Oksidatif Stres, Sperm DNA Hasarı ve Tedavisi
Referanslar
Agarwal A, Prabhakaran SA, Sikka SC. Clinical relevance of oxidative stress in patients with male factor infertility: evidence-based analysis. AUA Update Series. 2007;26:1-12.
Hampl R, Drábková P, Kanďár R, Stěpán J. Impact of oxidative stress on male infertility.Ceska Gynekol. 2012;77:241-5.
Tvrdá E, Kňažická Z, Bárdos L, Massányi P, Lukáč N. Impact of oxidative stress on male fertility - a review. Acta Vet Hung. 2011;59:465-84.
Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996;48:835–50.
Gomez E, Buckingham DW, Brindle J. Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: correlation with biochemical markers of the cytoplasmic space, oxidative stress, and sperm function. J Androl. 1996;17:276.
Agarwal A, Saleh RA. Urol Clin N Am. 2002;29:817–27.
Henkel RR. Leukocytes and oxidative stress: dilemma for sperm function and male fertility.Asian J Androl. 2011;13:43-52.
Armstrong JS, Rajasekaran M, Chamulitrat W. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999;26:869.
Griveau JF and Le Lannou D: Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl. 1997;20:61.
Agarwal A, Nallella KP, Allamaneni SS. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online. 2004;8:616.
Hunter RH and Rodriguez-Martinez H. Capacitation of mammalian spermatozoa in vivo, with a specific focus on events in the fallopian tubes. Mol Reprod Dev. 2004; 67:243.
Zini A, de Lamirande E, Gagnon C. Low levels of nitric oxide promote human sperm capacitation in vitro. J Androl. 1996;16:424– 31.
Visconti PE, Moore GD, Bailey JL. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development. 1995;121:1139.
de Lamirande E, Leclerc P and Gagnon C. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 1997;3:175-8.
Kodama H, Kuribayashi Y and Gagnon C. Effect of sperm lipid peroxidation on fertilization. J Androl. 1996;17:151.
Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod. 1989;40:183–97.
Aitken RJ, Paterson M, Fisher H. Redox regulation of tyrosine phosphorylation in human spermatozoa is involved in the control of human sperm function. J Cell Sci 1995;108:2017–25.
Helbock HJ, Beckman KB, Shigenaga MK. DNA oxidation matters: the HPLCelectrochemical detection assay of 8-oxo-de- oxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci USA. 1998;95:288.
Tuğcu V, Gedikbaşi A, Mutlu B, Güner E, Uhri M, Andican G, Ozbek E, Taşçi AI. Increased testicular 8-hydroxy-2’-deoxyguanosine (8-OHdG) and inducible nitric oxide synthetase (iNOS) and nuclear factor κB (NF-κB) expressions in experimental rat varicocele. Arch Ital Urol Androl. 2010;82:148-53.
Simsek A, Ozbek E, Ilbey YO, Cekmen M, Somay A, Tasci AI. Potential role of p38- mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: an experimental study. Andrologia. 2011;15.
Piomboni P, Stendardi A, Gambera L, Tatone C, Coppola L, De Leo V, Focarelli R. Protein modification as oxidative stress marker in normal and pathological human seminal plasma.Redox Rep. 2012;7.
Agarwal A and Said TM. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update. 2003;9:331.
Sharma RK, Said T and Agarwal A. Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Asian J Androl. 2004;6:139.
Sakkas D, Urner F, Bizzaro D. Sperm nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo development. Hum Reprod 1998;13:11.
Sakkas D, Seli E, Bizzaro D. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reprod Biomed Online. 2003;7:428.
Alvarez JG, Sharma RK, Ollero M. Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay. Fertil Steril 2002;78:319.
Sikka SC. Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J Androl. 2004;25:5.
Kao S, Chao HT and Wei YH. Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm. Biol Reprod. 1995;52:729.
Diemer T, Allen JA, Hales KH et al. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 2003;144:2882.
Bennetts LE and Aitken RJ. A comparative study of oxidative DNA damage in mammalian spermatozoa. Mol Reprod Dev. 2005;71:77.
