Kara Kohoş Otu (Cimicifuga Racemosa)

Murray MT, Nowicki J. Cimicifuga racemosa (Black Cohosh). In: Textbook of Natural Medicine. Elsevier; 2020. p. 510-514.e1.
Mohapatra S, Iqubal A, Ansari MJ, Jan B, Zahiruddin S, Mirza MA, et al. Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review. Pharmaceuticals (Basel). 2022 Feb 23;15(3).
Castelo-Branco C, Gambacciani M, Cano A, Minkin MJ, Rachoń D, Ruan X, et al. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric. 2021 Mar 4;24(2):109–19.
Jan B, Parveen R, Zahiruddin S, Khan MU, Mohapatra S, Ahmad S. Nutritional constituents of mulberry and their potential applications in food and pharmaceuticals: A review. Saudi J Biol Sci. 2021 Jul;28(7):3909–21.
Kruse S, Löhning A, Pauli G, Winterhoff H, Nahrstedt A. Fukiic and Piscidic Acid Esters from the Rhizome of Cimicifuga racemosa and the in vitro Estrogenic Activity of Fukinolic Acid. Planta Med. 1999 Dec 4;65(08):763–4.
Li W, Chen S, Fabricant D, Angerhofer CK, Fong HHS, Farnsworth NR, et al. High-performance liquid chromatographic analysis of Black Cohosh (Cimicifuga racemosa) constituents with in-line evaporative light scattering and photodiode array detection. Anal Chim Acta. 2002 Oct;471(1):61–75.
Avula B, Wang YH, Smillie T, Khan I. Quantitative Determination of Triterpenoids and Formononetin in Rhizomes of Black Cohosh ( Actaea racemosa ) and Dietary Supplements by Using UPLC-UV/ELS Detection and Identification by UPLC-MS. Planta Med. 2009 Mar 5;75(04):381–6.
He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, et al. Cimicifuga species identification by high performance liquid chromatography–photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products. J Chromatogr A. 2006 Apr;1112(1–2):241–54.
Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer. 2007 May 19;7(5):357–69.
Burdette JE, Chen S nong, Lu ZZ, Xu H, White BEP, Fabricant DS, et al. Black Cohosh ( Cimicifuga racemosa L.) Protects against Menadione-Induced DNA Damage through Scavenging of Reactive Oxygen Species: Bioassay-Directed Isolation and Characterization of Active Principles. J Agric Food Chem. 2002 Nov 1;50(24):7022–8.
Jiang B, Kronenberg F, Balick MJ, Kennelly EJ. Stability of black cohosh triterpene glycosides and polyphenols: Potential clinical relevance. Phytomedicine. 2013 Apr;20(6):564–9.
Leach MJ, Moore V. Black cohosh ( Cimicifuga spp.) for menopausal symptoms. Cochrane Database of Systematic Reviews. 2012 Sep 12;
Avula B, Wang YH, Smillie T, Khan I. Quantitative Determination of Triterpenoids and Formononetin in Rhizomes of Black Cohosh ( Actaea racemosa ) and Dietary Supplements by Using UPLC-UV/ELS Detection and Identification by UPLC-MS. Planta Med. 2009 Mar 5;75(04):381–6.
Struck D, Tegtmeier M, Harnischfeger G. Flavones in Extracts of Cimicifuga racemosa. Planta Med. 1997 Jun 4;63(03):289–289.
Jiang B, Kronenberg F, Balick MJ, Kennelly EJ. Analysis of formononetin from black cohosh (Actaea racemosa). Phytomedicine. 2006 Jul;13(7):477–86.
Wuttke W, Gorkow C, Jarry H. Dopaminergic compounds in Vitex agnus castus, Loew, DRietbrock, N, Phytopharmaka in Forschung und klinischer Anwendung. Steinkopf Verlag, Darmstadt. 1995;81:91.
Panossian A, Danielyan A, Mamikonyan G, Wikman G. Methods of phytochemical standardisation of rhizoma Cimicifugae racemosae. Phytochemical Analysis. 2004 Mar 22;15(2):100–8.
