C-Reaktif Protein/Albümin Oranının Fizyolojik ve Klinik Önemi
Synopsis
İnflamasyon ve beslenme durumu, çeşitli fizyolojik süreçleri etkileyen sağlık ve hastalığın kritik belirleyicileridir. Karaciğer tarafından inflamatuar sitokinlere yanıt olarak üretilen ve sistemik inflamasyonun hassas bir belirteci olarak görev yapan bir akut faz reaktanı olan CRP ve beslenme durumu, inflamasyon ve genel sağlığı yansıtan çok işlevli bir protein olan albümin, bir bireyin fizyolojik ve klinik durumu hakkında değerli bilgiler sunar. Son yıllarda C-reaktif proteinin (CRP) albümin düzeylerine oranı olarak hesaplanan CRP/albümin oranı; sistemik inflamasyon, beslenme durumu, sağlık durumu, hastalığın teşhisi, hastalığın ilerlemesi ve tedaviye yanıt konusunda değerli bilgiler sunan, çeşitli tıbbi durumlarda potansiyel prognostik ve prediktif değeri olan, fizyolojik öneme sahip, dikkate değer ve umut verici bir biyobelirteç olarak öne çıkmaktadır. C-reaktif protein/albümin oranının klinik kullanımı, çeşitli tıbbi durumlarda tanı, hastalık patogenezi, hastalık aktivitesi, prognoz ve tedaviye yanıt hakkında değerli bilgiler sunar.
Inflammation and nutritional status are critical determinants of health and disease that affect various physiological processes. CRP, an acute phase reactant produced by the liver in response to inflammatory cytokines and acting as a sensitive marker of systemic inflammation, and albumin, a multifunctional protein reflecting nutritional status, inflammation, and general health, provide valuable information about an individual's physiological and clinical status. In recent years, the CRP/albumin ratio, calculated as the ratio of C-reactive protein (CRP) to albumin levels, a remarkable and promising biomarker of physiological importance, providing valuable information about systemic inflammation, nutritional status, health status, disease diagnosis, disease progression, and response to treatment, and has potential prognostic and predictive value in various medical conditions. The clinical use of the C-reactive protein/albumin ratio provides valuable information about diagnosis, disease pathogenesis, disease activity, prognosis, and response to treatment in various medical conditions.
References
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Jia-Min Z, Wei D, Ye L, Xiang-Tao P. Correlation between C-reactive protein/albumin ratio and prognosis in patients with lung adenocarcinoma. J Int Med Res. 2022;50(6):3000605221105372. doi: 10.1177/03000605221105372.
Gao M, Zhang C, Gao L, Sun S, Song L, Liu S. Association between C-reactive protein-albumin ratio and overall survival in Parkinson's disease using publicly available data: A retrospective cohort study. Heliyon. 2023;9(2):e12671. doi: 10.1016/j.heliyon.2022.e12671.
Tillett WS, Francis T. Serologıcal reactıons ın pneumonıa wıth a non-proteın somatıc fractıon of pneumococcus. J Exp Med. 1930;52(4):561-71. doi: 10.1084/jem.52.4.561.
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Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. doi: 10.3389/fimmu.2018.00754.
Calabró P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003;108(16):1930-2. doi: 10.1161/01.CIR.0000096055.62724.
Devaraj S, Singh U, Jialal I. The evolving role of C-reactive protein in atherothrombosis. Clin Chem. 2009;55(2):229-38. doi: 10.1373/clinchem.2008.108886.
Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102(18):2165-8. doi: 10.1161/01.cir.102.18.2165.
Calabro P, Chang DW, Willerson JT, Yeh ET. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol. 2005;46(6):1112-3. doi: 10.1016/j.jacc.2005.06.017.
Kaplan MH, Volanakis JE. Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol. 1974 Jun;112(6):2135-47.
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Kingsley A, Jones V. Diagnosing wound infection: the use of C-reactive protein. Wounds Uk, 2008; 4(4): 32-46.
Fang P, Shi M, Yu M, Guo L, Bo P, Zhang Z. Endogenous peptides as risk markers to assess the development of insulin resistance. Peptides. 2014;51:9-14. doi: 10.1016/j.peptides.2013.10.025.
Ding Z, Wei Y, Peng J, Wang S, Chen G, Sun J. The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging. Biomedicines. 2023;11(10):2711. doi: 10.3390/biomedicines11102711.
Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis. 2009;206(1):61-8. doi: 10.1016/j.atherosclerosis.2009.02.002.
Hage FG, Szalai AJ. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol. 2007;50(12):1115-22. doi: 10.1016/j.jacc.2007.06.012.
