Endometriozis Biyobelirteçleri
Synopsis
Endometriozis için klinik olarak güvenilir, invaziv olmayan bir testin tanı gecikmesini azaltması bekleniyor. Çeşitli biyo-belirteçler onlarca yıldır araştırılmış olsa da ve kanser antijeni-125, kanser antijeni-199, interlökin-6 ve ürokortin yüzlerce biyo-belirteç arasında en çok çalışılanlar olsa da klinik olarak güvenilir biyo-belirteçler doğrulanmamıştır. Bazı yeni teknolojiler, moleküler görüntüleme teknikleri ve mikroRNA'lar bu zorlukları çözmede umut vadediyor ancak endometriozisi tespit etmedeki faydaları henüz doğrulanmadı. Araştırılan göstergelerin veya diğer invaziv olmayan yöntemlerin yeni kombinasyonları ve yeni teknolojilerin daha fazla araştırılması, endometriozisin invaziv olmayan tanısı için yeni hedefler ve gelecekteki araştırma odak noktaları olabilir. Sonuç olarak, endometriozisi tespit etmek için biyo-belirteçler üzerine araştırmalar devam etmektedir ve yeni moleküler biyoloji, biyoenformatik yöntemler ve daha çeşitli izleme yöntemlerinin bir kombinasyonundan faydalanabilir. Zorlayıcı olsa da belirli bir tanı biyo-belirteci setini belirlemek şüphesiz endometriozis durumunu iyileştirecektir.
A clinically reliable, non-invasive test for endometriosis is expected to reduce the diagnostic delay. Although various biomarkers have been investigated for decades, and cancer antigen-125, cancer antigen-199, interleukin-6, and urocortin were the most studied among hundreds of biomarkers, no clinically reliable biomarkers have been confirmed. Some emerging technologies, molecular imaging techniques, and microRNAs, are promising in solving these challenges, but their utility to detect endometriosis has yet to be verified. New combinations of researched indicators or other non-invasive methods and further exploration of emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of endometriosis. In conclusion, research on biomarkers for detecting endometriosis is ongoing and may benefit from novel molecular biology, bioinformatics methods, and a combination of more diverse monitoring methods. Though it will be daunting, identifying a specific set of diagnostic biomarkers will undoubtedly improve endometriosis status.
References
Crump J, Suker A, White L. Endometriosis: A review of recent evidence and guidelines. Aust J Gen Pract. 2024;53(1-2):11-18. doi:10.31128/AJGP/04-23-6805
Pašalić E, Tambuwala MM, Hromić-Jahjefendić A. Endometriosis: Classification, pathophysiology, and treatment options. Pathol Res Pract. 2023;251:154847. doi:10.1016/j.prp.2023.154847
Young SL. Nonsurgical approaches to the diagnosis and evaluation of endometriosis. Fertil Steril. 2024;121(2):140-144. doi:10.1016/j.fertnstert.2023.12.020
Volpini C, Bloise N, Dominoni M, et al. The nano-revolution in the diagnosis and treatment of endometriosis. Nanoscale. 2023;15(43):17313-17325. Published 2023 Nov 9. doi:10.1039/d3nr03527a
Adilbayeva A, Kunz J. Pathogenesis of Endometriosis and Endometriosis-Associated Cancers. Int J Mol Sci. 2024;25(14):7624. Published 2024 Jul 11. doi:10.3390/ijms25147624
Li Q, Shi J, Yi D, et al. The pathogenesis of endometriosis and adenomyosis: insights from single-cell RNA sequencing†. Biol Reprod. 2024;110(5):854-865. doi:10.1093/biolre/ioae032
Vercellini P, Salmeri N, Somigliana E, et al. Müllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation/implantation and the embryonic remnants/celomic metaplasia pathogenic theories: a systematic review and meta-analysis. Hum Reprod. Published online May 10, 2024. doi:10.1093/humrep/deae086
