Mineral Takviyesi
Synopsis
Bitkisel ilaçlar ve besin takviyeleri hastalar tarafından yaygın olarak kullanılmaktadır. Gıda takviyeleri ve alternatif tedaviler, kanser teşhisi konmuş hastaların tahminen yüzde 60 ila 80'i tarafından kullanılmaktadır ve tüm kanser tedavi süreci boyunca kullandıkları tespit edilmiştir. Kanser hastalarında besin takviyelerinin kullanımı, cerrahi, sistemik tedavi ve radyasyon tedavisi de dahil olmak üzere tedavinin tüm aşamalarında risk oluşturabilir.
Mineral eksiklikleri ve kanser arasında bazı ilişkiler bulunmuş olsa da, daha önemli kanıtlara ihtiyaç vardır. Mineral takviyelerindeki her mineralin kendi toksisite ve yan etki potansiyeli olabilir.
Bu nedenle, tüm diyet takviyelerinin bir tıp uzmanı tarafından onaylanması ve öngörülen dozlarda alınması önemlidir.
Herbal medicines and nutritional supplements are commonly used by patients. Food supplements and alternative therapies are utilized by an estimated 60 to 80 percent of patients who have been diagnosed with cancer, and they have been found to be used throughout the entire cancer treatment process. The use of dietary supplements in cancer patients may present risks at all stages of treatment, including surgery, systemic therapy, and radiation therapy.
While there have been some associations between mineral deficiencies and cancer, more substantial evidence is required. Each mineral in mineral supplements may have its own potential for toxicity and side effects.
Therefore, it is important for all dietary supplements to be approved by a medical professional and to be taken in the prescribed doses.
References
Falci L, Shi Z, Greenlee H. Multiple Chronic Conditions and Use of Complementary and Alternative Medicine Among US Adults: Results From the 2012 National Health Interview Survey. Prev Chronic Dis. 2016 May 5;13:E61. doi: 10.5888/pcd13.150501.
Richardson MA, Sanders T, Palmer JL, et al. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000 Jul;18(13):2505-14. doi: 10.1200/JCO.2000.18.13.2505.
Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001 Jul 11;286(2):208-16. doi: 10.1001/jama.286.2.208.
Shord SS, Shah K, Lukose A. Drug-botanical interactions: a review of the laboratory, animal, and human data for 8 common botanicals. Integr Cancer Ther. 2009 Sep;8(3):208-27. doi: 10.1177/1534735409340900.
Yasueda A, Urushima H, Ito T. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Integr Cancer Ther. 2016 Mar;15(1):17-39. doi: 10.1177/1534735415610427.
Spallholz JE. On the nature of selenium toxicity and carcinostatic activity. Free Radic Biol Med. 1994 Jul;17(1):45-64. doi: 10.1016/0891-5849(94)90007-8.
Schrauzer GN, Surai PF (2009) Selenium in human and animal nutrition: resolved and unresolved issues. Crit Rev Biotechnol 29: 2–9.
Fritz H, Kennedy D, Fergusson D, Fernandes R, et al. (2011) Selenium and Lung Cancer: A Systematic Review and Meta Analysis. PLOS ONE 6(11): e26259. https://doi.org/10.1371/journal.pone.0026259
Vinceti M, Filippini T, Del Giovane C, et al.. Selenium for preventing cancer. Cochrane Database Syst Rev. 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4.
Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. 2007 Aug 21;147(4):217-23. doi: 10.7326/0003-4819-147-4-200708210-00175.
Muecke R, Schomburg L, Glatzel M, et al. German Working Group Trace Elements and Electrolytes in Oncology-AKTE. Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):828-35. doi: 10.1016/j.ijrobp.2009.08.013.
Puspitasari IM, Abdulah R, Yamazaki C, et al. Updates on clinical studies of selenium supplementation in radiotherapy. Radiat Oncol. 2014 May 29;9:125. doi: 10.1186/1748-717X-9-125.