Agarwal A and Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503.
Yakes FM and Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 1997;94:514.
Halliwell B. Tell me about free radicals, doctor: a review. J R Soc Med. 1984;82:747–52.
Aitken RJ, Harkiss D, Buckingham D. Relationship between iron-catalyzed lipid peroxidation potential and human sperm function. J Reprod Ferti.l 1993;98:257–65.
Akyol O, Ozbek E, Uz E, Koçak I. Malondialdehyde level and total superoxide dismutase activity in seminal fluid from patients withvaricocele. Clin Exp Med. 2001;1:67-8.
Ozbek E, Cekmen M, Simsek A, Turkoz Y, Soylu A, Ilbey YO, Balbay MD. Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele. Int Urol Nephrol. 2008;40:679-83.
Wang X, Liu N. Sperm DNA oxidative damage in patients with idiopathic asthenozoospermia. 2012;37:100-5.
Agarwal A, Ikemoto I, Loughlin KR. Relationship of sperm parameters to levels of reactive oxygen species in semen specimens. J Urol. 1994;152:107–10.
Griveau JF, Dumont E, Renard B, et al. Reactive oxygen species, lipid peroxidation and enzymatic defense systems in human spermatozoa. J Reprod Fertil. 1995;103:17–26.
Ozbek E, Ilbey YY, Simşek A, Cekmen M, Balbay MD. Preoperative and postoperative seminal nitric oxide levels in patients with infertile varicocele. Arch Ital Urol Androl. 2009;81:248-50.
Ozbek E, Turkoz Y, Gokdeniz R, Davarci M, Ozugurlu F. Increased nitric oxide produc- tion in the spermatic vein of patients with varicocele. Eur Urol. 2000;37:172-5.
Twigg J, Irvine DS, Houston P, et al. IatrogenicDNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Mol Hum Reprod. 1998;4:439–45.
Miciński P, Pawlicki K, Wielgus E, Bochenek M, Gogol P, Ficek B. Total reactive antioxidant potential and DNA fragmentation index as fertility sperm parameters. Reprod Biol. 2011;11:135-44.
Duru NK, Morshedi M, Oehninger S. Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa. Fertil Steril. 2000;74:1200–7.
Ménézo Y, Entezami F, Lichtblau I, Belloc S, Cohen M, Dale B. Oxidative stress and fertility: incorrect assumptions and ineffective solutions? Zygote. 2012;12:1-11.
Lopes S, Jurisicova A, Sun J. Reactive oxygen species: a potential cause for DNA fragmentation in human spermatozoa. Hum Reprod. 1998;13:896–900.
Twigg J, Irvine DS, Aitken RJ. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod. 1998;13:1864–71.
Shamsi MB, Kumar R, Malhotra N, Singh N, Mittal S, Upadhyay AD, Dada R. Chromosomal aberrations, Yq microdeletion, and sperm DNA fragmentation in infertile men opting for assisted reproduction. Mol Reprod Dev. 2012;9.
Bontekoe S, Mantikou E, van Wely M, Seshadri S, Repping S, Mastenbroek S. Low oxygen concentrations for embryo culture in assisted reproductive technologies.Cochrane Database Syst Rev. 2012;11;7:008950.
Sakkas D, Mariethoz E, Manicardi G. Origin of DNA damage in ejaculated human spermatozoa. Rev Reprod. 1999;4:31–7. 51.
Gong S, San Gabriel MC, Zini A, Chan P, O’Flaherty C. Low Amounts and High Thiol Oxidation of Peroxiredoxins in Spermatozoa from Infertile Men. J Androl. 2012;5.
Nirupama M, Devaki M, Nirupama R, Yajurvedi HN. Chronic intermittent stress-induced alterations in the spermatogenesis and anti oxidant status of the testis are irreversible in albino rat. J Physiol Biochem. 2012;21.
Tartibian B, Maleki BH. Correlation between seminal oxidative stress biomarkers and antioxidants with sperm DNA damage in elite athletes and recreationally active men. Clin J Sport Med. 2012;22:132-9.
