Likopen (Solanum Lycopersicum)
Özet
Likopen parlak kırmızı bir karotenoiddir, domateste ve domatesten üretilen gıdalarda bol miktarda bulunur. İnsan vücudunda üretilmez. Likopenin kanser gelişimi, bazı kanser türlerinin oluşumu ve hastalık yanıtı üzerindeki etkilerini inceleyen, özellikle hayvan modelleri olmak üzere pek çok çalışma bulunmaktadır. Antikanserojenik etkisinin antioksidan özelliklerinden kaynaklandığı düşünülmektedir. Prostat kanseri üzerindeki etkinliği birçok insan ve hayvan çalışmasında gösterilmiştir. Diğer kanser türlerinde etkinliğinin belirlenmesi için faz 3 randomize çalışmalara ihtiyaç vardır. Takviye olarak kullanımını önermek için daha fazla insan güvenliği ve etkililik çalışmasına ihtiyaç vardır. Nörolojik, kardiyovasküler hastalıklar ve nöropatik ağrı üzerindeki etkinliğini belirlemek için hayvan çalışmaları bulunmaktadır. Günlük öğünlerde doğal gıdalar kullanıldığında ciddi bir yan etki görülmemektedir. Onkolojik açıdan düzenli kullanımını önerecek yeterli veri yoktur.
Lycopene is a bright red carotenoid and is abundant in tomatoes and foods produced from tomatoes. It is not produced in the human body. There are many studies, especially animal models, examining the effects of lycopene on cancer development, the formation of some types of cancer, and disease response. It is thought that its anticarcinogenic effect is due to its antioxidant properties. Its effectiveness on prostate cancer has been demonstrated in many human and animal studies. Phase 3 randomized studies are needed to determine its effectiveness in other types of cancer. More human safety and effectiveness studies are needed to recommend its use as a supplement. There are animal studies to determine its effectiveness on neurological, cardiovascular diseases and neuropathic pain. There are no serious side effects shown when using natural foods in daily meals. There is not enough data to recommend its use in terms of oncology.
Referanslar
Khan, U.M.; Sevindik, M.; Zarrabi, A.; Nami, M.; Ozdemir, B.; Kaplan, D.N.; Selamoglu, Z.; Hasan, M.; Kumar, M.; Alshehri, M.M.; et al. Lycopene: Food Sources, Biological Activities, and Human Health Benefits. Oxid. Med. Cell. Longev. 2021, 2021, 2713511.
Zechmeister, L.; Went, F.W.;Lerosen , Pauling, L. Prolycopene, a Naturally Occuring Stereoisomer of Lycopene. Proc. Natl. Acad. Sci. USA 1941, 27, 468–474.
Rao, A.V.; Waseem, Z.; Agarwal, S. Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene. Food Res. Int. 1998, 31, 737–741.
Unlu, N.Z.; Bohn, T.; Francis, D.M.; Nagaraja, H.N.; Clinton, S.K.; Schwartz, S.J. Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. Br. J. Nutr. 2007, 98, 140–146.
Heber D, Lu QY. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood) 2002;227(10):920- 3.
Straub O. Key to carotenoids. Lists of natural carotenoids. In: Pfander H, editor. Birkhauser Verlag: Basel (1976).
Setiawan B, Sulaeman A, Giraud DW, Driskell JA. Carotenoid Content of Selected Indonesian Fruits. Journal of Food Composition and Analysis 2001; 14: 169-176.
Agarwal S, Rao AV. Tomato lycopene and its role in human health and chronic diseases. CMAJ 2000;163(6):739-44.
Stahl W and Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 1992; 122: 2161-2166.
Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 2008; 10: 475-51
Pizarro L, and Stange C. Light-dependent regulation of carotenoid biosynthesis in plants. Cien Inv Agr 2009; 36: 143-162.
Krinsky NI. Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 1992; 200: 248-254.
Park YO, Hwang ES, Moon TW. The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. Biofactors 2005; 23: 129-139.
Nakanishi, R.; Shimizu, T.; Kumagai, K.; Takai, A.; Marusawa, H. Genetic Pathogenesis of Inflammation-Associated Cancers in Digestive Organs. Pathogens 2021, 10, 453.
Kucuk, O.; Sarkar, F.H.; Djuric, Z.; Sakr, W.; Pollak, M.N.; Khachik, F.; Banerjee, M.; Bertram, J.S.;Wood, D.P. Effects of lycopene supplementation in patients with localized prostate cancer. Exp. Biol. Med. 2002, 227, 881–885.
