Kefir Ve Kanser
Synopsis
Kefir, yararlı probiyotikler içeren, maya ve bakterilerin eşsiz bir fermantasyon ürünüdür. Dünyanın farklı yerlerinden gelen kefir tanelerinin farklı faydalara sahip olduğu gözlemlenmiştir. Dengesiz mikrobiyal yapı disbiyozis olarak tanımlanır. Son on yılda disbiyoz üzerine birçok çalışma yapılmıştır. Disbiyozun probiyotik tüketimi ile aşılabileceği düşünülerek çalışma deneklerinde kefir ve diğer probiyotiklerin önemi vurgulanmıştır. Kefirin antioksidan, antitümör, apoptotik, antimetastatik, immünomodülatör ve nöroprotektif özelliklere sahip olduğunu gösteren çalışmalar yapılmıştır. Tüm bu çalışmalardan elde edilen sonuçlarda Bcl-2, MMP ve TGF-α'da azalma; kaspaz-3, p53, TGF-β1, Bax:Bcl-2 oranı, Bax ve p21'de artışlar; Antiinflamatuar hücreler olan Treg hücrelerini düzenleyerek bu anti-kanser etkilerini oluşturduğu düşünülmektedir. Birçok probiyotik, pazarlamadan önce Amerika Birleşik Devletleri Gıda ve İlaç İdaresi'nin (FDA) onayını gerektirmeyen besin takviyesi olarak satılmaktadır. Kefir, FDA tarafından kanser ilacı veya kanser önleyici ilaç olarak onaylanmamıştır. Güncel onkoloji kılavuzlarında tedavi veya destek tedavisinin yer almadığı unutulmamalıdır.
Kefir is a unique fermentation product of yeast and bacteria that contains beneficial probiotics. It has been observed that kefir grains from different parts of the world have different benefits. Unbalanced microbial structure is defined as dysbiosis. Many studies have been conducted on dysbiosis in the last decade. Considering that dysbiosis can be overcome with probiotic consumption, the importance of kefir and other probiotics was emphasized in the study subjects. Studies have been conducted showing that kefir has antioxidant, antitumor, apoptotic, antimetastatic, immunomodulatory and neuroprotective properties. In the results obtained from all these studies, decreases in Bcl-2, MMP and TGF-α; increases in caspase-3, p53, TGF-β1, Bax:Bcl-2 ratio, Bax, and p21; It is thought that it creates these anti-cancer effects by regulating Treg cells, which are anti-inflammatory cells. Many probiotics are sold as dietary supplements that do not require United States Food and Drug Administration (FDA) approval before marketing. Kefir is not FDA approved as a cancer drug or cancer preventive drug. It should not be forgotten that treatment or supportive treatment is not included in current oncology guidelines.
References
Azizi NF, Kumar MR, Yeap SK, Abdullah JO, Khalid M, Omar AR, Osman MA, Mortadza SAS, Alitheen NB. Kefir and Its Biological Activities. Foods. 2021 May 27;10(6):1210. doi: 10.3390/foods10061210. PMID: 34071977; PMCID: PMC8226494.
Yegin Z, Sudagidan M. A medical and molecular approach to kefir as a therapeutic agent of human microbiota. Int J Vitam Nutr Res. 2022 Sep 7. doi: 10.1024/0300-9831/a000765. Epub ahead of print. PMID: 36068959.
Zhao J, Wang Y, Wang J, et al. Lactobacillus kefiranofaciens ZW18 from Kefir enhances the anti-tumor effect of anti-programmed cell death 1 (PD-1) immunotherapy by modulating the gut microbiota. Food Funct. 2022;13(19):10023-10033. Published 2022 Oct 3. doi:10.1039/d2fo01747d
Prados-Bo A, Rabassa M, Bosch M, Casino G. Online information in Spanish on probiotics, yoghurt, kefir, kombucha, fibre and prebiotics: an analysis of the quality of information and the certainty of the evidence supporting health claims. BMJ Open. 2022 Aug 3;12(8):e063316. doi: 10.1136/bmjopen-2022-063316. PMID: 35922106; PMCID: PMC9352994.