Shukla KK, Mahdi AA, Rajender S. Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed). 2012;4:746-54.
Said TM, Paasch U, Glander HJ. Role of caspases in male infertility. Hum Reprod Update. 2004;10:39.
Roessner C, Paasch U, Kratzsch J, Glander HJ, Grunewald S. Sperm apoptosis signalling in diabetic men. Reprod Biomed Online. 2012;19. 57. Agarwal A. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril. 2003;80:531-5.
Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79:829-43.
Niederberger C. Re: The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. J Urol. 2012;187:1377.
Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2011;19:CD007411.
Shiva M, Gautam AK, Verma Y, Shivgotra V, Doshi H, Kumar S. Association between sperm quality, oxidative stress, and seminal antioxidant activity. Clin Biochem. 2011;44:319-24.
Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int. 2010;7.
Juan ME, Gonzalez-Pons E, Munuera T et al. Trans-resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr. 2005;135:757-60.
Fernandes GS, Fernandez CD, Campos KE, Damasceno DC, Anselmo-Franci JA, Kempinas WD. Vitamin C partially attenuates male reproductive deficits in hyperglycemic rats. Reprod Biol Endocrinol. 2011;27;9:100.
Gharagozloo P, Aitken RJ. The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod. 2011l;26:1628-40.
Blackman MR, Wang C, Swerdloff RS. The role of carnitine in the male reproductive system. Ann N Y Acad Sci. 2004;1033:177-88.
Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso Sl. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial. Fertil Steril. 2009;91:1785-92.
Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2009;91:1785-92.
Colagar AH, Marzony ET, Chaichi MJ: Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009;29:82-8.
Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77:491-8.
Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74:73-6.
Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181:741-51.
Wang N, Qian HY, Zhou XQ, Li YB, Sun ZW. Mitochondrial energy metabolism dysfunction involved in reproductive toxicity of mice caused by endosulfan and protective effects of vitamin E.Ecotoxicol Environ Saf. 2012;82:96-103.
Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005;26:349-53.
Hampl R, Drábková P, Kanďár R, Stěpán J. Impact of oxidative stress on male infertility.Ceska Gynekol. 2012;77:241-5.
Tvrdá E, Kňažická Z, Bárdos L, Massányi P, Lukáč N. Impact of oxidative stress on male fertility - a review. Acta Vet Hung. 2011;59:465-84.
Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996;48:835–50.
Gomez E, Buckingham DW, Brindle J. Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: correlation with biochemical markers of the cytoplasmic space, oxidative stress, and sperm function. J Androl. 1996;17:276.
Agarwal A, Saleh RA. Urol Clin N Am. 2002;29:817–27.
Henkel RR. Leukocytes and oxidative stress: dilemma for sperm function and male fertility.Asian J Androl. 2011;13:43-52.
Armstrong JS, Rajasekaran M, Chamulitrat W. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999;26:869.
Griveau JF and Le Lannou D: Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl. 1997;20:61.
Agarwal A, Nallella KP, Allamaneni SS. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online. 2004;8:616.
Hunter RH and Rodriguez-Martinez H. Capacitation of mammalian spermatozoa in vivo, with a specific focus on events in the fallopian tubes. Mol Reprod Dev. 2004; 67:243.
Zini A, de Lamirande E, Gagnon C. Low levels of nitric oxide promote human sperm capacitation in vitro. J Androl. 1996;16:424– 31.
Visconti PE, Moore GD, Bailey JL. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development. 1995;121:1139.
de Lamirande E, Leclerc P and Gagnon C. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 1997;3:175-8.
Kodama H, Kuribayashi Y and Gagnon C. Effect of sperm lipid peroxidation on fertilization. J Androl. 1996;17:151.
Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod. 1989;40:183–97.
Aitken RJ, Paterson M, Fisher H. Redox regulation of tyrosine phosphorylation in human spermatozoa is involved in the control of human sperm function. J Cell Sci 1995;108:2017–25.
Helbock HJ, Beckman KB, Shigenaga MK. DNA oxidation matters: the HPLCelectrochemical detection assay of 8-oxo-de- oxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci USA. 1998;95:288.
