Keçiboynuzu (Ceratonia Siliqua)
Özet
Bilimsel olarak Ceratonia siliqua L. olarak bilinen keçiboynuzu, Akdeniz bölgesinden gelen, önemli değere sahip uzun ömürlü bir bitkidir. Keçiboynuzu bitkisi polifenoller, falvonoidler ve tanninler gibi önemli miktarda biyoaktif bileşik içermektedir ve geleneksel tıpta pek çok farklı hastalığın tedavisinde kullanılmaktadır. Güncel verilerle keçboynuzunun aktif bileşenlerinin hücre çoğalmasını engelleyici, apoptozu tetikleyici ve anti-oksidan etkileri görülse de kanser hastalığının tedavisindeki rolü hakkında net bir fikir birliği bulunmamaktadır. Bu bölümde keçiboynuzu bitkisinin aktif bileşenlerinin kanser tedavisi ve ilaç etkileşimleri üzerine olan olumlu ve olumsuz sonuçları kanıta dayalı tıbbi bilgiler eşliğinde değerlendirilerek özetlenmeye çalışılmıştır.
Carob, scientifically known as Ceratonia siliqua L., is an perennial plant of significant value that originates from the Mediterranean region. The carob plant contains a significant amount of bioactive compounds including polyphenols, flavonoids, and tannins, and have been used in traditional medicine for the treatment of many different diseases. Based on the most recent research, despite the active compounds of carob have the ability to inhibit proliferation of cells, trigger apoptosis, and function as antioxidants, there is no definitive evidence regarding its efficacy in treatment cancer. In this section, the positive and negative results of the active components of the carob plant on cancer treatment and drug interactions have been evaluated and summarized in the light of evidence-based medical information.
Referanslar
Battle, Ignacio, and Joan Tous. Carob tree Ceratonia siliqua L. 1997.
Goulas V, Stylos E, Chatziathanasiadou M V., Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. Vol. 17, International Journal of Molecular Sciences. MDPI AG; 2016.
Kotrotsios N, Christaki E, Bonos E, Florou-Paneri P. Dietary carob pods on growth performance and meat quality of fattening pigs. Asian-Australas J Anim Sci. 2012;25(6):880–5.
Faramarzi A, Aghaz F, Golestan Jahromi M, Bakhtiari M, Khazaei M. Does supplementation of sperm freezing/thawing media with Ceratonia siliqua improve detrimental effect of cryopreservation on sperm parameters and chromatin quality in normozoospermic specimens? Cell Tissue Bank. 2019.
] Ferguson, L.R., 2005. Does a diet rich in dietary fibre really reduce the risk of colon cancer? Digestive and Liver Disease 37: 139-141.
Zunft, F.J.H., Lüder, W.,Harde, B.,Haber, B., Graubaum, H.J., Gruenwald, J., 2001. Carob pulp preparation for treatment of hypercholesterolemia. Advances in Therapy 18(5): 230-236.
Zunft, F.J.H., Lüder, W., Harde, B., Graubaum, J.H., Koebnick, C., Grünwald, J., 2003. Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. European Journal of Nutrition 42(5): 235-242.
Rahmoun, N. M., Ziane, H., & Boucherit-Otmani, Z. (2014). Antibacterial and antifungal screening of four medicinal plants. Journal of Coastal Life Medicine, 2(12), 975–979.
Aissani, N., Coroneo, V., Fattouch, S., & Caboni, P. (2012). Inhibitory effect of carob (Ceratonia siliqua) leaves methanolic extract on Listeria monocytogenes. Journal of Agricultural and Food Chemistry, 60(40), 9954–9958.
Meziani, S., Oomah, B. D., Zaidi, F., Simon-Levert, A., Bertrand, C., & Zaidi-Yahiaoui, R. (2015). Antibacterial activity of carob (Ceratonia siliqua L.) extracts against phytopathogenic bacteria Pectobacterium atrosepticum. Microbial Pathogenesis, 78, 95– 102.
Souli, A., Sebai, H., Chehimi, L., Rtibi, K., Tounsi, H., Baubaker, S., Sakly, M., El-Benna, J., Amri, M., 2013. Hepatoprotective effect of carob against acute ethanol- induced oxidative stress in rat. Toxicology and Industrial Health doi:10.1177/0748233713475506 .
Ahmed, M.M., 2010. Biochemical studies on nephroprotective effect of carob (Ceratonia siliqua L.) growing in Egypt. Nature and Science 8(3): 41- 47.