Ansari, M.S.; Gupta, N.P. Lycopene: A novel drug therapy in hormone refractory metastatic prostate cancer. Urol. Oncol. 2004, 22, 415–420. Ansari, M.S.; Gupta, N.P. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2003, 92, 375–378; discussion 378.
Tang L, Jin T, Zeng X, Wang JS. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. Journal of Nutrition 2005; 135: 287-290.
Tang, Y.; Parmakhtiar, B.; Simoneau, A.R.; Xie, J.; Fruehauf, J.; Lilly, M.; Zi, X. Lycopene enhances docetaxel’s effect in castrationresistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia 2011, 13, 108–119.
Bowen, P.; Chen, L.; Stacewicz-Sapuntzakis, M.; Duncan, C.; Sharifi, R.; Ghosh, L.; Kim, H.-S.; Christov-Tzelkov, K.; van Breemen, R. Tomato sauce supplementation and prostate cancer: Lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp. Biol. Med. 2002, 227, 886–893 .
Palan, P.R.; Mikhail, M.S.; Goldberg, G.L.; Basu, J.; Runowicz, C.D.; Romney, S.L. Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer. Clin. Cancer Res. 1996, 2, 181–185.
Sahin, K.; Cross, B.; Sahin, N.; Ciccone, K.; Suleiman, S.; Osunkoya, A.O.; Master, V.; Harris,W.; Carthon, B.; Mohammad, R.; et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch. Biochem. Biophys. 2015, 572, 36–39.
Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K. Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Res 1995;15(4):1173-8.
Sahin, K.; Tuzcu, M.; Sahin, N.; Akdemir, F.; Ozercan, I.; Bayraktar, S.; Kucuk, O. Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats. Nutr. Cancer 2011, 63, 1279–1286.
Sengngam, K.; Hoc, T.H.; Hang, D.V.; Tran Ngoan, L. TransLycopene and _-Cryptoxanthin Intake and Stomach Cancer in Vietnamese Men: A Pilot Case-Control Study. Asian Pac. J. Cancer Prev. 2022, 23, 861–865 .
Tang, F.-Y.; Pai, M.-H.; Kuo, Y.-H.;Wang, X.-D. Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. Mol. Nutr. Food Res. 2012, 56, 1520–1531.
Nahum A, Zeller L, Danilenko M. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Cancer 2006; 45: 275-282.
Vrieling, A.; Voskuil, D.W.; Bonfrer, J.M.; Korse, C.M.; van Doorn, J.; Cats, A.; Depla, A.C.; Timmer, R.; Witteman, B.J.; van Leeuwen, F.E.; et al. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am. J. Clin. Nutr. 2007, 86, 1456–1462.
Moroni, M.; Pirovano, M.; Brugnatelli, S.; Zucca, M.; Morreale, M.; Rizzo, V.; Ferrari, A.; Tinelli, C.; De Silvestri, A.; Meregalli, M.; et al. Lycopene minimizes skin toxicity and oxidative stress in patients treated with panitumumab-containing therapy for metastatic colorectal cancer. J. Funct. Foods 2021, 83, 104533.
Nkondjock, A.; Ghadirian, P.; Johnson, K.C.; Krewski, D. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J. Nutr. 2005, 135, 592–597.
Watanabe, S.; Kitade, Y.; Masaki, T.; Nishioka, M.; Satoh, K.; Nishino, H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. Nutr. Cancer 2001, 39, 96–101.
Aizawa, K.; Liu, C.; Tang, S.; Veeramachaneni, S.; Hu, K.-Q.; Smith, D.E.;Wang, X.-D. Tobacco carcinogen induces both lung cancer and nonalcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. Int. J. Cancer 2016, 139, 1171–1181.
Mayne, S.T.; Cartmel, B.; Lin, H.; Zheng, T.; Goodwin,W.J.J. Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers. J. Am. Coll. Nutr. 2004, 23, 34–42.
Voskuil, D.W.; Vrieling, A.; Korse, C.M.; Beijnen, J.H.; Bonfrer, J.M.G.; van Doorn, J.; Kaas, R.; Oldenburg, H.S.A.; Russell, N.S.; Rutgers, E.J.T.; et al. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Nutr. Cancer 2008, 60, 342–353.
Moody, L.; Crowder, S.L.; Fruge, A.D.; Locher, J.L.; DemarkWahnefried, W.; Rogers, L.Q.; Delk-Licata, A.; Carroll, W.R.; Spencer, S.A.; Black, M.; et al. Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes. Clin. Epigenetics 2020, 12, 138.
Helzlsouer, K.J.; Comstock, G.W.; Morris, J.S. Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res. 1989, 49, 6144–6148.