Osman R, L'Allier PL, Elgharib N, Tardif JC. Critical appraisal of C-reactive protein throughout the spectrum of cardiovascular disease. Vasc Health Risk Manag. 2006;2(3):221-37. doi: 10.2147/vhrm.2006.2.3.221.
Enocsson H, Karlsson J, Li HY, Wu Y, Kushner I, Wetterö J, Sjöwall C. The Complex Role of C-Reactive Protein in Systemic Lupus Erythematosus. J Clin Med. 2021;10(24):5837. doi: 10.3390/jcm10245837.
Atas DB, Sahin GK, Şengül Ş, Kaya B, Paydaş S, Alibaz-Oner F, Direskeneli H, Tuglular S, Asicioglu E. C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis. Mediterr J Rheumatol. 2023;34(1):71-77. doi: 10.31138/mjr.34.1.71.
Largman-Chalamish M, Wasserman A, Silberman A, Levinson T, Ritter O, Berliner S, Zeltser D, Shapira I, Rogowski O, Shenhar-Tsarfaty S. Differentiating between bacterial and viral infections by estimated CRP velocity. PLoS One. 2022;17(12):e0277401. doi: 10.1371/journal.pone.0277401.
Cao Y, Yao X. Acute albumin administration as therapy for intracerebral hemorrhage: A literature review. Heliyon. 2023;10(1):e23946. doi: 10.1016/j.heliyon.2023.e23946.
Spada A, Emami J, Tuszynski JA, Lavasanifar A. The Uniqueness of Albumin as a Carrier in Nanodrug Delivery. Mol Pharm. 2021;18(5):1862-1894. doi: 10.1021/acs.molpharmaceut.1c00046.
Chien SC, Chen CY, Lin CF, Yeh HI. Critical appraisal of the role of serum albumin in cardiovascular disease. Biomark Res. 2017;5:31. doi: 10.1186/s40364-017-0111-x.
Keller U. Nutritional Laboratory Markers in Malnutrition. J Clin Med. 2019;8(6):775. doi: 10.3390/jcm8060775.
Ohwada H, Nakayama T, Kanaya Y, Tanaka Y. Serum albumin levels and their correlates among individuals with motor disorders at five institutions in Japan. Nutr Res Pract. 2017;11(1):57-63. doi: 10.4162/nrp.2017.11.1.57.
Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients. Am J Med. 2017;130(12):1465.e11-1465.e19. doi: 10.1016/j.amjmed.2017.07.020.
Kaplan M, Ates I, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, Coskun O, Kayacetin E. Predictive value of C-reactive protein/albumin ratio in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2017;16(4):424-430. doi: 10.1016/S1499-3872(17)60007-9.
Öçal R, Akın Öçal FC, Güllüev M, Alataş N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86(2):180-184. doi: 10.1016/j.bjorl.2018.10.007.
Cacciola G, Mancino F, Holzer LA, De Meo F, De Martino I, Bruschetta A, Risitano S, Sabatini L, Cavaliere P. Predictive Value of the C-Reactive Protein to Albumin Ratio in 30-Day Mortality after Hip Fracture in Elderly Population: A Retrospective Observational Cohort Study. J Clin Med. 2023;12(13):4544. doi: 10.3390/jcm12134544.
Liu Y, Gao Y, Liang B, Liang Z. The prognostic value of C-reactive protein to albumin ratio in patients with sepsis: a systematic review and meta-analysis. Aging Male. 2023;26(1):2261540. doi: 10.1080/13685538.2023.2261540.
Yang X, Yang X, Yang J, Wen X, Wu S, Cui L. High levels of high-sensitivity C reactive protein to albumin ratio can increase the risk of cardiovascular disease. J Epidemiol Community Health. 2023;77(11):721-727. doi: 10.1136/jech-2023-220760.
He D, Yang Y, Yang Y, Tang X, Huang K. Prognostic significance of preoperative C-reactive protein to albumin ratio in non-small cell lung cancer patients: A meta-analysis. Front Surg. 2023;9:1056795. doi: 10.3389/fsurg.2022.1056795.
Chen YH, Wang L, Feng SY, Cai WM, Chen XF, Huang ZM. The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease. Gastroenterol Res Pract. 2020;2020:3467419. doi: 10.1155/2020/3467419.
Yang WM, Zhang WH, Ying HQ, Xu YM, Zhang J, Min QH, Huang B, Lin J, Chen JJ, Wang XZ. Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: Albumin to fibrinogen ratio and C-reactive protein to albumin ratio. Int Immunopharmacol. 2018;62:293-298. doi: 10.1016/j.intimp.2018.07.007.