Roseiro, L. B., Duarte, L. C., Oliveira, D. L., Roque, R., Bernardo-Gil, M. G., Martins, A. I., Sepúlveda, C., Almeida, J., Meireles, M., Gírio, F. M., & Rauter, A. P. (2013). Supercritical, ultrasound and conventional extracts from carob (Ceratonia siliqua L.) biomass: Effect on the phenolic profile and antiproliferative activity. Industrial Crops and Products, 47, 132– 138.
Dhaouadi, K., Belkhir, M., Akinocho, I., Raboudi, F., Pamies, D., Barrajón, E., Estevan, C., & Fattouch, S. (2014). Sucrose supplementation during traditional carob syrup processing affected its chemical characteristics and biological activities. LWT-Food Science and Technology, 57(1), 1– 8.
Abu Hafsa, S. H., Ibrahim, S. A., & Hassan, A. A. (2017). Carob pods (Ceratonia siliqua L.) improve growth performance, antioxidant sta-tus and caecal characteristics in growing rabbits. Journal of Animal Physiology and Animal Nutrition, 101(6), 1307– 1315.
Kim, J.I., Kim, J.C., Kang, M.J., Lee, M.S., Kim, J.J., Cha, I.J., 2005. Effects of Pinitol isolated from soybeans on glycemic control and cardiovascular risk factors in Korean patients with type 2 diabetes mellitus: a randomized controlled study. European Journal of Clinical Nutrition 59: 456-458.
Gruendel, S., Otto, B., Garcia, A. L., Wagner, K., Mueller, C., Weickert, M. O., Heldwein, W., & Koebnick, C. (2007). Carob pulp preparation 3652 |IKRAMetal.rich in insoluble dietary fibre and polyphenols increases plasma glucose and serum insulin responses in combination with a glucose load in humans. British Journal of Nutrition, 98(1), 101– 105.
Sassi A, Bouhlel I, Mustapha N, et al. Assessment in vitro of the genotoxicity, antigenotoxicity and antioxidant of Ceratonia siliqua L. extracts in murine leukaemia cells L1210 by comet assay. Regul Toxicol Pharmacol 2016; 77: 117- 24.
Sarmiento-Salinas, F.L.; Delgado-Magallón, A.; Montes-Alvarado, J.B.; Ramírez-Ramírez, D.; Flores-Alonso, J.C.; Cortés-Hernández, P.; Reyes-Leyva, J.; Herrera-Camacho, I.; Anaya-Ruiz, M.; Pelayo, R.; et al. Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment. Front. Oncol. 2019, 9, 480.
Hecht, F.; Pessoa, C.F.; Gentile, L.B.; Rosenthal, D.; Carvalho, D.P.; Fortunato, R.S. The Role of Oxidative Stress on Breast Cancer Development and Therapy. Tumor Biol. 2016, 37, 4281–4291. .
Lin, Tien-Huang, et al. ‘D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways.’ International journal of molecular sciences 14.5 (2013): 9790-9802.
Custódio, Luísa, et al. ‘Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua).’ Pharmaceutical biology 47.8 (2009): 721-728.
Klenow, S., et al. ‘Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells.’ Food and Chemical Toxicology 46.4 (2008): 1389-1397.
Khazaei AH, Faramarzi A, Khazaei M. Therapeutic and functional application of ceratonia siliqua: tradition remedies and new research finding. Journal of Knowledge & Health in Basic Medical Sciences 2022;17(3):18-25. doi.org/10.22100/jkh.v17i3.2862.
Gurel, Furkan, Husamettin Ekici, and Begum Yurdakok Dikmen. ‘Cytotoxic and antitumoral effect of Ceratonia siliquracta L.(carob) extract.’ Journal of Applied Biological Sciences 15.2 (2021): 225-234.
Corsi, Lorenzo, et al. ‘Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line.’ Fitoterapia 73.7-8 (2002): 674-684.
Gregoriou, Gregoria, et al. ‘Anti-cancer activity and phenolic content of extracts derived from Cypriot carob (Ceratonia siliqua L.) pods using different solvents.’ Molecules 26.16 (2021): 5017.
Custódio, Luísa, et al. ‘In vitro cytotoxic effects and apoptosis induction by a methanol leaf extract of carob tree (Ceratonia siliqua L.).’ Journal of Medicinal Plant Research 5.10 (2011): 1987-1996.
Custódio, Luísa, et al. ‘Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts.’ Plant foods for human nutrition 66 (2011): 78-84.
Ohno, Yasushi, et al. ‘Induction of apoptosis by gallic acid in lung cancer cells.’ Anti-cancer drugs 10.9 (1999): 845-852.
