Bayır Turbu (Armoracia Rusticana)
Synopsis
Bitkiler tarih boyunca ve farklı kültürlerde tıbbi amaçlarla kullanılmıştır. Bu uygulamaya dair bilinen en eski kanıt Mısır yazıtlarından gelmektedir. Dünya Sağlık Örgütü'ne göre günümüzde yaklaşık 20.000 bitki türü tedavi amaçlı kullanılmaktadır. Türkiye, birçoğu endemik olmak üzere çok çeşitli bitki türlerinin bulunduğu bir bölgede yer almaktadır. Tahminlere göre, geleneksel olarak tıbbi amaçlarla kullanılan yaklaşık 140 bitki türü bulunmaktadır.
Bu bitkilerden biri, Cruciferae familyasından olan ve baharat olarak kullanılabilen faydalı biyolojik bileşikler içeren kökleri için değerli olan çok yıllık bir bitki olan yaban turpudur (Armoracia rusticana). Yaban turpunun antimikrobiyal, antifungal, anti-enflamatuar, antiviral ve anti-tümöral aktivite dahil olmak üzere çeşitli terapötik özelliklere sahip olduğu bulunmuştur. Çalışmalar mesane, kolon, akciğer, meme, yemek borusu ve mide kanserine karşı etkinliğini göstermiştir. Ayrıca, solunum ve idrar yolu enfeksiyonuna karşı koruyucu bir etkiye sahip olduğu gösterilmiştir.
Plants have been used for medicinal purposes throughout history and across cultures. The oldest known evidence of this practice comes from Egyptian inscriptions. According to the World Health Organization, approximately 20,000 plant species are used for therapeutic purposes today. Turkey is located in a region with a diverse range of plant species, including many that are endemic. According to estimates, there are around 140 plant species that are traditionally used for medicinal purposes.
One such plant is horseradish (Armoracia rusticana), a perennial plant from the Cruciferae family that is valued for its roots, which contain beneficial biological compounds that can be used as a spice. Horseradish has been found to possess various therapeutic properties, including antimicrobial, antifungal, anti-inflammatory, antiviral, and anti-tumoral activity. Studies have shown its effectiveness against bladder, colon, lung, breast, esophagus, and stomach cancer. Furthermore, it has been demonstrated to have a protective effect against respiratory and urinary tract infection.
References
Veitch N.C. Horseradish peroxidase: A modern view of a classic enzyme. Phytochemistry. 2004;65:249–259. doi: 10.1016/j.phytochem.2003.10.022.
Jiang Z.T., Li R., Yu J.C. Pungent components from thioglucosides in Armoracia rusticana grown in China, obtained by enzymatic hydrolysis. Food Technol. Biotechnol. 2006;44:41–45.
Jurikova T., Rop O., Mlcek J et al. Phenolic profile of edible honeysuckle berries (genus Lonicera.) and their biological effects. Molecules. 2012;17:61–79.
Smith A.T., Santama N., Dacey S., et al. Expression of a synthetic gene for horseradish peroxidase C in Escherichia coli and folding and activation of recombinant enzyme with Ca2+ and heme. J. Biol. Chem. 1990;265:13335–13343.
Li X., Kushad M.M. Purification and characterization of myrosinase from horseradish (Armoracia rusticana) roots. Plant Physiol. Biochem. 2005;43:503–511. doi: 10.1016/j.plaphy.2005.03.015.
Li X., Kushad M.M. Correlation of glucosinolates content to myrosinase activity in horseradish (Armoracia rusticana) J. Agric. Food Chem. 2004;52:6950–6955. doi: 10.1021/jf0401827.
Prockop D.J., Kivirikko K.I. Collagens: Molecular biology, diseases, and potentials for therapy. Ann. Rev. Biochem. 1995;64:403–434. doi: 10.1146/annurev.bi.64.070195.002155.
Padayatty S.J., Katz A., Wang Y., et al. ., Lee J.H., Chen S., Corpe C., Dutta A., Dutta S.K., et al. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J. Am. Coll. Nutr. 2003;22:18–35. doi: 10.1080/07315724.2003.10719272.
Drouin G., Godin J.R., Pagé B. The genetics of vitamin C loss in vertebrates. Curr. Genomics. 2011;12:371–378. doi: 10.2174/138920211796429736.