Qin G, Tu J, Liu L, Luo L, Wu J, Tao L, Zhang C, Geng X, Chen X, Ai X, Shen B, Pan W. Serum Albumin and C-Reactive Protein/Albumin Ratio Are Useful Biomarkers of Crohn's Disease Activity. Med Sci Monit. 2016;22:4393-4400. doi: 10.12659/msm.897460.
Çelikkol A, Güzel EÇ, Doğan M, Erdal B, Yilmaz A. C-Reactive Protein-to-Albumin Ratio as a Prognostic Inflammatory Marker in COVID-19. J Lab Physicians. 2022;14(1):74-83. doi: 10.1055/s-0041-1741439.
Park JE, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Park MS, Kim YS, Chang J, Leem AY. The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients. J Clin Med. 2018;7(10):333. doi: 10.3390/jcm7100333.
Kaplan H, Cengiz G, Şaş S, Eldemir YÖ. Is the C-reactive protein-to-albumin ratio the most remarkable simple inflammatory marker showing active disease in patients with axial spondyloarthritis, psoriatic arthritis, and rheumatoid arthritis? Clin Rheumatol. 2023;42(11):2959-2969. doi: 10.1007/s10067-023-06703-8.
Tanrıkulu AB, Kaya H, Çatak Z. Elevated C-reactive protein/albumin ratio in patients with methamphetamine use disorder. Int J Psychiatry Clin Pract. 2023;27(4):351-358. doi: 10.1080/13651501.2023.2237557.
Di QS, Xu T, Song Y, Zuo ZG, Cao FJ, Yu XJ, Tang JY, Zhang W, Li C, Wan GX, Cai XJ. High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma. Dose Response. 2020;18(2):1559325820917824. doi: 10.1177/1559325820917824.
Fan Z, Fan K, Gong Y, Huang Q, Yang C, Cheng H, Jin K, Ni Q, Yu X, Luo G, Liu C. The CRP/Albumin Ratio Predicts Survival And Monitors Chemotherapeutic Effectiveness In Patients With Advanced Pancreatic Cancer. Cancer Manag Res. 2019;11:8781-8788. doi: 10.2147/CMAR.S211363.
Gwak CH, Suh J, Lim B, Song C, You D, Jeong IG, Hong JH, Hong B, Ahn H. Preoperative C-reactive protein to albumin ratio as a novel prognostic biomarker for the oncological outcomes of radical nephroureterectomy. Urol Oncol. 2024;42(2):30.e17-30.e23. doi: 10.1016/j.urolonc.2023.10.011.
Alkurt EG, Durak D, Turhan VB, Sahiner IT. Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients. Cureus. 2022;14(4):e23972. doi: 10.7759/cureus.23972.
Bayram E, Kidi MM, Camadan YA, Biter S, Yaslikaya S, Toyran T, Mete B, Kara IO, Sahin B. Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios? J Clin Med. 2024;13(10):2984. doi: 10.3390/jcm13102984.
Zhou X, Fu S, Wu Y, Guo Z, Dian W, Sun H, Liao Y. C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram. Sci Rep. 2023;13(1):15309. doi: 10.1038/s41598-023-42601-4.
Jia-Min Z, Wei D, Ye L, Xiang-Tao P. Correlation between C-reactive protein/albumin ratio and prognosis in patients with lung adenocarcinoma. J Int Med Res. 2022;50(6):3000605221105372. doi: 10.1177/03000605221105372.
Gao M, Zhang C, Gao L, Sun S, Song L, Liu S. Association between C-reactive protein-albumin ratio and overall survival in Parkinson's disease using publicly available data: A retrospective cohort study. Heliyon. 2023;9(2):e12671. doi: 10.1016/j.heliyon.2022.e12671.
Tillett WS, Francis T. Serologıcal reactıons ın pneumonıa wıth a non-proteın somatıc fractıon of pneumococcus. J Exp Med. 1930;52(4):561-71. doi: 10.1084/jem.52.4.561.
Clyne B, Olshaker JS. The C-reactive protein. J Emerg Med. 1999;17(6):1019-25. doi: 10.1016/s0736-4679(99)00135-3.
Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. doi: 10.3389/fimmu.2018.00754.
Calabró P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003;108(16):1930-2. doi: 10.1161/01.CIR.0000096055.62724.
Devaraj S, Singh U, Jialal I. The evolving role of C-reactive protein in atherothrombosis. Clin Chem. 2009;55(2):229-38. doi: 10.1373/clinchem.2008.108886.
Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102(18):2165-8. doi: 10.1161/01.cir.102.18.2165.
Calabro P, Chang DW, Willerson JT, Yeh ET. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol. 2005;46(6):1112-3. doi: 10.1016/j.jacc.2005.06.017.
Kaplan MH, Volanakis JE. Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol. 1974 Jun;112(6):2135-47.
Healy B, Freedman A. Infections. BMJ. 2006;332(7545):838-41. doi: 10.1136/bmj.332.7545.838.
Kingsley A, Jones V. Diagnosing wound infection: the use of C-reactive protein. Wounds Uk, 2008; 4(4): 32-46.
Fang P, Shi M, Yu M, Guo L, Bo P, Zhang Z. Endogenous peptides as risk markers to assess the development of insulin resistance. Peptides. 2014;51:9-14. doi: 10.1016/j.peptides.2013.10.025.
Ding Z, Wei Y, Peng J, Wang S, Chen G, Sun J. The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging. Biomedicines. 2023;11(10):2711. doi: 10.3390/biomedicines11102711.
Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis. 2009;206(1):61-8. doi: 10.1016/j.atherosclerosis.2009.02.002.
Hage FG, Szalai AJ. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol. 2007;50(12):1115-22. doi: 10.1016/j.jacc.2007.06.012.
Osman R, L'Allier PL, Elgharib N, Tardif JC. Critical appraisal of C-reactive protein throughout the spectrum of cardiovascular disease. Vasc Health Risk Manag. 2006;2(3):221-37. doi: 10.2147/vhrm.2006.2.3.221.
Enocsson H, Karlsson J, Li HY, Wu Y, Kushner I, Wetterö J, Sjöwall C. The Complex Role of C-Reactive Protein in Systemic Lupus Erythematosus. J Clin Med. 2021;10(24):5837. doi: 10.3390/jcm10245837.
Atas DB, Sahin GK, Şengül Ş, Kaya B, Paydaş S, Alibaz-Oner F, Direskeneli H, Tuglular S, Asicioglu E. C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis. Mediterr J Rheumatol. 2023;34(1):71-77. doi: 10.31138/mjr.34.1.71.
Largman-Chalamish M, Wasserman A, Silberman A, Levinson T, Ritter O, Berliner S, Zeltser D, Shapira I, Rogowski O, Shenhar-Tsarfaty S. Differentiating between bacterial and viral infections by estimated CRP velocity. PLoS One. 2022;17(12):e0277401. doi: 10.1371/journal.pone.0277401.
Cao Y, Yao X. Acute albumin administration as therapy for intracerebral hemorrhage: A literature review. Heliyon. 2023;10(1):e23946. doi: 10.1016/j.heliyon.2023.e23946.
Spada A, Emami J, Tuszynski JA, Lavasanifar A. The Uniqueness of Albumin as a Carrier in Nanodrug Delivery. Mol Pharm. 2021;18(5):1862-1894. doi: 10.1021/acs.molpharmaceut.1c00046.
Chien SC, Chen CY, Lin CF, Yeh HI. Critical appraisal of the role of serum albumin in cardiovascular disease. Biomark Res. 2017;5:31. doi: 10.1186/s40364-017-0111-x.
Keller U. Nutritional Laboratory Markers in Malnutrition. J Clin Med. 2019;8(6):775. doi: 10.3390/jcm8060775.
Ohwada H, Nakayama T, Kanaya Y, Tanaka Y. Serum albumin levels and their correlates among individuals with motor disorders at five institutions in Japan. Nutr Res Pract. 2017;11(1):57-63. doi: 10.4162/nrp.2017.11.1.57.
Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients. Am J Med. 2017;130(12):1465.e11-1465.e19. doi: 10.1016/j.amjmed.2017.07.020.
Kaplan M, Ates I, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, Coskun O, Kayacetin E. Predictive value of C-reactive protein/albumin ratio in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2017;16(4):424-430. doi: 10.1016/S1499-3872(17)60007-9.
Öçal R, Akın Öçal FC, Güllüev M, Alataş N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86(2):180-184. doi: 10.1016/j.bjorl.2018.10.007.
Cacciola G, Mancino F, Holzer LA, De Meo F, De Martino I, Bruschetta A, Risitano S, Sabatini L, Cavaliere P. Predictive Value of the C-Reactive Protein to Albumin Ratio in 30-Day Mortality after Hip Fracture in Elderly Population: A Retrospective Observational Cohort Study. J Clin Med. 2023;12(13):4544. doi: 10.3390/jcm12134544.