Zeng X, Jia H, Shi Y, et al. Lactobacillus kefiranofaciens JKSP109 and Saccharomyces cerevisiae JKSP39 isolated from Tibetan kefir grain co-alleviated AOM/DSS induced inflammation and colorectal carcinogenesis. Food Funct. 2022;13(13):6947-6961. Published 2022 Jul 4. doi:10.1039/d1fo02939h
Guiomar de Almeida Brasiel P, Cristina Potente Dutra Luquetti S, Dutra Medeiros J, et al. Kefir modulates gut microbiota and reduces DMH-associated colorectal cancer via regulation of intestinal inflammation in adulthood offsprings programmed by neonatal overfeeding. Food Res Int. 2022;152:110708. doi:10.1016/j.foodres.2021.110708
Qi, G., Tang, B., Zhou, L., Jikihara, H., Kiwata, A., Sakamoto, Y., … Shimamoto, F. (2015). Effects of high fat diet on 1,2 dimethylhydrazine induced aberrant crypt foci and colorectal tumours in rats. Biomedical Reports, 3(3), 289–294.
Wouw, M. Van De, Walsh, A. M., Crispie, F., Leuven, L. Van, Lyte, J. M., Boehme, M., … Cryan, J. F. (2020). Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse. Microbiome, 8, 67.
Choudhari, S. Korde, et al. "Nitric oxide and cancer: A review, World." J. Surg. Oncol. 11 (2013): 1-11.
Patel K, Patel DK. The Potential Therapeutic Properties of Prunetin against Human Health Complications: A Review of Medicinal Importance and Pharmacological Activities. Drug Metab Bioanal Lett. 2022;15(3):166-177. doi:10.2174/2949681015666220912104743
Zeng X, Jia H, Zhang X, et al. Supplementation of kefir ameliorates azoxymethane/dextran sulfate sodium induced colorectal cancer by modulating the gut microbiota. Food Funct. 2021;12(22):11641-11655. Published 2021 Nov 15. doi:10.1039/d1fo01729b
Smoak P, Harman N, Flores V, et al. Kefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise Program. Med Sci Sports Exerc. 2021;53(10):2045-2053. doi:10.1249/MSS.0000000000002690
Larosa CP, Balthazar CF, Guimarães JT, et al. Can sucrose-substitutes increase the antagonistic activity against foodborne pathogens, and improve the technological and functional properties of sheep milk kefir?. Food Chem. 2021;351:129290. doi:10.1016/j.foodchem.2021.129290
Kumar MR, Yeap SK, Lee HC, et al. Selected Kefir Water from Malaysia Attenuates Hydrogen Peroxide-Induced Oxidative Stress by Upregulating Endogenous Antioxidant Levels in SH-SY5Y Neuroblastoma Cells. Antioxidants (Basel). 2021;10(6):940. Published 2021 Jun 10. doi:10.3390/antiox10060940
Sabokbar N., Khodaiyan F. Total Phenolic Content and Antioxidant Activities of Pomegranate Juice and Whey Based Novel Beverage Fermented by Kefir Grains. J. Food Sci. Technol. 2016;53:739–747. doi: 10.1007/s13197-015-2029-
Garrote G.L., Abraham A.G., De Antoni G.L. Inhibitory Power of Kefir: The Role of Organic Acids. J. Food Prot. 2000;63:364–369. doi: 10.4315/0362-028X-
Fatahi A, Soleimani N, Afrough P. Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment. Int J Food Sci. 2021;2021:8180742. Published 2021 Jan 12. doi:10.1155/2021/8180742
Plessas S, Kiousi DE, Rathosi M, et al. Isolation of a Lactobacillus paracasei Strain with Probiotic Attributes from Kefir Grains. Biomedicines. 2020;8(12):594. Published 2020 Dec 11. doi:10.3390/biomedicines8120594
Vitetta L, Vitetta G, Hall S. Immunological tolerance and function: associations between intestinal bacteria, probiotics, prebiotics, and phages. Front Immunol 2018;9:2240. 10.3389/fimmu.2018.02240
Gamallat Y, Meyiah A, Kuugbee ED, et al.. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model. Biomed Pharmacother 2016;83:536–41. 10.1016/j.biopha.2016.07.001
Serban DE. Gastrointestinal cancers: influence of gut microbiota, probiotics and prebiotics. Cancer Lett 2014;345:258–70. 10.1016/j.canlet.2013.08.013
Fotiadis C-I, Stoidis C-N, Spyropoulos B-G, et al.. Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer. World J Gastroenterol 2008
Dikeocha IJ, Al-Kabsi AM, Hussin S, Alshawsh MA. Role of probiotics in patients with colorectal cancer: a systematic review protocol of randomised controlled trial studies. BMJ Open. 2020;10(8):e038128. Published 2020 Aug 7. doi:10.1136/bmjopen-2020-038128
Stewart LK, Smoak P, Hydock DS, et al. Milk and kefir maintain aspects of health during doxorubicin treatment in rats. J Dairy Sci. 2019;102(3):1910-1917. doi:10.3168/jds.2018-15576