Fursa N.S., Litvinenko V.I., Krivenchuk P.E. Flavonoids of Armoracia rusticana and Barbarea arcuata. Chem. Nat. Compd. 1969;5:270–271.
Harborne J.B., Baxter H. Chemical Dictionary of Economic Plants. John Wiley & Sons Ltd; New York, NY, USA: 2001. p. 114.
Cho E.J., Yokozawa T., Rhyu D.Y., et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. Am. J. Chin. Med. 2003;31:907–917. doi: 10.1142/S0192415X03001648.
Bhagwat S., Haytowitz D.B., Holden J.M. USDA Database for the Flavonoid Content of Selected Foods. Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center. [(accessed on 24 February 2014)].
Cirimbei M.R., Dinică R., Gitina L., Vizireanu C. Study on herbal action of horseradish (Armoracia rusticana) J. Agroaliment. Proc. Technol. 2013;19:111–115.
Courter J.W., Rhodes A.M. Historical notes on horseradish. Econ. Bot. 1969;23:156–164. doi: 10.1007/BF02860621.
Segneanu A.-E., Cepan M., Bobica A., Stanusoiu I., Dragomir I.C., Parau A., Grozescu I. Chemical Screening of Metabolites Profile from Romanian Tuber spp. Plants. 2021;10:540. doi: 10.3390/plants10030540.
Rivelli A.R., De Maria S. Exploring the physiological and agronomic response of Armoracia rusticana grown in rainfed Mediterranean conditions. Ital. J. Agron. 2019;14:133–141. doi: 10.4081/ija.2019.1445.
Kroener E.-M., Buettner A. Sensory-Analytical Comparison of the Aroma of Different Horseradish Varieties (Armoracia rusticana) Front. Chem. 2018;6:149. doi: 10.3389/fchem.2018.00149.
Papp N., Gonda S., Kiss-Szikszai A., Plaszkó T., Lőrincz P., Vasas G. Ethnobotanical and ethnopharmacological data of Armoracia rusticana P. Gaertner, B. Meyer et Scherb. in Hungary and Romania: A case study. Genet. Resour. Crop Evol. 2018;65:1893–1905. doi: 10.1007/s10722-018-0663-0.
Anam Y., Qayyum F., Ahmad Mugha et al. Phytochemical and biological investigation of Armoracia rusticana. Int. J. Pharm. Integr. Health Sci. 2020;1:58.
Agneta R., Möllers C., Rivelli A.R. Horseradish (Armoracia rusticana), a neglected medical and condiment species with a relevant glucosinolate profile: A review. Genet. Resour. Crop. Evol. 2013;60:1923–1943. doi: 10.1007/s10722-013-0010-4.
Nguyen N.M., Gonda S., Vasas G. A Review on the Phytochemical Composition and Potential Medicinal Uses of Horseradish (Armoracia rusticana) Root. Food Rev. Int. 2013;29:261–275. doi: 10.1080/87559129.2013.790047.
Zhao Q., Luan X., Zheng M., Tian X.-H., et al. Synergistic mechanisms of constituents in herbal extracts during intestinal absorption: Focus on natural occurring nanoparticles. Pharmaceutics. 2020;12:128. doi: 10.3390/pharmaceutics12020128.
Hussein R.A., El-Anssary A.A. Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants. In: Builders P.F., editor. Herbal Medicine. IntechOpen; London, UK: 2019.
Nath R., Roy R., Barai G., Bairagi S., et al. Modern developments of nano based grug delivery system by combined with phytochemicals-presenting new aspects. Int. J. Sci. Res. Sci. Technol. 2021;8:107–129.
Barba F.J., Nikmaram N., Roohinejad S., et al. Bioavailability of Glucosinolates and Their Breakdown Products: Impact of Processing. Front. Nutr. 2016;3:24. doi: 10.3389/fnut.2016.00024.
Pal S.K., Shukla Y. Herbal medicine: Current status and the future. Asian Pac. J. Cancer Prev. 2003;4:281–288.
Sánchez M., González-Burgos E., Iglesias I., et al. Current uses and knowledge of medicinal plants in the Autonomous Community of Madrid (Spain): A descriptive cross-sectional study. BMC Complement. Med. Ther. 2020;20:306. doi: 10.1186/s12906-020-03089-x.