Lobb, R.J., Jacobson, G.M., Cursons, R.T., et al. The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells. Int. J. Mol. Sci. 2018, 19, 3167. https://doi.org/10.3390/ijms19103167
Huebner, Jutta, et al. "Online survey of patients with breast cancer on complementary and alternative medicine." Breast Care 9.1 (2014): 60-63.
DeGeorge KC, Ring DJ, Dalrymple SN. Treatment of the Common Cold. Am Fam Physician. 2019 Sep 1;100(5):281-289. PMID: 31478634.
Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials. Clin Respir J. 2018 Mar;12(3):857-864. doi: 10.1111/crj.12646.
Tian X, Liu XL, Pi YP, et al. Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials. Front Oncol. 2018 Nov 19;8:484. doi: 10.3389/fonc.2018.00484.
Hoppe C, Kutschan S, Dörfler J, et al.. Zinc as a complementary treatment for cancer patients: a systematic review. Clin Exp Med. 2021 May;21(2):297-313. doi: 10.1007/s10238-020-00677-6.
Yildiz A, Kaya Y, Tanriverdi O. Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention. J Cancer Prev. 2019 Sep;24(3):146-154. doi: 10.15430/JCP.2019.24.3.146.
Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. Drug Saf 1995;12:314-33.
Penttilä O, Hurme H, Neuvonen PJ. Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol. 1975;9:131-4 54.
Hashimoto Y, Matsumoto T, Kojima A, et al. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat. 2001;8(5):367-71
Ponka P. Cellular iron metabolism. Kidney Int. 1999;55:2–11.
Ludwig H, Müldür E, Endler G, et al. Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol. 2013;24:1886–92.
Ludwig H, Müldür E, Endler G, et al. High prevalence of iron deficiency across different tumors correlates with anemia, increases during cancer treatment and is associated with poor performance status. Haematologica. 2011;96(Suppl 2):409.
Eckard J, Dai J, Wu J, et al.. Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis. Cancer Cell Int. 2010 Aug 19;10:28. doi: 10.1186/1475-2867-10-28.
Ludwig, H., Evstatiev, R., Kornek, G. et al. Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr 127, 907–919 (2015). https://doi.org/10.1007/s00508-015-0842-3
Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013 May;13(5):342-55. doi: 10.1038/nrc3495.
Wurzelmann, John I., et al. "Iron intake and the risk of colorectal cancer." Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 5.7 (1996): 503-507.
Delphine Denoyer, Shashank Masaldan, Sharon La Fontaine, et al. Targeting copper in cancer therapy: ‘Copper That Cancer’, Metallomics, Volume 7, Issue 11, November 2015, Pages 1459–1476, https://doi.org/10.1039/c5mt00149h
Daniela Almeida da Silva, Anastasia De Luca, Rosanna Squitti, et al. Copper in tumors and the use of copper-based compounds in cancer treatment, Journal of Inorganic Biochemistry, Volume 226,2022, 111634, ISSN 0162-0134, https://doi.org/10.1016/j.jinorgbio.2021.111634.
Helen H.W. Chen, Macus Tien Kuoo Platinum Drug Resistance with Copper-lowering Agents, Anticancer Research Oct 2013, 33 (10) 4157-4161;
Blaszczyk U, Duda-Chodak A (2013) Magnesium: its role in nutrition and carcinogenesis. Rocz Panstw Zakl Hig 64(3):165–171
Anastassopoulou J, Theophanides T (2002) Magnesium-DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals. Crit Rev Oncol Hematol 42(1):79–91.
Wolf FI, Cittadini ARM, Maier JAM (2009) Magnesium and tumors: ally or foe? Cancer Treat Rev 35(4):378–382. https://doi.org/10.1016/j.ctrv.2009.01.003
J. Anastassopoulou, T. Theophanides, Magnesium–DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals, Critical Reviews in Oncology/Hematology, Volume 42, Issue 1, 2002, Pages 79-91, https://doi.org/10.1016/S1040-8428(02)00006-9.
Cittadini, A., et al. "Magnesium in normal and neoplastic cell proliferation: state of the art on in vitro data." Magnesium Research 4.1 (1991): 23-33.
