysteine concentration in patients with hepatocellular carcinoma after tumor resection. BioMed Research International. 2016;2016:7658981.
Toyama T, Yoshimura A, Hayashi T, Kobayashi N, Saito K, Tsuneizumi M, et al. A randomized phase II study evaluating pyridoxine for the prevention of hand–foot syndrome associated with capecitabine therapy for advanced or metastatic breast cancer. Breast Cancer. 2018;25:729-35.
Chen M, Zhang L, Wang Q, Shen J. Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy: a systematic review. PLoS One. 2013;8(8):e72245.
Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ, et al. Association of the B-vitamins pyridoxal 5′-phosphate (B6), B12, and folate with lung cancer risk in older men. American Journal of Epidemiology. 2001;153(7):688-94.
Okazaki Y, Utama Z, Suidasari S, Zhang P, Yanaka N, Tomotake H, et al. Consumption of vitamin B6 reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet. Journal of Nutritional Science and Vitaminology. 2012;58(5):366-70.
Clasen JL, Heath AK, Scelo G, Muller DC. Components of one-carbon metabolism and renal cell carcinoma: A systematic review and meta-analysis. European Journal of Nutrition. 2020;59:3801-13.
Zeng J, Gu Y, Fu H, Liu C, Zou Y, Chang H. Association between one-carbon metabolism-related vitamins and risk of breast cancer: A systematic review and meta-analysis of prospective studies. Clinical Breast Cancer. 2020;20(4):e469-e80.
Qiang Y, Li Q, Xin Y, Fang X, Tian Y, Ma J, et al. Intake of dietary one-carbon metabolism-related B vitamins and the risk of esophageal cancer: a dose-response meta-analysis. Nutrients. 2018;10(7):835.
Aranda F, Bloy N, Pesquet J, Petit B, Chaba K, Sauvat A, et al. Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer. Oncogene. 2015;34(23):3053-62.
Machover D, Almohamad W, Castagné V, Desterke C, Gomez L, Gaston-Mathé Y, et al. Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas. Scientific Reports. 2021;11(1):12668.
Machover D, Goldschmidt E, Almohamad W, Castagné V, Dairou J, Desterke C, et al. Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma. Scientific Reports. 2022;12(1):9079.
Ezzo DC. Drug interactions with vitamins and minerals. US Pharm. 2007;1:42-55.
Leon AS, Spiegel HE, Thomas G, Abrams WB. Pyridoxine antagonism of levodopa in parkinsonism. The Journal of American Medical Association.. 1971;218(13):1924-7.
Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. The Lancet. 1976;307(7953):256.
St. Luke's Hospital. Possible Interactions with: Vitamin B6 (Pyridoxine). [Available from: https://www.stlukes-stl.com/health-content/medicine/33/000992.htm] (Accessed 30th November 2023)
Pages
419-424
Published
March 11, 2024
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Sünger E. B6 Vitamini (Pridoksin). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 419-24. Available from: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13999