Alam S., Sarker M.R., Afrin S., et al. Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions. Front. Pharmacol. 2021;12:671498. doi: 10.3389/fphar.2021.671498.
Okazaki K, Yamagishi M, Son HY, et al. 2002. Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Nutr. Cancer 42: 211–216.
Chung FL, Conaway CC, Rao CV, et al. 2000. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21: 2287–2291.
Wattenberg LW. 1977. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst. 58: 395–398.
Morse MA, Eklind KI, Hecht SS, et al. 1991. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 51: 1846–1850.
Nishikawa A, Furukawa F, Uneyama C, et al. 1996. Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in Nnitrosobis(2-oxopropyl)amine-treated hamsters. Carcinogenesis 17: 1381–1384.
Bogaards JJ, van Ommen B, Falke HE, et al. 1990. Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics. Food Chem. Toxicol. 28: 81–88.
Guo Z, Smith TJ, Wang E, et al. 1993. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis 14: 1167–1173.
Nishikawa A, Lee IS, Uneyama C, et al. 1997. Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters. Jpn. J. Cancer Res. 88: 1137–1142.
Dingley KH, Ubick EA, Chiarappa-Zucca ML, et al. 2003. Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr. Cancer 46: 212–221.
Munday R, Munday CM. 2004. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.J. Agric. Food Chem. 52: 1867–1871.
London SJ, Yuan JM, Chung FL, et al. 2000. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a p
Seow A, Yuan JM, Sun CL, Van Den Berg D, Lee HP, Yu MC. 2002. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23: 2055–2061.
Cohen JH, Kristal AR, Stanford JL. 2000. Fruit and vegetable intakes and prostate cancer risk. J. Natl. Cancer Inst. 92: 61–68.
Tang L, Zirpoli GR, Guru K, Moysich KB, et al. 2008. Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol. Biomark. Prev. 17: 938–944.
Yamaji T, Inoue M, Sasazuki S, et al. Japan Public Health Center-based Prospective Study G. 2008. Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. Int. J. Cancer 123: 1935–1940.
Suzuki I, Cho YM, Hirata T, et al. 2016a. 4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats. J. Toxicol. Pathol. 29: 237–246
J.D. Clarke, R.H. Dashwood, E. Ho, Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269 (2008) 291-304 doi.org/10.1016/j.canlet.2008.04.018
K.L. Cheung, A.N. Kong, Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 12 (2010) 87-97 doi.org/10.1208/s12248-009-9162-8.
C. Fimognari, M. Lenzi, D. Sciuscio, et al. Cell-cycle specificity of sulforaphanemediated apoptosis in Jurkat T-leukemia cells. In Vivo 21 (2007) 377-380.
A.V. Singh, D. Xiao, K.L. Lew, R. Dhir, et al. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 25 (2004) 83-90 doi.org/10.1093/carcin/bgg178.
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Interdisziplin¨ are S3 Leitlinie: Epidemiologie, Diagnostik, Theapie, Plr¨ abvention und Mangement unkomplizierter, bakterieller, ambulant erworbener Harnwegsinfektionen bei erwachsenen Patienten, 2017.
C. Kühn, F. Kupke, S. Baldermann, et al. Diverse excretion pathways of benzyl Glucosinolate in humans after consumption of Nasturtium (Tropaeolum majus L.)-a pilot study, Mol. Nutr. Food Res. 62 (2018), e1800588.
E. Lamy, C. Scholtes, C. Herz, V. Mersch-Sundermann, Pharmacokinetics and pharmacodynamics of isothiocyanates, Drug Metab. Rev. 43 (2011) 387–407.
A. Borges, A.C. Abreu, C. Ferreira, M.J. et al. ˜Antibacterial activity and mode of action of selected glucosinolate hydrolysis products against bacterial pathogens, J. Food Sci. Technol. 52 (2015) 4737–4748
D. Nowicki, O. Rodzik, A. Herman-Antosiewicz, et al. Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action, Sci. Rep. 6 (2016) 22263
K.F. Tierens, B.P. Thomma, M. Brouwer, et al. Broekaert, Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens, Plant Physiol. 125 (2001) 1688–1699.