Hadfield, M. Gary, et al. "Human brain tumors and exposure to metal and non-metal elements: a case-control study." Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 17.1 (1998): 1-9.
Atsmon, J., Dolev, E. Drug-Induced Hypomagnesaemia. Drug-Safety 28, 763–788 (2005). https://doi.org/10.2165/00002018-200528090-00003
Patel R, Savage A. Symptomatic hypomagnesemia associated with gentamicin therapy. Nephron 1997; 23: 50–2
Willox, J., McAllister, E., Sangster, G. et al. Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: A randomised trial. Br J Cancer 54, 19–23 (1986). https://doi.org/10.1038/bjc.1986.147
Federica I. Wolf, Achille R.M. Cittadini, et al., Magnesium and tumors: Ally or foe?, Cancer Treatment Reviews,Volume 35, Issue 4, 2009, Pages 378-382, ISSN 0305-7372, https://doi.org/10.1016/j.ctrv.2009.01.003.
Ashique S, Kumar S, Hussain A, et al.. A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer. J Health Popul Nutr. 2023 Jul 27;42(1):74. doi: 10.1186/s41043-023-00423-0.
Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 2005 May;35(5):290-304. doi: 10.1111/j.1365-2362.2005.01487.x. PMID: 15860041.
Newmark HL, Wargovich MJ, Bruce WR. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl Cancer Inst. 1984 Jun;72(6):1323-5. PMID: 6587152.
Lamprecht SA, Lipkin M. Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann N Y Acad Sci. 2001 Dec;952:73-87. doi: 10.1111/j.1749-6632.2001.tb02729.x. PMID: 11795445.
Flood A, Peters U, Chatterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of women. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):126-32. PMID: 15668485.
Wactawski-Wende, J, Kotchen, JM, Anderson, GL, et al. (2006) Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354, 684–696
Bristow SM, Bolland MJ, MacLennan GS, et al. Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials. British Journal of Nutrition. 2013;110(8):1384-1393. doi:10.1017/S0007114513001050
Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL. Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr. 2001 Oct;74(4):549-54. doi: 10.1093/ajcn/74.4.549. PMID: 11566656.
Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res. 1998 Feb 1;58(3):442-7. PMID: 9458087.
Baron JA, Beach M, Wallace K, Grau MV, Sandler RS, Mandel JS, Heber D, Greenberg ER. Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):586-9. doi: 10.1158/1055-9965.EPI-04-0319. PMID: 15767334.
Peterlik M, Grant WB, Cross HS. Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep;29(9):3687-98. PMID: 19667166.
Michelle Harvie. Nutritional Supplements and Cancer: Potential Benefits and Proven Harms. ASCO Educational Book 2014 :34, e478-e486
Anaforoğlu İ, Emral R. İyot Eksikliği Hastalıkları Ve Türkiye’deki Durum. Türkiye Endokrinoloji ve Metabolizma Derneği Tiroid Hastaliklari Tani Ve Tedavi Kılavuzu 2023 Sayfa 51. ISBN: 978-605-66410-3-9
Richardson MA, Sanders T, Palmer JL, et al. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000 Jul;18(13):2505-14. doi: 10.1200/JCO.2000.18.13.2505.
Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001 Jul 11;286(2):208-16. doi: 10.1001/jama.286.2.208.
Shord SS, Shah K, Lukose A. Drug-botanical interactions: a review of the laboratory, animal, and human data for 8 common botanicals. Integr Cancer Ther. 2009 Sep;8(3):208-27. doi: 10.1177/1534735409340900.
Yasueda A, Urushima H, Ito T. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Integr Cancer Ther. 2016 Mar;15(1):17-39. doi: 10.1177/1534735415610427.
Spallholz JE. On the nature of selenium toxicity and carcinostatic activity. Free Radic Biol Med. 1994 Jul;17(1):45-64. doi: 10.1016/0891-5849(94)90007-8.
Schrauzer GN, Surai PF (2009) Selenium in human and animal nutrition: resolved and unresolved issues. Crit Rev Biotechnol 29: 2–9.