Chen, P.; Xu, S.; Qu, J. Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a through the mTORC2/AKT Signaling Pathway. J. Cell. Biochem. 2018, 119, 366–377.
Radhakrishnan, V.K.; Ravikumar, V.; Shivashangari, K.; Sattu, K.; Devaki, T. Chemopreventive Role of Lycopene and D-arginine in Benzo(a) Pyrene Induced Lung Cancer with Reference to Lipid Peroxidation, Antioxidant and Tumor Marker Enzymes. Int. J. Cancer Res. 2006, 2, 224–233.
Jiang, X.; Wu, H.; Zhao, W.; Ding, X.; You, Q.; Zhu, F.; Qian, M.; Yu, P. Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. Cancer Cell Int. 2019, 19, 68.
Gottlieb TM and Jackson SP. The DNAdependent protein kinase: requirement for DNAends and association with Ku antigen. Cell 1993; 72: 131–142.
Jackson SP, Jeggo PA. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci 1995; 20: 412-415.
Song JY, Lim JW, Kim H et al. Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. J Biol Chem 2003; 278: 36676-36687.
Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, Menon VP. Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro. Biochim Biophys Acta 2007; 1770: 659-665.
Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2003; 1:226–231.
Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME. Lycopene differentially induces quiescence and apoptosis in androgenresponsive and –independent prostate cancer cell lines. Clinical Nutrition 2007; 26:252- 263.
Nahum A, Zeller L, Danilenko M. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Cancer 2006; 45: 275-282.
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Suppression by carotenoids of microcystin-induced morphological changes in Mouse hepatocytes. Lipids 1995; 30: 10291034.
Lian F, Smith DE, Ernst H, Russell RM, Wang XD. Apo-10′- lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 2007; 28: 1567–1574.
Salman H, Bergman M, Djaldetti M, Bessler H (2007) Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother (2007); 61: 366-369.
Chiang HS, Wu WB, Fang JY. Lycopene inhibits PDGFBB- induced signalling and migration in human dermal fibroblasts through interaction with PDF-BB. Life Sci 2007; 81: 1509–1517.
Hwang ES, Lee HJ. Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK-Hep1 human hepatoma cells. Exp Biol Med (Maywood) 2006; 231: 322- 327.
Colditz GA, Branch LG, Lipnick RJ, Willett WC, Rosner B, Posner BM, et al. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr 1985;41(1):32-6.
Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K. Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Res 1995;15(4):1173-8.
Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14(5):1074-81.
Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995;87(23):1767-76.
Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 1999;91(4):317-31.
Tsugane S, Tsuda M, Gey F, Watanabe S. Cross-sectional study with multiple measurements of biological markers for assessing stomach cancer risks at the population level. Environ Health Perspect 1992;98:207-10.
Gupta S, Dasmahapatra AK. Lycopene destabilizes preformed Aβ fibrils: Mechanistic insights from all-atom molecular dynamics simulation. Comput Biol Chem. 2023 Aug;105:107903. doi: 10.1016/j.compbiolchem.2023.107903. Epub 2023 Jun 10. PMID: 37320982.
Kapoor B, Gulati M, Rani P, Kochhar RS, Atanasov AG, Gupta R, Sharma D, Kapoor D. Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease. Biofactors. 2023 Mar;49(2):208-227. doi: 10.1002/biof.1910. Epub 2022 Nov 1. PMID: 36318372.
Datta S, Jamwal S, Deshmukh R, Kumar P. Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation. Eur J Pharmacol. 2016 Jan 15;771:229-35. doi: 10.1016/j.ejphar.2015.12.032. Epub 2015 Dec 19. PMID: 26712377.
Zhang FF, Morioka N, Kitamura T, Fujii S, Miyauchi K, Nakamura Y, Hisaoka-Nakashima K, Nakata Y. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression. Life Sci. 2016 Jun 15;155:116-22. doi: 10.1016/j.lfs.2016.05.021. Epub 2016 May 16. PMID: 27197028.
Tanaka A, Miyauchi T, Kitamura S, Iwata H, Hata H, Ujiie H. Carotenoderma due to lycopenemia: A case report and evaluation of lycopene deposition in the skin. J Dermatol. 2022 Dec;49(12):1320-1324. doi: 10.1111/1346-8138.16537. Epub 2022 Aug 8. PMID: 35938228.
Kong L, Song C, Ye L, Xu J, Guo D, Shi Q. The effect of lycopene on cytochrome P450 isoenzymes and P-glycoprotein by using human liver microsomes and Caco-2 cell monolayer model. Int J Food Sci Nutr. 2018 Nov;69(7):835-841. doi: 10.1080/09637486.2017.1420756. Epub 2018 Jan 11. PMID: 29322841.