J.W. Fahey, X. Haristoy, P.M. Dolan, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzoapyreneinduced stomach tumors, Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 7610–7615
N.L. Johansson, C.S. Pavia, J.W. Chiao, Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables, Planta Med. 74 (2008) 747–750
M.G. Kim, H.S. Lee, Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria, J. Food Sci. 74 (2009) M467–M471
T. Matthes, K. Schmidt, Uber die carcinokolytische Wirkung der Cochlearia armoracia beim Ehrlichschen M¨ ause-Ascites-Carcinom, dem Jensen-Sarkom der Ratte und beim Hautkrebs des Menschen. Arztliche, Forschung 9 (1955) I/358-63.
J. Walther, Behandlung von Erkrankungen des Respirationstraktes mit einem Wirkstoffauszug aus Cochlearia armoracia (Meerrettich), Die Medizinische 4 (1959) 78–79.
S. Hontela, J. Pokorny, Our experiences with Rasapen in gynecological practice, Deutsches Medizinisches J. 13 (1962) 356–357.
North Carolina Plant Toolbox. Armoracia rusticana (horseradish, red cole) | NC State Extension. 2022.
Government of Canada. Monograph: Horseradish. Health Canada. 2018.
Jiang Z.T., Li R., Yu J.C. Pungent components from thioglucosides in Armoracia rusticana grown in China, obtained by enzymatic hydrolysis. Food Technol. Biotechnol. 2006;44:41–45.
Jurikova T., Rop O., Mlcek J et al. Phenolic profile of edible honeysuckle berries (genus Lonicera.) and their biological effects. Molecules. 2012;17:61–79.
Smith A.T., Santama N., Dacey S., et al. Expression of a synthetic gene for horseradish peroxidase C in Escherichia coli and folding and activation of recombinant enzyme with Ca2+ and heme. J. Biol. Chem. 1990;265:13335–13343.
Li X., Kushad M.M. Purification and characterization of myrosinase from horseradish (Armoracia rusticana) roots. Plant Physiol. Biochem. 2005;43:503–511. doi: 10.1016/j.plaphy.2005.03.015.
Li X., Kushad M.M. Correlation of glucosinolates content to myrosinase activity in horseradish (Armoracia rusticana) J. Agric. Food Chem. 2004;52:6950–6955. doi: 10.1021/jf0401827.
Prockop D.J., Kivirikko K.I. Collagens: Molecular biology, diseases, and potentials for therapy. Ann. Rev. Biochem. 1995;64:403–434. doi: 10.1146/annurev.bi.64.070195.002155.
Padayatty S.J., Katz A., Wang Y., et al. ., Lee J.H., Chen S., Corpe C., Dutta A., Dutta S.K., et al. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J. Am. Coll. Nutr. 2003;22:18–35. doi: 10.1080/07315724.2003.10719272.
Drouin G., Godin J.R., Pagé B. The genetics of vitamin C loss in vertebrates. Curr. Genomics. 2011;12:371–378. doi: 10.2174/138920211796429736.
Fursa N.S., Litvinenko V.I., Krivenchuk P.E. Flavonoids of Armoracia rusticana and Barbarea arcuata. Chem. Nat. Compd. 1969;5:270–271.
Harborne J.B., Baxter H. Chemical Dictionary of Economic Plants. John Wiley & Sons Ltd; New York, NY, USA: 2001. p. 114.
Cho E.J., Yokozawa T., Rhyu D.Y., et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. Am. J. Chin. Med. 2003;31:907–917. doi: 10.1142/S0192415X03001648.
Bhagwat S., Haytowitz D.B., Holden J.M. USDA Database for the Flavonoid Content of Selected Foods. Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center. [(accessed on 24 February 2014)].
Cirimbei M.R., Dinică R., Gitina L., Vizireanu C. Study on herbal action of horseradish (Armoracia rusticana) J. Agroaliment. Proc. Technol. 2013;19:111–115.
Courter J.W., Rhodes A.M. Historical notes on horseradish. Econ. Bot. 1969;23:156–164. doi: 10.1007/BF02860621.
Segneanu A.-E., Cepan M., Bobica A., Stanusoiu I., Dragomir I.C., Parau A., Grozescu I. Chemical Screening of Metabolites Profile from Romanian Tuber spp. Plants. 2021;10:540. doi: 10.3390/plants10030540.