Tuğcu V, Gedikbaşi A, Mutlu B, Güner E, Uhri M, Andican G, Ozbek E, Taşçi AI. Increased testicular 8-hydroxy-2’-deoxyguanosine (8-OHdG) and inducible nitric oxide synthetase (iNOS) and nuclear factor κB (NF-κB) expressions in experimental rat varicocele. Arch Ital Urol Androl. 2010;82:148-53.
Simsek A, Ozbek E, Ilbey YO, Cekmen M, Somay A, Tasci AI. Potential role of p38- mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: an experimental study. Andrologia. 2011;15.
Piomboni P, Stendardi A, Gambera L, Tatone C, Coppola L, De Leo V, Focarelli R. Protein modification as oxidative stress marker in normal and pathological human seminal plasma.Redox Rep. 2012;7.
Agarwal A and Said TM. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update. 2003;9:331.
Sharma RK, Said T and Agarwal A. Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Asian J Androl. 2004;6:139.
Sakkas D, Urner F, Bizzaro D. Sperm nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo development. Hum Reprod 1998;13:11.
Sakkas D, Seli E, Bizzaro D. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reprod Biomed Online. 2003;7:428.
Alvarez JG, Sharma RK, Ollero M. Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay. Fertil Steril 2002;78:319.
Sikka SC. Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J Androl. 2004;25:5.
Kao S, Chao HT and Wei YH. Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm. Biol Reprod. 1995;52:729.
Diemer T, Allen JA, Hales KH et al. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 2003;144:2882.
Bennetts LE and Aitken RJ. A comparative study of oxidative DNA damage in mammalian spermatozoa. Mol Reprod Dev. 2005;71:77.
Agarwal A and Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503.
Yakes FM and Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 1997;94:514.
Halliwell B. Tell me about free radicals, doctor: a review. J R Soc Med. 1984;82:747–52.
Aitken RJ, Harkiss D, Buckingham D. Relationship between iron-catalyzed lipid peroxidation potential and human sperm function. J Reprod Ferti.l 1993;98:257–65.
Akyol O, Ozbek E, Uz E, Koçak I. Malondialdehyde level and total superoxide dismutase activity in seminal fluid from patients withvaricocele. Clin Exp Med. 2001;1:67-8.
Ozbek E, Cekmen M, Simsek A, Turkoz Y, Soylu A, Ilbey YO, Balbay MD. Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele. Int Urol Nephrol. 2008;40:679-83.
Wang X, Liu N. Sperm DNA oxidative damage in patients with idiopathic asthenozoospermia. 2012;37:100-5.
Agarwal A, Ikemoto I, Loughlin KR. Relationship of sperm parameters to levels of reactive oxygen species in semen specimens. J Urol. 1994;152:107–10.
Griveau JF, Dumont E, Renard B, et al. Reactive oxygen species, lipid peroxidation and enzymatic defense systems in human spermatozoa. J Reprod Fertil. 1995;103:17–26.
Ozbek E, Ilbey YY, Simşek A, Cekmen M, Balbay MD. Preoperative and postoperative seminal nitric oxide levels in patients with infertile varicocele. Arch Ital Urol Androl. 2009;81:248-50.
Ozbek E, Turkoz Y, Gokdeniz R, Davarci M, Ozugurlu F. Increased nitric oxide produc- tion in the spermatic vein of patients with varicocele. Eur Urol. 2000;37:172-5.
Twigg J, Irvine DS, Houston P, et al. IatrogenicDNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Mol Hum Reprod. 1998;4:439–45.
Miciński P, Pawlicki K, Wielgus E, Bochenek M, Gogol P, Ficek B. Total reactive antioxidant potential and DNA fragmentation index as fertility sperm parameters. Reprod Biol. 2011;11:135-44.
Duru NK, Morshedi M, Oehninger S. Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa. Fertil Steril. 2000;74:1200–7.
Ménézo Y, Entezami F, Lichtblau I, Belloc S, Cohen M, Dale B. Oxidative stress and fertility: incorrect assumptions and ineffective solutions? Zygote. 2012;12:1-11.