Fuentes E, Trostchansky A, Reguengo LM, Junior MRM, Palomo I. Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace.Curr Drug Targets. 2021;22(15):1716-1724. doi: 10.2174/1389450122999210128180456. PMID: 33511954.
Zechmeister, L.; Went, F.W.;Lerosen , Pauling, L. Prolycopene, a Naturally Occuring Stereoisomer of Lycopene. Proc. Natl. Acad. Sci. USA 1941, 27, 468–474.
Rao, A.V.; Waseem, Z.; Agarwal, S. Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene. Food Res. Int. 1998, 31, 737–741.
Unlu, N.Z.; Bohn, T.; Francis, D.M.; Nagaraja, H.N.; Clinton, S.K.; Schwartz, S.J. Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. Br. J. Nutr. 2007, 98, 140–146.
Heber D, Lu QY. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood) 2002;227(10):920- 3.
Straub O. Key to carotenoids. Lists of natural carotenoids. In: Pfander H, editor. Birkhauser Verlag: Basel (1976).
Setiawan B, Sulaeman A, Giraud DW, Driskell JA. Carotenoid Content of Selected Indonesian Fruits. Journal of Food Composition and Analysis 2001; 14: 169-176.
Agarwal S, Rao AV. Tomato lycopene and its role in human health and chronic diseases. CMAJ 2000;163(6):739-44.
Stahl W and Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 1992; 122: 2161-2166.
Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 2008; 10: 475-51
Pizarro L, and Stange C. Light-dependent regulation of carotenoid biosynthesis in plants. Cien Inv Agr 2009; 36: 143-162.
Krinsky NI. Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 1992; 200: 248-254.
Park YO, Hwang ES, Moon TW. The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. Biofactors 2005; 23: 129-139.
Nakanishi, R.; Shimizu, T.; Kumagai, K.; Takai, A.; Marusawa, H. Genetic Pathogenesis of Inflammation-Associated Cancers in Digestive Organs. Pathogens 2021, 10, 453.
Kucuk, O.; Sarkar, F.H.; Djuric, Z.; Sakr, W.; Pollak, M.N.; Khachik, F.; Banerjee, M.; Bertram, J.S.;Wood, D.P. Effects of lycopene supplementation in patients with localized prostate cancer. Exp. Biol. Med. 2002, 227, 881–885.
Ansari, M.S.; Gupta, N.P. Lycopene: A novel drug therapy in hormone refractory metastatic prostate cancer. Urol. Oncol. 2004, 22, 415–420. Ansari, M.S.; Gupta, N.P. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2003, 92, 375–378; discussion 378.
Tang L, Jin T, Zeng X, Wang JS. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. Journal of Nutrition 2005; 135: 287-290.
Tang, Y.; Parmakhtiar, B.; Simoneau, A.R.; Xie, J.; Fruehauf, J.; Lilly, M.; Zi, X. Lycopene enhances docetaxel’s effect in castrationresistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia 2011, 13, 108–119.
Bowen, P.; Chen, L.; Stacewicz-Sapuntzakis, M.; Duncan, C.; Sharifi, R.; Ghosh, L.; Kim, H.-S.; Christov-Tzelkov, K.; van Breemen, R. Tomato sauce supplementation and prostate cancer: Lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp. Biol. Med. 2002, 227, 886–893 .
Palan, P.R.; Mikhail, M.S.; Goldberg, G.L.; Basu, J.; Runowicz, C.D.; Romney, S.L. Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer. Clin. Cancer Res. 1996, 2, 181–185.
Sahin, K.; Cross, B.; Sahin, N.; Ciccone, K.; Suleiman, S.; Osunkoya, A.O.; Master, V.; Harris,W.; Carthon, B.; Mohammad, R.; et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch. Biochem. Biophys. 2015, 572, 36–39.
Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K. Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Res 1995;15(4):1173-8.
Sahin, K.; Tuzcu, M.; Sahin, N.; Akdemir, F.; Ozercan, I.; Bayraktar, S.; Kucuk, O. Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats. Nutr. Cancer 2011, 63, 1279–1286.
Sengngam, K.; Hoc, T.H.; Hang, D.V.; Tran Ngoan, L. TransLycopene and _-Cryptoxanthin Intake and Stomach Cancer in Vietnamese Men: A Pilot Case-Control Study. Asian Pac. J. Cancer Prev. 2022, 23, 861–865 .
Tang, F.-Y.; Pai, M.-H.; Kuo, Y.-H.;Wang, X.-D. Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. Mol. Nutr. Food Res. 2012, 56, 1520–1531.