Rivelli A.R., De Maria S. Exploring the physiological and agronomic response of Armoracia rusticana grown in rainfed Mediterranean conditions. Ital. J. Agron. 2019;14:133–141. doi: 10.4081/ija.2019.1445.
Kroener E.-M., Buettner A. Sensory-Analytical Comparison of the Aroma of Different Horseradish Varieties (Armoracia rusticana) Front. Chem. 2018;6:149. doi: 10.3389/fchem.2018.00149.
Papp N., Gonda S., Kiss-Szikszai A., Plaszkó T., Lőrincz P., Vasas G. Ethnobotanical and ethnopharmacological data of Armoracia rusticana P. Gaertner, B. Meyer et Scherb. in Hungary and Romania: A case study. Genet. Resour. Crop Evol. 2018;65:1893–1905. doi: 10.1007/s10722-018-0663-0.
Anam Y., Qayyum F., Ahmad Mugha et al. Phytochemical and biological investigation of Armoracia rusticana. Int. J. Pharm. Integr. Health Sci. 2020;1:58.
Agneta R., Möllers C., Rivelli A.R. Horseradish (Armoracia rusticana), a neglected medical and condiment species with a relevant glucosinolate profile: A review. Genet. Resour. Crop. Evol. 2013;60:1923–1943. doi: 10.1007/s10722-013-0010-4.
Nguyen N.M., Gonda S., Vasas G. A Review on the Phytochemical Composition and Potential Medicinal Uses of Horseradish (Armoracia rusticana) Root. Food Rev. Int. 2013;29:261–275. doi: 10.1080/87559129.2013.790047.
Zhao Q., Luan X., Zheng M., Tian X.-H., et al. Synergistic mechanisms of constituents in herbal extracts during intestinal absorption: Focus on natural occurring nanoparticles. Pharmaceutics. 2020;12:128. doi: 10.3390/pharmaceutics12020128.
Hussein R.A., El-Anssary A.A. Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants. In: Builders P.F., editor. Herbal Medicine. IntechOpen; London, UK: 2019.
Nath R., Roy R., Barai G., Bairagi S., et al. Modern developments of nano based grug delivery system by combined with phytochemicals-presenting new aspects. Int. J. Sci. Res. Sci. Technol. 2021;8:107–129.
Barba F.J., Nikmaram N., Roohinejad S., et al. Bioavailability of Glucosinolates and Their Breakdown Products: Impact of Processing. Front. Nutr. 2016;3:24. doi: 10.3389/fnut.2016.00024.
Pal S.K., Shukla Y. Herbal medicine: Current status and the future. Asian Pac. J. Cancer Prev. 2003;4:281–288.
Sánchez M., González-Burgos E., Iglesias I., et al. Current uses and knowledge of medicinal plants in the Autonomous Community of Madrid (Spain): A descriptive cross-sectional study. BMC Complement. Med. Ther. 2020;20:306. doi: 10.1186/s12906-020-03089-x.
Alam S., Sarker M.R., Afrin S., et al. Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions. Front. Pharmacol. 2021;12:671498. doi: 10.3389/fphar.2021.671498.
Okazaki K, Yamagishi M, Son HY, et al. 2002. Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Nutr. Cancer 42: 211–216.
Chung FL, Conaway CC, Rao CV, et al. 2000. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21: 2287–2291.
Wattenberg LW. 1977. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst. 58: 395–398.
Morse MA, Eklind KI, Hecht SS, et al. 1991. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 51: 1846–1850.
Nishikawa A, Furukawa F, Uneyama C, et al. 1996. Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in Nnitrosobis(2-oxopropyl)amine-treated hamsters. Carcinogenesis 17: 1381–1384.
Bogaards JJ, van Ommen B, Falke HE, et al. 1990. Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics. Food Chem. Toxicol. 28: 81–88.
Guo Z, Smith TJ, Wang E, et al. 1993. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis 14: 1167–1173.
Nishikawa A, Lee IS, Uneyama C, et al. 1997. Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters. Jpn. J. Cancer Res. 88: 1137–1142.
Dingley KH, Ubick EA, Chiarappa-Zucca ML, et al. 2003. Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr. Cancer 46: 212–221.
Munday R, Munday CM. 2004. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.J. Agric. Food Chem. 52: 1867–1871.