Chiu, Chun‐Tang, et al. ‘Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis, and autophagy.’ Journal of food science 80.3 (2015): H649-H658.
Satoh, Motohiko, et al. ‘EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy.’ Cancer cell international 13.1 (2013): 1-8.
Elbouzidi, Amine, et al. ‘Exploring the Multi-Faceted Potential of Carob (Ceratonia siliqua var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial Activity, Cytotoxicity against Breast Cancer Cell Lines, and Genotoxicity.’ Pharmaceuticals 16.6 (2023): 840.
Pouresmaeil, Vahid, et al. ‘The anti-breast cancer effects of green-synthesized zinc oxide nanoparticles using carob extracts.’ Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 21.3 (2021): 316-326.
Stupans, Ieva, et al. ‘Inhibition of CYP3A‐mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid.’ Journal of pharmacy and pharmacology 54.2 (2002): 269-275.
Goulas V, Stylos E, Chatziathanasiadou M V., Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. Vol. 17, International Journal of Molecular Sciences. MDPI AG; 2016.
Kotrotsios N, Christaki E, Bonos E, Florou-Paneri P. Dietary carob pods on growth performance and meat quality of fattening pigs. Asian-Australas J Anim Sci. 2012;25(6):880–5.
Faramarzi A, Aghaz F, Golestan Jahromi M, Bakhtiari M, Khazaei M. Does supplementation of sperm freezing/thawing media with Ceratonia siliqua improve detrimental effect of cryopreservation on sperm parameters and chromatin quality in normozoospermic specimens? Cell Tissue Bank. 2019.
] Ferguson, L.R., 2005. Does a diet rich in dietary fibre really reduce the risk of colon cancer? Digestive and Liver Disease 37: 139-141.
Zunft, F.J.H., Lüder, W.,Harde, B.,Haber, B., Graubaum, H.J., Gruenwald, J., 2001. Carob pulp preparation for treatment of hypercholesterolemia. Advances in Therapy 18(5): 230-236.
Zunft, F.J.H., Lüder, W., Harde, B., Graubaum, J.H., Koebnick, C., Grünwald, J., 2003. Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. European Journal of Nutrition 42(5): 235-242.
Rahmoun, N. M., Ziane, H., & Boucherit-Otmani, Z. (2014). Antibacterial and antifungal screening of four medicinal plants. Journal of Coastal Life Medicine, 2(12), 975–979.
Aissani, N., Coroneo, V., Fattouch, S., & Caboni, P. (2012). Inhibitory effect of carob (Ceratonia siliqua) leaves methanolic extract on Listeria monocytogenes. Journal of Agricultural and Food Chemistry, 60(40), 9954–9958.
Meziani, S., Oomah, B. D., Zaidi, F., Simon-Levert, A., Bertrand, C., & Zaidi-Yahiaoui, R. (2015). Antibacterial activity of carob (Ceratonia siliqua L.) extracts against phytopathogenic bacteria Pectobacterium atrosepticum. Microbial Pathogenesis, 78, 95– 102.
Souli, A., Sebai, H., Chehimi, L., Rtibi, K., Tounsi, H., Baubaker, S., Sakly, M., El-Benna, J., Amri, M., 2013. Hepatoprotective effect of carob against acute ethanol- induced oxidative stress in rat. Toxicology and Industrial Health doi:10.1177/0748233713475506 .
Ahmed, M.M., 2010. Biochemical studies on nephroprotective effect of carob (Ceratonia siliqua L.) growing in Egypt. Nature and Science 8(3): 41- 47.
Roseiro, L. B., Duarte, L. C., Oliveira, D. L., Roque, R., Bernardo-Gil, M. G., Martins, A. I., Sepúlveda, C., Almeida, J., Meireles, M., Gírio, F. M., & Rauter, A. P. (2013). Supercritical, ultrasound and conventional extracts from carob (Ceratonia siliqua L.) biomass: Effect on the phenolic profile and antiproliferative activity. Industrial Crops and Products, 47, 132– 138.
Dhaouadi, K., Belkhir, M., Akinocho, I., Raboudi, F., Pamies, D., Barrajón, E., Estevan, C., & Fattouch, S. (2014). Sucrose supplementation during traditional carob syrup processing affected its chemical characteristics and biological activities. LWT-Food Science and Technology, 57(1), 1– 8.
Abu Hafsa, S. H., Ibrahim, S. A., & Hassan, A. A. (2017). Carob pods (Ceratonia siliqua L.) improve growth performance, antioxidant sta-tus and caecal characteristics in growing rabbits. Journal of Animal Physiology and Animal Nutrition, 101(6), 1307– 1315.