Li W, Chen S, Fabricant D, Angerhofer CK, Fong HH, Farnsworth NR, Fitzloff JF. High-performance liquid chromatographic analysis of Black Cohosh (Cimicifuga racemosa) constituents with in-line evaporative light scattering and photodiode array detection. Analytica Chimica Acta. 2002 Oct 23;471(1):61-75.
Kennelly EJ, Baggett S, Nuntanakorn P, Ososki AL, Mori SA, Duke J, et al. Analysis of thirteen populations of Black Cohosh for formononetin. Phytomedicine. 2002 Jan;9(5):461–7.
Jiang B, Kronenberg F, Nuntanakorn P, Qiu MH, Kennelly EJ. Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry. J Agric Food Chem. 2006 May 1;54(9):3242–53.
Nikolić D, Lankin DC, Cisowska T, Chen SN, Pauli GF, van Breemen RB. Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities. In: The Formation, Structure and Activity of Phytochemicals. Cham: Springer International Publishing; 2015. p. 31–75.
Burdette JE, Liu J, Chen S nong, Fabricant DS, Piersen CE, Barker EL, et al. Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor. J Agric Food Chem. 2003 Sep 1;51(19):5661–70.
Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, et al. In Vitro Serotonergic Activity of Black Cohosh and Identification of N ω -Methylserotonin as a Potential Active Constituent. J Agric Food Chem. 2008 Dec 24;56(24):11718–26.
Mohapatra S, Iqubal A, Ansari MJ, Jan B, Zahiruddin S, Mirza MA, et al. Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review. Pharmaceuticals. 2022 Feb 23;15(3):278.
Nikolić D, Gödecke T, Chen SN, White J, Lankin DC, Pauli GF, et al. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia. 2012 Apr;83(3):441–60.
Mohapatra S, Iqbal Z, Ahmad S, Kohli K, Farooq U, Padhi S, et al. Menopausal Remediation and Quality of Life (QoL) Improvement: Insights and Perspectives. Endocr Metab Immune Disord Drug Targets. 2020 Dec 2;20(10):1624–36.
Qiu SX, Dan C, Ding LS, Peng S, Chen SN, Farnsworth NR, et al. A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways. Chem Biol. 2007 Jul;14(7):860–9.
Winterhoff H, Spengler B, Christoffel V, Butterweck V, Löhning A. Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity. Maturitas. 2003 Mar;44:S51–8.
Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. Journal of Agricultural and Food Chemistry. 2003 Sep 10;51(19):5661-70.
Kretzschmar G, Nisslein T, Zierau O, Vollmer G. No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment. The Journal of Steroid Biochemistry and Molecular Biology. 2005 Nov 1;97(3):271-7.
Zierau O, Bodinet C, Kolba S, Wulf M, Vollmer G. Antiestrogenic activities of Cimicifuga racemosa extracts. The Journal of steroid biochemistry and molecular biology. 2002 Jan 1;80(1):125-30.
Liske E, Hänggi W, Henneicke-von Zepelin HH, Boblitz N, Wüstenberg P, Rahlfs VW. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. Journal of women’s health & gender-based medicine. 2002 Mar 1;11(2):163-74.
Wuttke W, Gorkow C, Seidlová-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women. Menopause. 2006 Mar;13(2):185–96.
Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003 Mar;44:S67–77.
Szmyd M, Lloyd V, Hallman K, Aleck K, Mladenovik V, McKee C, et al. The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells. Breast Cancer: Targets and Therapy. 2018 Jan;Volume 10:1–11.
Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: A randomized study versus low-dose transdermal estradiol. Gynecological Endocrinology. 2005 Jan 7;20(1):30–5.
Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin HH. Efficacy and Safety of Isopropanolic Black Cohosh Extract for Climacteric Symptoms. Obstetrics & Gynecology. 2005 May;105(5, Part 1):1074–83.
Guida M, Raffone A, Travaglino A, Neola D, Reppuccia S, Borgo M, et al. Cimicifuga racemosa isopropanolic extract for menopausal symptoms: an observational prospective case–control study. Gynecological Endocrinology. 2021 Dec 2;37(12):1132–7.