Liu Y, Gao Y, Liang B, Liang Z. The prognostic value of C-reactive protein to albumin ratio in patients with sepsis: a systematic review and meta-analysis. Aging Male. 2023;26(1):2261540. doi: 10.1080/13685538.2023.2261540.
Yang X, Yang X, Yang J, Wen X, Wu S, Cui L. High levels of high-sensitivity C reactive protein to albumin ratio can increase the risk of cardiovascular disease. J Epidemiol Community Health. 2023;77(11):721-727. doi: 10.1136/jech-2023-220760.
He D, Yang Y, Yang Y, Tang X, Huang K. Prognostic significance of preoperative C-reactive protein to albumin ratio in non-small cell lung cancer patients: A meta-analysis. Front Surg. 2023;9:1056795. doi: 10.3389/fsurg.2022.1056795.
Chen YH, Wang L, Feng SY, Cai WM, Chen XF, Huang ZM. The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease. Gastroenterol Res Pract. 2020;2020:3467419. doi: 10.1155/2020/3467419.
Yang WM, Zhang WH, Ying HQ, Xu YM, Zhang J, Min QH, Huang B, Lin J, Chen JJ, Wang XZ. Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: Albumin to fibrinogen ratio and C-reactive protein to albumin ratio. Int Immunopharmacol. 2018;62:293-298. doi: 10.1016/j.intimp.2018.07.007.
Qin G, Tu J, Liu L, Luo L, Wu J, Tao L, Zhang C, Geng X, Chen X, Ai X, Shen B, Pan W. Serum Albumin and C-Reactive Protein/Albumin Ratio Are Useful Biomarkers of Crohn's Disease Activity. Med Sci Monit. 2016;22:4393-4400. doi: 10.12659/msm.897460.
Çelikkol A, Güzel EÇ, Doğan M, Erdal B, Yilmaz A. C-Reactive Protein-to-Albumin Ratio as a Prognostic Inflammatory Marker in COVID-19. J Lab Physicians. 2022;14(1):74-83. doi: 10.1055/s-0041-1741439.
Park JE, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Park MS, Kim YS, Chang J, Leem AY. The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients. J Clin Med. 2018;7(10):333. doi: 10.3390/jcm7100333.
Kaplan H, Cengiz G, Şaş S, Eldemir YÖ. Is the C-reactive protein-to-albumin ratio the most remarkable simple inflammatory marker showing active disease in patients with axial spondyloarthritis, psoriatic arthritis, and rheumatoid arthritis? Clin Rheumatol. 2023;42(11):2959-2969. doi: 10.1007/s10067-023-06703-8.
Tanrıkulu AB, Kaya H, Çatak Z. Elevated C-reactive protein/albumin ratio in patients with methamphetamine use disorder. Int J Psychiatry Clin Pract. 2023;27(4):351-358. doi: 10.1080/13651501.2023.2237557.
Di QS, Xu T, Song Y, Zuo ZG, Cao FJ, Yu XJ, Tang JY, Zhang W, Li C, Wan GX, Cai XJ. High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma. Dose Response. 2020;18(2):1559325820917824. doi: 10.1177/1559325820917824.
Fan Z, Fan K, Gong Y, Huang Q, Yang C, Cheng H, Jin K, Ni Q, Yu X, Luo G, Liu C. The CRP/Albumin Ratio Predicts Survival And Monitors Chemotherapeutic Effectiveness In Patients With Advanced Pancreatic Cancer. Cancer Manag Res. 2019;11:8781-8788. doi: 10.2147/CMAR.S211363.
Gwak CH, Suh J, Lim B, Song C, You D, Jeong IG, Hong JH, Hong B, Ahn H. Preoperative C-reactive protein to albumin ratio as a novel prognostic biomarker for the oncological outcomes of radical nephroureterectomy. Urol Oncol. 2024;42(2):30.e17-30.e23. doi: 10.1016/j.urolonc.2023.10.011.
Alkurt EG, Durak D, Turhan VB, Sahiner IT. Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients. Cureus. 2022;14(4):e23972. doi: 10.7759/cureus.23972.
Bayram E, Kidi MM, Camadan YA, Biter S, Yaslikaya S, Toyran T, Mete B, Kara IO, Sahin B. Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios? J Clin Med. 2024;13(10):2984. doi: 10.3390/jcm13102984.
Zhou X, Fu S, Wu Y, Guo Z, Dian W, Sun H, Liao Y. C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram. Sci Rep. 2023;13(1):15309. doi: 10.1038/s41598-023-42601-4.
Pages
33-42
Published
November 7, 2024
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