Eggers JC, Martino V, Reinbold R, et al. microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4. Reprod Biomed Online. 2016;32(4):434-445. doi:10.1016/j.rbmo.2015.12.013
Feng Y, Dong H, Tan B. Endometriotic mesenchymal stem cells promote the fibrosis process of endometriosis through paracrine TGF-β1 mediated RASAL1 inhibition. J Obstet Gynaecol Res. 2024;50(3):467-477. doi:10.1111/jog.15851
Oală IE, Mitranovici MI, Chiorean DM, et al. Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature. Diagnostics (Basel). 2024;14(3):312. Published 2024 Jan 31. doi:10.3390/diagnostics14030312
Mokhtari T, Irandoost E, Sheikhbahaei F. Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation. Int Immunopharmacol. 2024;132:111942. doi:10.1016/j.intimp.2024.111942
Cuffaro F, Russo E, Amedei A. Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread. Int J Mol Sci. 2024;25(12):6473. Published 2024 Jun 12. doi:10.3390/ijms25126473
Bo C, Wang Y. Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review). Mol Med Rep. 2024;29(3):43. doi:10.3892/mmr.2024.13167
Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. Endocrinology. 2008;149(3):1180-1189. doi:10.1210/en.2007-1168
Zhang M, Xu T, Tong D, et al. Research advances in endometriosis-related signaling pathways: A review. Biomed Pharmacother. 2023;164:114909. doi:10.1016/j.biopha.2023.114909
Zeller JM, Henig I, Radwanska E, Dmowski WP. Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immunol Microbiol. 1987;13(3):78-82. doi:10.1111/j.1600-0897.1987.tb00097.x
Portz DM, Elkins TE, White R, Warren J, Adadevoh S, Randolph J. Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int J Fertil. 1991;36(1):39-42.
Laganà AS, Salmeri FM, Ban Frangež H, Ghezzi F, Vrtačnik-Bokal E, Granese R. Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease. Gynecol Endocrinol. 2020;36(5):441-444. doi:10.1080/09513590.2019.1683821
Farolfi A, Gentili N, Testoni S, et al. Endometriosis and endometrial cancer: A propensity score-adjusted real-world data study. iScience. 2024;27(5):109680. Published 2024 Apr 6. doi:10.1016/j.isci.2024.109680
Wu MY, Yang JH, Chao KH, Hwang JL, Yang YS, Ho HN. Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. Fertil Steril. 2000;74(6):1187-1191. doi:10.1016/s0015-0282(00)01592-2
Nie MF, Xie Q, Wu YH, et al. Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway. J Immunol Res. 2018;2018:6285813. Published 2018 Sep 12. doi:10.1155/2018/6285813
Brulport A, Bourdon M, Vaiman D, et al. An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review. Reprod Biol Endocrinol. 2024;22(1):21. Published 2024 Feb 10. doi:10.1186/s12958-023-01181-8
Filindris T, Papakonstantinou E, Keramida M, et al. The effect of GnRH-a on the angiogenesis of endometriosis. Hormones (Athens). Published online April 19, 2024. doi:10.1007/s42000-024-00559-6
Volpert OV, Fong T, Koch AE, et al. Inhibition of angiogenesis by interleukin 4. J Exp Med. 1998;188(6):1039-1046. doi:10.1084/jem.188.6.1039
Torisu H, Ono M, Kiryu H, et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha. Int J Cancer. 2000;85(2):182-188.
Donnez J, Smoes P, Gillerot S, Casanas-Roux F, Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod. 1998;13(6):1686-1690. doi:10.1093/humrep/13.6.1686
Kovalak EE, Karacan T, Zengi O, Karabay Akgül Ö, Özyürek ŞE, Güraslan H. Evaluation of new biomarkers in stage III and IV endometriosis. Gynecol Endocrinol. 2023;39(1):2217290. doi:10.1080/09513590.2023.2217290
Pretice Crapper, E. Clinical Biomarkers for the Noninvasive Diagnosis of Endometriosis. 2016. Available online: http://hdl.handle.net/11375/20495 (accessed on 26 February 2020).