London SJ, Yuan JM, Chung FL, et al. 2000. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a p
Seow A, Yuan JM, Sun CL, Van Den Berg D, Lee HP, Yu MC. 2002. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23: 2055–2061.
Cohen JH, Kristal AR, Stanford JL. 2000. Fruit and vegetable intakes and prostate cancer risk. J. Natl. Cancer Inst. 92: 61–68.
Tang L, Zirpoli GR, Guru K, Moysich KB, et al. 2008. Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol. Biomark. Prev. 17: 938–944.
Yamaji T, Inoue M, Sasazuki S, et al. Japan Public Health Center-based Prospective Study G. 2008. Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. Int. J. Cancer 123: 1935–1940.
Suzuki I, Cho YM, Hirata T, et al. 2016a. 4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats. J. Toxicol. Pathol. 29: 237–246
J.D. Clarke, R.H. Dashwood, E. Ho, Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269 (2008) 291-304 doi.org/10.1016/j.canlet.2008.04.018
K.L. Cheung, A.N. Kong, Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 12 (2010) 87-97 doi.org/10.1208/s12248-009-9162-8.
C. Fimognari, M. Lenzi, D. Sciuscio, et al. Cell-cycle specificity of sulforaphanemediated apoptosis in Jurkat T-leukemia cells. In Vivo 21 (2007) 377-380.
A.V. Singh, D. Xiao, K.L. Lew, R. Dhir, et al. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 25 (2004) 83-90 doi.org/10.1093/carcin/bgg178.
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Interdisziplin¨ are S3 Leitlinie: Epidemiologie, Diagnostik, Theapie, Plr¨ abvention und Mangement unkomplizierter, bakterieller, ambulant erworbener Harnwegsinfektionen bei erwachsenen Patienten, 2017.
C. Kühn, F. Kupke, S. Baldermann, et al. Diverse excretion pathways of benzyl Glucosinolate in humans after consumption of Nasturtium (Tropaeolum majus L.)-a pilot study, Mol. Nutr. Food Res. 62 (2018), e1800588.
E. Lamy, C. Scholtes, C. Herz, V. Mersch-Sundermann, Pharmacokinetics and pharmacodynamics of isothiocyanates, Drug Metab. Rev. 43 (2011) 387–407.
A. Borges, A.C. Abreu, C. Ferreira, M.J. et al. ˜Antibacterial activity and mode of action of selected glucosinolate hydrolysis products against bacterial pathogens, J. Food Sci. Technol. 52 (2015) 4737–4748
D. Nowicki, O. Rodzik, A. Herman-Antosiewicz, et al. Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action, Sci. Rep. 6 (2016) 22263
K.F. Tierens, B.P. Thomma, M. Brouwer, et al. Broekaert, Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens, Plant Physiol. 125 (2001) 1688–1699.
J.W. Fahey, X. Haristoy, P.M. Dolan, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzoapyreneinduced stomach tumors, Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 7610–7615
N.L. Johansson, C.S. Pavia, J.W. Chiao, Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables, Planta Med. 74 (2008) 747–750
M.G. Kim, H.S. Lee, Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria, J. Food Sci. 74 (2009) M467–M471
T. Matthes, K. Schmidt, Uber die carcinokolytische Wirkung der Cochlearia armoracia beim Ehrlichschen M¨ ause-Ascites-Carcinom, dem Jensen-Sarkom der Ratte und beim Hautkrebs des Menschen. Arztliche, Forschung 9 (1955) I/358-63.
J. Walther, Behandlung von Erkrankungen des Respirationstraktes mit einem Wirkstoffauszug aus Cochlearia armoracia (Meerrettich), Die Medizinische 4 (1959) 78–79.
S. Hontela, J. Pokorny, Our experiences with Rasapen in gynecological practice, Deutsches Medizinisches J. 13 (1962) 356–357.
North Carolina Plant Toolbox. Armoracia rusticana (horseradish, red cole) | NC State Extension. 2022.
Government of Canada. Monograph: Horseradish. Health Canada. 2018.
Pages
275-280
Published
March 11, 2024
Copyright (c) 2024 Academician Publishing Book Portal
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Sezgin Y. Bayır Turbu (Armoracia Rusticana). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 275-80. Available from: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13928