Seidlova-Wuttke D, Stecher G, Kammann M, Haunschild J, Eder N, Stahnke V, et al. Osteoprotective effects of Cimicifuga racemosa and its triterpene-saponins are responsible for reduction of bone marrow fat. Phytomedicine. 2012 Jul;19(10):855–60.
Cui G, Leng H, Wang K, Wang J, Zhu S, Jia J, et al. Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis. PLoS One. 2013 Dec 9;8(12):e82815.
Li JX, Liu J, He CC, Yu ZY, Du Y, Kadota S, et al. Triterpenoids from Cimicifugae rhizoma, a novel class of inhibitors on bone resorption and ovariectomy-induced bone loss. Maturitas. 2007 Sep;58(1):59–69.
Zakir F, Ahmad A, Farooq U, Mirza MA, Tripathi A, Singh D, et al. Design and development of a commercially viable in situ nanoemulgel for the treatment of postmenopausal osteoporosis. Nanomedicine. 2020 May;15(12):1167–87.
Choi EM. Deoxyactein stimulates osteoblast function and inhibits bone‐resorbing mediators in MC3T3‐E1 cells. Journal of Applied Toxicology. 2013 Mar 9;33(3):190–5.
Lee YS, Choi EM. Actein Isolated from Black Cohosh Promotes the Function of Osteoblastic MC3T3-E1 Cells. J Med Food. 2014 Apr;17(4):414–23.
Einbond LS, Soffritti M, Degli Esposti D, Tibaldi E, Lauriola M, Bua L, et al. Chemopreventive potential of black cohosh on breast cancer in Sprague-Dawley rats. Anticancer Res. 2012 Jan;32(1):21–30.
Lundström E, Hirschberg AL, Söderqvist G. Digitized assessment of mammographic breast density – Effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo. Maturitas. 2011 Dec;70(4):361–4.
Hirschberg AL, Edlund M, Svane G, Azavedo E, Skoog L, von Schoultz B. An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women. Menopause. 2007 Jan;14(1):89–96.
Bodinet C, Freudenstein J. Influence of Cimicifuga Racemosa on the Proliferation of Estrogen Receptor-Positive Human Breast Cancer Cells. Breast Cancer Res Treat. 2002 Nov;76(1):1–10.
Freudenstein J, Dasenbrock C, Nisslein T. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res. 2002 Jun 15;62(12):3448–52.
Ruan X, Mueck AO, Beer AM, Naser B, Pickartz S. Benefit–risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John’s wort in breast cancer patients. Climacteric. 2019 Jul 4;22(4):339–47.
Li J, Gödecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, et al. In vitro metabolic interactions between black cohosh ( Cimicifuga racemosa ) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica. 2011 Dec 9;41(12):1021–30.
Fan CW, Cieri-Hutcherson NE, Hutcherson TC. Systematic Review of Black Cohosh ( Cimicifuga racemosa ) for Management of Polycystic Ovary Syndrome-Related Infertility. J Pharm Pract. 2022 Dec 29;35(6):991–9.
Jiang G. Efficacy and Safety of Remifemin on Peri-Menopausal Symptoms Induced by Post-Operative GnRH-a Therapy for Endometriosis: A Randomized Study versus Tibolone. Medical Science Monitor. 2014;20:1950–7.
Borrelli F, Izzo AA, Ernst E. Pharmacological effects of Cimicifuga racemosa. Life Sci. 2003 Jul;73(10):1215–29.
Walji R, Boon H, Guns E, Oneschuk D, Younus J. Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients. Supportive Care in Cancer. 2007 Aug 13;15(8):913–21.
Lüde S, Török M, Dieterle S, Knapp AC, Kaeufeler R, Jäggi R, et al. Hepatic effects of Cimicifuga racemosa extract in vivo and in vitro. Cellular and Molecular Life Sciences. 2007 Nov 12;64(21):2848–57.
Sinreih M, Gregorič K, Gajser K, Rižner TL. Physiological Concentrations of Cimicifuga racemosa Extract Do Not Affect Expression of Genes Involved in Estrogen Biosynthesis and Action in Endometrial and Ovarian Cell Lines. Biomolecules. 2022 Apr 5;12(4):545.