Reis FM, Luisi S, Abrão MS, et al. Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Hum Reprod. 2012;27(5):1445-1450. doi:10.1093/humrep/des055
Cardoso JV, Machado DE, da Silva MC, et al. Influence of interleukin-8 polymorphism on endometriosis-related pelvic pain. Hum Immunol. 2023;84(10):561-566. doi:10.1016/j.humimm.2023.07.004
Cho SH, Oh YJ, Nam A, et al. Evaluation of serum and urinary angiogenic factors in patients with endometriosis. Am J Reprod Immunol. 2007;58(6):497-504. doi:10.1111/j.1600-0897.2007.00535.x
Wang X, Jiang X, Lv X, Wang X, Lin A, Li Y. NADPH oxidase 4-mediating oxidative stress contributes to endometriosis. J Appl Genet. 2024;65(1):113-120. doi:10.1007/s13353-023-00810-7
Fekri S, Makoui RH, Ansari N, Makoui MH. Correlation between the existence of serum autoantibodies and the risk of endometriosis: A systematic review and meta-analysis. Turk J Obstet Gynecol. 2024;21(2):104-117. doi:10.4274/tjod.galenos.2024.77489
Long X, Jiang P, Zhou L, Zhang W. Evaluation of novel serum biomarkers and the proteomic differences of endometriosis and adenomyosis using MALDI-TOF-MS. Arch Gynecol Obstet. 2013;288(1):201-205. doi:10.1007/s00404-012-2700-0
Wölfler MM, Schwamborn K, Otten D, Hornung D, Liu H, Rath W. Mass spectrometry and serum pattern profiling for analyzing the individual risk for endometriosis: promising insights?. Fertil Steril. 2009;91(6):2331-2337. doi:10.1016/j.fertnstert.2008.03.064
Chandrakanth A, Firdous S, Vasantharekha R, Santosh W, Seetharaman B. Exploring the Effects of Endocrine-Disrupting Chemicals and miRNA Expression in the Pathogenesis of Endometriosis by Unveiling the Pathways: a Systematic Review. Reprod Sci. 2024;31(4):932-941. doi:10.1007/s43032-023-01412-8
Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010;16(2):142-165. doi:10.1093/humupd/dmp034
Kuessel L, Jaeger-Lansky A, Pateisky P, et al. Cytokeratin-19 as a biomarker in urine and in serum for the diagnosis of endometriosis--a prospective study. Gynecol Endocrinol. 2014;30(1):38-41. doi:10.3109/09513590.2013.856409
Becker CM, Louis G, Exarhopoulos A, et al. Matrix metalloproteinases are elevated in the urine of patients with endometriosis. Fertil Steril. 2010;94(6):2343-2346. doi:10.1016/j.fertnstert.2010.02.040
Chen X, Liu H, Sun W, Guo Z, Lang J. Elevated urine histone 4 levels in women with ovarian endometriosis revealed by discovery and parallel reaction monitoring proteomics. J Proteomics. 2019;204:103398. doi:10.1016/j.jprot.2019.103398
Pašalić E, Tambuwala MM, Hromić-Jahjefendić A. Endometriosis: Classification, pathophysiology, and treatment options. Pathol Res Pract. 2023;251:154847. doi:10.1016/j.prp.2023.154847
Young SL. Nonsurgical approaches to the diagnosis and evaluation of endometriosis. Fertil Steril. 2024;121(2):140-144. doi:10.1016/j.fertnstert.2023.12.020
Volpini C, Bloise N, Dominoni M, et al. The nano-revolution in the diagnosis and treatment of endometriosis. Nanoscale. 2023;15(43):17313-17325. Published 2023 Nov 9. doi:10.1039/d3nr03527a
Adilbayeva A, Kunz J. Pathogenesis of Endometriosis and Endometriosis-Associated Cancers. Int J Mol Sci. 2024;25(14):7624. Published 2024 Jul 11. doi:10.3390/ijms25147624
Li Q, Shi J, Yi D, et al. The pathogenesis of endometriosis and adenomyosis: insights from single-cell RNA sequencing†. Biol Reprod. 2024;110(5):854-865. doi:10.1093/biolre/ioae032