Lopes S, Jurisicova A, Sun J. Reactive oxygen species: a potential cause for DNA fragmentation in human spermatozoa. Hum Reprod. 1998;13:896–900.
Twigg J, Irvine DS, Aitken RJ. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod. 1998;13:1864–71.
Shamsi MB, Kumar R, Malhotra N, Singh N, Mittal S, Upadhyay AD, Dada R. Chromosomal aberrations, Yq microdeletion, and sperm DNA fragmentation in infertile men opting for assisted reproduction. Mol Reprod Dev. 2012;9.
Bontekoe S, Mantikou E, van Wely M, Seshadri S, Repping S, Mastenbroek S. Low oxygen concentrations for embryo culture in assisted reproductive technologies.Cochrane Database Syst Rev. 2012;11;7:008950.
Sakkas D, Mariethoz E, Manicardi G. Origin of DNA damage in ejaculated human spermatozoa. Rev Reprod. 1999;4:31–7. 51.
Gong S, San Gabriel MC, Zini A, Chan P, O’Flaherty C. Low Amounts and High Thiol Oxidation of Peroxiredoxins in Spermatozoa from Infertile Men. J Androl. 2012;5.
Nirupama M, Devaki M, Nirupama R, Yajurvedi HN. Chronic intermittent stress-induced alterations in the spermatogenesis and anti oxidant status of the testis are irreversible in albino rat. J Physiol Biochem. 2012;21.
Tartibian B, Maleki BH. Correlation between seminal oxidative stress biomarkers and antioxidants with sperm DNA damage in elite athletes and recreationally active men. Clin J Sport Med. 2012;22:132-9.
Shukla KK, Mahdi AA, Rajender S. Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed). 2012;4:746-54.
Said TM, Paasch U, Glander HJ. Role of caspases in male infertility. Hum Reprod Update. 2004;10:39.
Roessner C, Paasch U, Kratzsch J, Glander HJ, Grunewald S. Sperm apoptosis signalling in diabetic men. Reprod Biomed Online. 2012;19. 57. Agarwal A. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril. 2003;80:531-5.
Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79:829-43.
Niederberger C. Re: The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. J Urol. 2012;187:1377.
Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2011;19:CD007411.
Shiva M, Gautam AK, Verma Y, Shivgotra V, Doshi H, Kumar S. Association between sperm quality, oxidative stress, and seminal antioxidant activity. Clin Biochem. 2011;44:319-24.
Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int. 2010;7.
Juan ME, Gonzalez-Pons E, Munuera T et al. Trans-resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr. 2005;135:757-60.
Fernandes GS, Fernandez CD, Campos KE, Damasceno DC, Anselmo-Franci JA, Kempinas WD. Vitamin C partially attenuates male reproductive deficits in hyperglycemic rats. Reprod Biol Endocrinol. 2011;27;9:100.
Gharagozloo P, Aitken RJ. The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod. 2011l;26:1628-40.
Blackman MR, Wang C, Swerdloff RS. The role of carnitine in the male reproductive system. Ann N Y Acad Sci. 2004;1033:177-88.
Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso Sl. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial. Fertil Steril. 2009;91:1785-92.
Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2009;91:1785-92.
Colagar AH, Marzony ET, Chaichi MJ: Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009;29:82-8.
Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77:491-8.
Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74:73-6.
Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181:741-51.
Wang N, Qian HY, Zhou XQ, Li YB, Sun ZW. Mitochondrial energy metabolism dysfunction involved in reproductive toxicity of mice caused by endosulfan and protective effects of vitamin E.Ecotoxicol Environ Saf. 2012;82:96-103.
Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005;26:349-53.
Sayfalar
77-88
Gelecek
30 Nisan 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Kazaz İO, Atnallar G. Oksidatif Stres, Sperm DNA Hasarı ve Tedavisi. Içinde: Turgut H, editör. Güncel Üroloji Çalışmaları V (Bahar) [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 77-88. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/3059/chapter/13463