Kim, J.I., Kim, J.C., Kang, M.J., Lee, M.S., Kim, J.J., Cha, I.J., 2005. Effects of Pinitol isolated from soybeans on glycemic control and cardiovascular risk factors in Korean patients with type 2 diabetes mellitus: a randomized controlled study. European Journal of Clinical Nutrition 59: 456-458.
Gruendel, S., Otto, B., Garcia, A. L., Wagner, K., Mueller, C., Weickert, M. O., Heldwein, W., & Koebnick, C. (2007). Carob pulp preparation 3652 |IKRAMetal.rich in insoluble dietary fibre and polyphenols increases plasma glucose and serum insulin responses in combination with a glucose load in humans. British Journal of Nutrition, 98(1), 101– 105.
Sassi A, Bouhlel I, Mustapha N, et al. Assessment in vitro of the genotoxicity, antigenotoxicity and antioxidant of Ceratonia siliqua L. extracts in murine leukaemia cells L1210 by comet assay. Regul Toxicol Pharmacol 2016; 77: 117- 24.
Sarmiento-Salinas, F.L.; Delgado-Magallón, A.; Montes-Alvarado, J.B.; Ramírez-Ramírez, D.; Flores-Alonso, J.C.; Cortés-Hernández, P.; Reyes-Leyva, J.; Herrera-Camacho, I.; Anaya-Ruiz, M.; Pelayo, R.; et al. Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment. Front. Oncol. 2019, 9, 480.
Hecht, F.; Pessoa, C.F.; Gentile, L.B.; Rosenthal, D.; Carvalho, D.P.; Fortunato, R.S. The Role of Oxidative Stress on Breast Cancer Development and Therapy. Tumor Biol. 2016, 37, 4281–4291. .
Lin, Tien-Huang, et al. ‘D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways.’ International journal of molecular sciences 14.5 (2013): 9790-9802.
Custódio, Luísa, et al. ‘Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua).’ Pharmaceutical biology 47.8 (2009): 721-728.
Klenow, S., et al. ‘Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells.’ Food and Chemical Toxicology 46.4 (2008): 1389-1397.
Khazaei AH, Faramarzi A, Khazaei M. Therapeutic and functional application of ceratonia siliqua: tradition remedies and new research finding. Journal of Knowledge & Health in Basic Medical Sciences 2022;17(3):18-25. doi.org/10.22100/jkh.v17i3.2862.
Gurel, Furkan, Husamettin Ekici, and Begum Yurdakok Dikmen. ‘Cytotoxic and antitumoral effect of Ceratonia siliquracta L.(carob) extract.’ Journal of Applied Biological Sciences 15.2 (2021): 225-234.
Corsi, Lorenzo, et al. ‘Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line.’ Fitoterapia 73.7-8 (2002): 674-684.
Gregoriou, Gregoria, et al. ‘Anti-cancer activity and phenolic content of extracts derived from Cypriot carob (Ceratonia siliqua L.) pods using different solvents.’ Molecules 26.16 (2021): 5017.
Custódio, Luísa, et al. ‘In vitro cytotoxic effects and apoptosis induction by a methanol leaf extract of carob tree (Ceratonia siliqua L.).’ Journal of Medicinal Plant Research 5.10 (2011): 1987-1996.
Custódio, Luísa, et al. ‘Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts.’ Plant foods for human nutrition 66 (2011): 78-84.
Ohno, Yasushi, et al. ‘Induction of apoptosis by gallic acid in lung cancer cells.’ Anti-cancer drugs 10.9 (1999): 845-852.
Chiu, Chun‐Tang, et al. ‘Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis, and autophagy.’ Journal of food science 80.3 (2015): H649-H658.
Satoh, Motohiko, et al. ‘EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy.’ Cancer cell international 13.1 (2013): 1-8.
Elbouzidi, Amine, et al. ‘Exploring the Multi-Faceted Potential of Carob (Ceratonia siliqua var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial Activity, Cytotoxicity against Breast Cancer Cell Lines, and Genotoxicity.’ Pharmaceuticals 16.6 (2023): 840.
Pouresmaeil, Vahid, et al. ‘The anti-breast cancer effects of green-synthesized zinc oxide nanoparticles using carob extracts.’ Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 21.3 (2021): 316-326.
Stupans, Ieva, et al. ‘Inhibition of CYP3A‐mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid.’ Journal of pharmacy and pharmacology 54.2 (2002): 269-275.
Sayfalar
173-178
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Guliyev M. Keçiboynuzu (Ceratonia Siliqua). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 173-8. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13905