Vercellini P, Salmeri N, Somigliana E, et al. Müllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation/implantation and the embryonic remnants/celomic metaplasia pathogenic theories: a systematic review and meta-analysis. Hum Reprod. Published online May 10, 2024. doi:10.1093/humrep/deae086
Eggers JC, Martino V, Reinbold R, et al. microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4. Reprod Biomed Online. 2016;32(4):434-445. doi:10.1016/j.rbmo.2015.12.013
Feng Y, Dong H, Tan B. Endometriotic mesenchymal stem cells promote the fibrosis process of endometriosis through paracrine TGF-β1 mediated RASAL1 inhibition. J Obstet Gynaecol Res. 2024;50(3):467-477. doi:10.1111/jog.15851
Oală IE, Mitranovici MI, Chiorean DM, et al. Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature. Diagnostics (Basel). 2024;14(3):312. Published 2024 Jan 31. doi:10.3390/diagnostics14030312
Mokhtari T, Irandoost E, Sheikhbahaei F. Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation. Int Immunopharmacol. 2024;132:111942. doi:10.1016/j.intimp.2024.111942
Cuffaro F, Russo E, Amedei A. Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread. Int J Mol Sci. 2024;25(12):6473. Published 2024 Jun 12. doi:10.3390/ijms25126473
Bo C, Wang Y. Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review). Mol Med Rep. 2024;29(3):43. doi:10.3892/mmr.2024.13167
Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. Endocrinology. 2008;149(3):1180-1189. doi:10.1210/en.2007-1168
Zhang M, Xu T, Tong D, et al. Research advances in endometriosis-related signaling pathways: A review. Biomed Pharmacother. 2023;164:114909. doi:10.1016/j.biopha.2023.114909
Zeller JM, Henig I, Radwanska E, Dmowski WP. Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immunol Microbiol. 1987;13(3):78-82. doi:10.1111/j.1600-0897.1987.tb00097.x
Portz DM, Elkins TE, White R, Warren J, Adadevoh S, Randolph J. Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int J Fertil. 1991;36(1):39-42.
Laganà AS, Salmeri FM, Ban Frangež H, Ghezzi F, Vrtačnik-Bokal E, Granese R. Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease. Gynecol Endocrinol. 2020;36(5):441-444. doi:10.1080/09513590.2019.1683821
Farolfi A, Gentili N, Testoni S, et al. Endometriosis and endometrial cancer: A propensity score-adjusted real-world data study. iScience. 2024;27(5):109680. Published 2024 Apr 6. doi:10.1016/j.isci.2024.109680
Wu MY, Yang JH, Chao KH, Hwang JL, Yang YS, Ho HN. Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. Fertil Steril. 2000;74(6):1187-1191. doi:10.1016/s0015-0282(00)01592-2
Nie MF, Xie Q, Wu YH, et al. Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway. J Immunol Res. 2018;2018:6285813. Published 2018 Sep 12. doi:10.1155/2018/6285813
Brulport A, Bourdon M, Vaiman D, et al. An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review. Reprod Biol Endocrinol. 2024;22(1):21. Published 2024 Feb 10. doi:10.1186/s12958-023-01181-8
Filindris T, Papakonstantinou E, Keramida M, et al. The effect of GnRH-a on the angiogenesis of endometriosis. Hormones (Athens). Published online April 19, 2024. doi:10.1007/s42000-024-00559-6
Volpert OV, Fong T, Koch AE, et al. Inhibition of angiogenesis by interleukin 4. J Exp Med. 1998;188(6):1039-1046. doi:10.1084/jem.188.6.1039
Torisu H, Ono M, Kiryu H, et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha. Int J Cancer. 2000;85(2):182-188.