Nahum A, Zeller L, Danilenko M. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Cancer 2006; 45: 275-282.
Vrieling, A.; Voskuil, D.W.; Bonfrer, J.M.; Korse, C.M.; van Doorn, J.; Cats, A.; Depla, A.C.; Timmer, R.; Witteman, B.J.; van Leeuwen, F.E.; et al. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am. J. Clin. Nutr. 2007, 86, 1456–1462.
Moroni, M.; Pirovano, M.; Brugnatelli, S.; Zucca, M.; Morreale, M.; Rizzo, V.; Ferrari, A.; Tinelli, C.; De Silvestri, A.; Meregalli, M.; et al. Lycopene minimizes skin toxicity and oxidative stress in patients treated with panitumumab-containing therapy for metastatic colorectal cancer. J. Funct. Foods 2021, 83, 104533.
Nkondjock, A.; Ghadirian, P.; Johnson, K.C.; Krewski, D. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J. Nutr. 2005, 135, 592–597.
Watanabe, S.; Kitade, Y.; Masaki, T.; Nishioka, M.; Satoh, K.; Nishino, H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. Nutr. Cancer 2001, 39, 96–101.
Aizawa, K.; Liu, C.; Tang, S.; Veeramachaneni, S.; Hu, K.-Q.; Smith, D.E.;Wang, X.-D. Tobacco carcinogen induces both lung cancer and nonalcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. Int. J. Cancer 2016, 139, 1171–1181.
Mayne, S.T.; Cartmel, B.; Lin, H.; Zheng, T.; Goodwin,W.J.J. Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers. J. Am. Coll. Nutr. 2004, 23, 34–42.
Voskuil, D.W.; Vrieling, A.; Korse, C.M.; Beijnen, J.H.; Bonfrer, J.M.G.; van Doorn, J.; Kaas, R.; Oldenburg, H.S.A.; Russell, N.S.; Rutgers, E.J.T.; et al. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Nutr. Cancer 2008, 60, 342–353.
Moody, L.; Crowder, S.L.; Fruge, A.D.; Locher, J.L.; DemarkWahnefried, W.; Rogers, L.Q.; Delk-Licata, A.; Carroll, W.R.; Spencer, S.A.; Black, M.; et al. Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes. Clin. Epigenetics 2020, 12, 138.
Helzlsouer, K.J.; Comstock, G.W.; Morris, J.S. Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res. 1989, 49, 6144–6148.
Chen, P.; Xu, S.; Qu, J. Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a through the mTORC2/AKT Signaling Pathway. J. Cell. Biochem. 2018, 119, 366–377.
Radhakrishnan, V.K.; Ravikumar, V.; Shivashangari, K.; Sattu, K.; Devaki, T. Chemopreventive Role of Lycopene and D-arginine in Benzo(a) Pyrene Induced Lung Cancer with Reference to Lipid Peroxidation, Antioxidant and Tumor Marker Enzymes. Int. J. Cancer Res. 2006, 2, 224–233.
Jiang, X.; Wu, H.; Zhao, W.; Ding, X.; You, Q.; Zhu, F.; Qian, M.; Yu, P. Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. Cancer Cell Int. 2019, 19, 68.
Gottlieb TM and Jackson SP. The DNAdependent protein kinase: requirement for DNAends and association with Ku antigen. Cell 1993; 72: 131–142.
Jackson SP, Jeggo PA. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci 1995; 20: 412-415.
Song JY, Lim JW, Kim H et al. Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. J Biol Chem 2003; 278: 36676-36687.
Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, Menon VP. Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro. Biochim Biophys Acta 2007; 1770: 659-665.
Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2003; 1:226–231.
Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME. Lycopene differentially induces quiescence and apoptosis in androgenresponsive and –independent prostate cancer cell lines. Clinical Nutrition 2007; 26:252- 263.
Nahum A, Zeller L, Danilenko M. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Cancer 2006; 45: 275-282.
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Suppression by carotenoids of microcystin-induced morphological changes in Mouse hepatocytes. Lipids 1995; 30: 10291034.
Lian F, Smith DE, Ernst H, Russell RM, Wang XD. Apo-10′- lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 2007; 28: 1567–1574.
Salman H, Bergman M, Djaldetti M, Bessler H (2007) Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother (2007); 61: 366-369.
Chiang HS, Wu WB, Fang JY. Lycopene inhibits PDGFBB- induced signalling and migration in human dermal fibroblasts through interaction with PDF-BB. Life Sci 2007; 81: 1509–1517.
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Sayfalar
259-268
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Özkan O. Likopen (Solanum Lycopersicum). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 259-68. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13926