Fritz H, Kennedy D, Fergusson D, Fernandes R, et al. (2011) Selenium and Lung Cancer: A Systematic Review and Meta Analysis. PLOS ONE 6(11): e26259. https://doi.org/10.1371/journal.pone.0026259
Vinceti M, Filippini T, Del Giovane C, et al.. Selenium for preventing cancer. Cochrane Database Syst Rev. 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4.
Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. 2007 Aug 21;147(4):217-23. doi: 10.7326/0003-4819-147-4-200708210-00175.
Muecke R, Schomburg L, Glatzel M, et al. German Working Group Trace Elements and Electrolytes in Oncology-AKTE. Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):828-35. doi: 10.1016/j.ijrobp.2009.08.013.
Puspitasari IM, Abdulah R, Yamazaki C, et al. Updates on clinical studies of selenium supplementation in radiotherapy. Radiat Oncol. 2014 May 29;9:125. doi: 10.1186/1748-717X-9-125.
Lobb, R.J., Jacobson, G.M., Cursons, R.T., et al. The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells. Int. J. Mol. Sci. 2018, 19, 3167. https://doi.org/10.3390/ijms19103167
Huebner, Jutta, et al. "Online survey of patients with breast cancer on complementary and alternative medicine." Breast Care 9.1 (2014): 60-63.
DeGeorge KC, Ring DJ, Dalrymple SN. Treatment of the Common Cold. Am Fam Physician. 2019 Sep 1;100(5):281-289. PMID: 31478634.
Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials. Clin Respir J. 2018 Mar;12(3):857-864. doi: 10.1111/crj.12646.
Tian X, Liu XL, Pi YP, et al. Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials. Front Oncol. 2018 Nov 19;8:484. doi: 10.3389/fonc.2018.00484.
Hoppe C, Kutschan S, Dörfler J, et al.. Zinc as a complementary treatment for cancer patients: a systematic review. Clin Exp Med. 2021 May;21(2):297-313. doi: 10.1007/s10238-020-00677-6.
Yildiz A, Kaya Y, Tanriverdi O. Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention. J Cancer Prev. 2019 Sep;24(3):146-154. doi: 10.15430/JCP.2019.24.3.146.
Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. Drug Saf 1995;12:314-33.
Penttilä O, Hurme H, Neuvonen PJ. Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol. 1975;9:131-4 54.
Hashimoto Y, Matsumoto T, Kojima A, et al. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat. 2001;8(5):367-71
Ponka P. Cellular iron metabolism. Kidney Int. 1999;55:2–11.
Ludwig H, Müldür E, Endler G, et al. Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol. 2013;24:1886–92.
Ludwig H, Müldür E, Endler G, et al. High prevalence of iron deficiency across different tumors correlates with anemia, increases during cancer treatment and is associated with poor performance status. Haematologica. 2011;96(Suppl 2):409.
Eckard J, Dai J, Wu J, et al.. Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis. Cancer Cell Int. 2010 Aug 19;10:28. doi: 10.1186/1475-2867-10-28.
Ludwig, H., Evstatiev, R., Kornek, G. et al. Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr 127, 907–919 (2015). https://doi.org/10.1007/s00508-015-0842-3
Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013 May;13(5):342-55. doi: 10.1038/nrc3495.
Wurzelmann, John I., et al. "Iron intake and the risk of colorectal cancer." Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 5.7 (1996): 503-507.
Delphine Denoyer, Shashank Masaldan, Sharon La Fontaine, et al. Targeting copper in cancer therapy: ‘Copper That Cancer’, Metallomics, Volume 7, Issue 11, November 2015, Pages 1459–1476, https://doi.org/10.1039/c5mt00149h
Daniela Almeida da Silva, Anastasia De Luca, Rosanna Squitti, et al. Copper in tumors and the use of copper-based compounds in cancer treatment, Journal of Inorganic Biochemistry, Volume 226,2022, 111634, ISSN 0162-0134, https://doi.org/10.1016/j.jinorgbio.2021.111634.