Donnez J, Smoes P, Gillerot S, Casanas-Roux F, Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod. 1998;13(6):1686-1690. doi:10.1093/humrep/13.6.1686
Kovalak EE, Karacan T, Zengi O, Karabay Akgül Ö, Özyürek ŞE, Güraslan H. Evaluation of new biomarkers in stage III and IV endometriosis. Gynecol Endocrinol. 2023;39(1):2217290. doi:10.1080/09513590.2023.2217290
Pretice Crapper, E. Clinical Biomarkers for the Noninvasive Diagnosis of Endometriosis. 2016. Available online: http://hdl.handle.net/11375/20495 (accessed on 26 February 2020).
Reis FM, Luisi S, Abrão MS, et al. Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Hum Reprod. 2012;27(5):1445-1450. doi:10.1093/humrep/des055
Cardoso JV, Machado DE, da Silva MC, et al. Influence of interleukin-8 polymorphism on endometriosis-related pelvic pain. Hum Immunol. 2023;84(10):561-566. doi:10.1016/j.humimm.2023.07.004
Cho SH, Oh YJ, Nam A, et al. Evaluation of serum and urinary angiogenic factors in patients with endometriosis. Am J Reprod Immunol. 2007;58(6):497-504. doi:10.1111/j.1600-0897.2007.00535.x
Wang X, Jiang X, Lv X, Wang X, Lin A, Li Y. NADPH oxidase 4-mediating oxidative stress contributes to endometriosis. J Appl Genet. 2024;65(1):113-120. doi:10.1007/s13353-023-00810-7
Fekri S, Makoui RH, Ansari N, Makoui MH. Correlation between the existence of serum autoantibodies and the risk of endometriosis: A systematic review and meta-analysis. Turk J Obstet Gynecol. 2024;21(2):104-117. doi:10.4274/tjod.galenos.2024.77489
Long X, Jiang P, Zhou L, Zhang W. Evaluation of novel serum biomarkers and the proteomic differences of endometriosis and adenomyosis using MALDI-TOF-MS. Arch Gynecol Obstet. 2013;288(1):201-205. doi:10.1007/s00404-012-2700-0
Wölfler MM, Schwamborn K, Otten D, Hornung D, Liu H, Rath W. Mass spectrometry and serum pattern profiling for analyzing the individual risk for endometriosis: promising insights?. Fertil Steril. 2009;91(6):2331-2337. doi:10.1016/j.fertnstert.2008.03.064
Chandrakanth A, Firdous S, Vasantharekha R, Santosh W, Seetharaman B. Exploring the Effects of Endocrine-Disrupting Chemicals and miRNA Expression in the Pathogenesis of Endometriosis by Unveiling the Pathways: a Systematic Review. Reprod Sci. 2024;31(4):932-941. doi:10.1007/s43032-023-01412-8
Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010;16(2):142-165. doi:10.1093/humupd/dmp034
Kuessel L, Jaeger-Lansky A, Pateisky P, et al. Cytokeratin-19 as a biomarker in urine and in serum for the diagnosis of endometriosis--a prospective study. Gynecol Endocrinol. 2014;30(1):38-41. doi:10.3109/09513590.2013.856409
Becker CM, Louis G, Exarhopoulos A, et al. Matrix metalloproteinases are elevated in the urine of patients with endometriosis. Fertil Steril. 2010;94(6):2343-2346. doi:10.1016/j.fertnstert.2010.02.040
Chen X, Liu H, Sun W, Guo Z, Lang J. Elevated urine histone 4 levels in women with ovarian endometriosis revealed by discovery and parallel reaction monitoring proteomics. J Proteomics. 2019;204:103398. doi:10.1016/j.jprot.2019.103398
Pages
169-177
Published
January 21, 2025
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