Helen H.W. Chen, Macus Tien Kuoo Platinum Drug Resistance with Copper-lowering Agents, Anticancer Research Oct 2013, 33 (10) 4157-4161;
Blaszczyk U, Duda-Chodak A (2013) Magnesium: its role in nutrition and carcinogenesis. Rocz Panstw Zakl Hig 64(3):165–171
Anastassopoulou J, Theophanides T (2002) Magnesium-DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals. Crit Rev Oncol Hematol 42(1):79–91.
Wolf FI, Cittadini ARM, Maier JAM (2009) Magnesium and tumors: ally or foe? Cancer Treat Rev 35(4):378–382. https://doi.org/10.1016/j.ctrv.2009.01.003
J. Anastassopoulou, T. Theophanides, Magnesium–DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals, Critical Reviews in Oncology/Hematology, Volume 42, Issue 1, 2002, Pages 79-91, https://doi.org/10.1016/S1040-8428(02)00006-9.
Cittadini, A., et al. "Magnesium in normal and neoplastic cell proliferation: state of the art on in vitro data." Magnesium Research 4.1 (1991): 23-33.
Hadfield, M. Gary, et al. "Human brain tumors and exposure to metal and non-metal elements: a case-control study." Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 17.1 (1998): 1-9.
Atsmon, J., Dolev, E. Drug-Induced Hypomagnesaemia. Drug-Safety 28, 763–788 (2005). https://doi.org/10.2165/00002018-200528090-00003
Patel R, Savage A. Symptomatic hypomagnesemia associated with gentamicin therapy. Nephron 1997; 23: 50–2
Willox, J., McAllister, E., Sangster, G. et al. Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: A randomised trial. Br J Cancer 54, 19–23 (1986). https://doi.org/10.1038/bjc.1986.147
Federica I. Wolf, Achille R.M. Cittadini, et al., Magnesium and tumors: Ally or foe?, Cancer Treatment Reviews,Volume 35, Issue 4, 2009, Pages 378-382, ISSN 0305-7372, https://doi.org/10.1016/j.ctrv.2009.01.003.
Ashique S, Kumar S, Hussain A, et al.. A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer. J Health Popul Nutr. 2023 Jul 27;42(1):74. doi: 10.1186/s41043-023-00423-0.
Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 2005 May;35(5):290-304. doi: 10.1111/j.1365-2362.2005.01487.x. PMID: 15860041.
Newmark HL, Wargovich MJ, Bruce WR. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl Cancer Inst. 1984 Jun;72(6):1323-5. PMID: 6587152.
Lamprecht SA, Lipkin M. Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann N Y Acad Sci. 2001 Dec;952:73-87. doi: 10.1111/j.1749-6632.2001.tb02729.x. PMID: 11795445.
Flood A, Peters U, Chatterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of women. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):126-32. PMID: 15668485.
Wactawski-Wende, J, Kotchen, JM, Anderson, GL, et al. (2006) Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354, 684–696
Bristow SM, Bolland MJ, MacLennan GS, et al. Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials. British Journal of Nutrition. 2013;110(8):1384-1393. doi:10.1017/S0007114513001050
Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL. Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr. 2001 Oct;74(4):549-54. doi: 10.1093/ajcn/74.4.549. PMID: 11566656.
Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res. 1998 Feb 1;58(3):442-7. PMID: 9458087.
Baron JA, Beach M, Wallace K, Grau MV, Sandler RS, Mandel JS, Heber D, Greenberg ER. Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):586-9. doi: 10.1158/1055-9965.EPI-04-0319. PMID: 15767334.
Peterlik M, Grant WB, Cross HS. Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep;29(9):3687-98. PMID: 19667166.
Michelle Harvie. Nutritional Supplements and Cancer: Potential Benefits and Proven Harms. ASCO Educational Book 2014 :34, e478-e486
Anaforoğlu İ, Emral R. İyot Eksikliği Hastalıkları Ve Türkiye’deki Durum. Türkiye Endokrinoloji ve Metabolizma Derneği Tiroid Hastaliklari Tani Ve Tedavi Kılavuzu 2023 Sayfa 51. ISBN: 978-605-66410-3-9
Pages
349-356
Published
March 11, 2024
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Elçiçek ÖF. Mineral Takviyesi. In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 349-56. Available from: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13938
