Kedi Otu (Valeriana Officinalis)
Özet
Valeriana L. Caprifoliaceae familyasına ait çok yıllık bir bitki grubudur. Valeriana ailesinin Avrupa ve ABD de en yaygın kullanılan cinsi Valeriana officinalistir (kedi otu). Kedi otunun kendine has bir kokusu vardır. Hipokrat zamanından bu yana geleneksel olarak kullanıldığı bilinmektedir. Valeriana officinalis GABA üzerinden sedatif etkilerini oluşturmaktadır. İçeriğinde farklı iridoid türleri vardır. Valeriana officinalis daha çok uyku bozuklukları için sedatif özelliği nedeniyle kullanılmaktadır Yapısındaki farklı etken maddeler nedeniyle birçok alanda kullanımı mevcuttur. Kanser tedavisi yönünden sınırlı sayıda çalışma mevcuttur. Valerianadan elde edilen metabolitlerinin incelendiği çoğu invitro olan çalışmalarda kanser üzerine olumlu etkileri bildirilmektedir.
Valeriana L. is a group of perennial plants belonging to the Caprifoliaceae family. The most widely used genus of the Valeriana family in Europe and the USA is Valeriana officinalis (valerian) (cat’s love) Valerian has an unique smell. Traditionally it has been used since the time of Hippocrates. Valeriana officinalis produces its sedative effects through GABA and also contains different types of iridoids. Valeriana officinalis is mostly used for sleep disorders due to its sedative effect. It is used in many clicial situations due to the different active ingredients in its structure. There are a limited number of studies regarding about cancer treatment. Mostly in vitro studies examining the metabolites obtained from valeriana have positive effects on cancer.
Referanslar
Li J, Li X, Wang C, Zhang M, Ye M, Wang Q. The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry. Frontiers in pharmacology. 2022;13:973138.
Karamanoğlu K, Koyuncu M. Türkiye Valeriana (Kediotu) türleri üzerinde sistematik araştırmalar, Ankara Ecz. Fak Der. 1974;4(1):149-78.
Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine. Expanded commission E monographs: Integrative Medicine Communications; 2000.
Han R, Nusbaum O, Chen X, Zhu Y. Valeric acid suppresses liver cancer development by acting as a novel HDAC inhibitor. Molecular Therapy-Oncolytics. 2020;19:8-18.
Wang F, Zhang Y, Zheng X, Dai Z, Liu B, Ma S. Research progress of the structure and biological activities of iridoids compounds. China Acad J Electron Publ House. 2019;33:91-8.
Zuo Y, Wang Y, Zhang Z, Yan H, Xu Y. Study on the chemical components of lignans of Valeriana officinalis. J Chin Med Mat. 2018;41:1091-4.
Jugran AK, Bahukhandi A, Dhyani P, Bhatt ID, Rawal RS, Nandi SK. Impact of altitudes and habitats on valerenic acid, total phenolics, flavonoids, tannins, and antioxidant activity of Valeriana jatamansi. Applied biochemistry and biotechnology. 2016;179:911-26.
Wang PC, Ran XH, Chen R, Luo HR, Ma QY, Liu YQ, et al. Sesquiterpenoids and lignans from the roots of Valeriana officinalis L. Chemistry & Biodiversity. 2011;8(10):1908-13.
Torssell K, Wahlberg K. Isolation, structure and synthesis of alkaloids from Valeriana officinalis L. L Acta Chem Scand. 1967;21(1):53-62.
Santos MS, Ferreira F, Cunha AP, Carvalho AP, Macedo T. An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Medica. 1994;60(03):278-9.
Morazzoni P, Bombardelli E. Valeriana officinalis: Traditional used and recent evaluation of activity. Fitoterapia (Milano). 1995;66(2):99-112.
Torres-Hernández BA, Del Valle-Mojica LM, Ortíz JG. Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). BMC complementary and alternative medicine. 2015;15:1-10.
Han R, Nusbaum O, Chen X, Zhu Y. Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor. Molecular therapy oncolytics. 2020;19:8-18.
Mishra MK, Kukal S, Paul PR, Bora S, Singh A. Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile. 2021;27(1).
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007;109(1):31-9.
Wang R-J, Huang Q, Yong Y, Li H-X, Zhang S-J, Chen B-H, et al. Studies on chemical constituents of Valeriana plants and their biological activities. Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica. 2016;41(8):1405-14.
Li J, Li X, Wang C, Zhang M, Ye M, Wang Q. The potential of Valeriana as a traditional Chinese medicine: Traditional clinical applications, bioactivities, and phytochemistry. Frontiers in pharmacology. 2022;13:973138.
Valle-Mojica D, Lisa M, Cordero-Hernández JM, González-Medina G, Ramos-Vélez I, Berríos-Cartagena N, et al. Aqueous and ethanolic Valeriana officinalis extracts change the binding of ligands to glutamate receptors. Evidence-Based Complementary and Alternative Medicine. 2011;2011.
Orhan IE. A review focused on molecular mechanisms of anxiolytic effect of Valerina officinalis L. in connection with its phytochemistry through in vitro/in vivo studies. Current Pharmaceutical Design. 2021;27(28):3084-90.
Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo‐controlled pilot study. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2002;16(7):650-4.
Eadie MJ. Could valerian have been the first anticonvulsant? Epilepsia. 2004;45(11):1338-43.
Malva JO, Santos S, Macedo T. Neuroprotective properties of Valeriana officinalis extracts. Neurotoxicity research. 2004;6:131-40.
Rawat S, Jugran AK, Bhatt ID, Rawal RS, Andola HC, Dhar U. Essential oil composition and antioxidant activity in Valeriana jatamansi Jones: influence of seasons and growing sources. Journal of EssEntial oil rEsEarch. 2017;29(1):101-7.
Yang B, Zhu R, Tian S, Wang Y, Lou S, Zhao H. Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo. Biomedicine & Pharmacotherapy. 2017;89:1027-36.
Xue C, HE X, QU W, LI Y, Zeng L, Peng R. Improvement of Valerian-ligusticum extract on cerebral microcirculatory disturbance. Chinese Journal of Tissue Engineering Research. 2005:171-4.
Chen H-W, Wei B-J, He X-H, Liu Y, Wang J. Chemical components and cardiovascular activities of Valeriana spp. Evidence-Based Complementary and Alternative Medicine. 2015;2015.
Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders—A systematic review and meta-analysis. Journal of Evidence-Based Integrative Medicine. 2020;25:2515690X20967323.
Tian S, Wang Z, Wu Z, Wei Y, Yang B, Lou S. Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro. Natural product research. 2020;34(18):2660-3.
Tan Y-Z, Peng C, Hu C-J, Li H-X, Li W-B, He J-L, et al. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells. Bioorganic Chemistry. 2019;87:136-41.
Lin S, Fu P, Chen T, Ye J, Su Y-Q, Yang X-W, et al. Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Planta medica. 2014:56-61.
Liu X, Hu Y, Xue Z, Zhang X, Liu X, Liu G, et al. Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway. Journal of Translational Medicine. 2023;21(1):1-19.
Chen L, Feng D, Qian Y, Cheng X, Song H, Qian Y, et al. Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling. Phytomedicine. 2021;85:153537.
Bos R, Hendriks H, Scheffer JJ, Woerdenbag HJ. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine. 1998;5(3):219-25.
Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, et al. Valerian inhibits rat hepatocarcinogenesis by activating GABA (A) receptor-mediated signaling. PLoS One. 2014;9(11):e113610.
Lin S, Fu P, Chen T, Ye J, Su YQ, Yang XW, et al. Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Planta Med. 2015;81(1):56-61.
Matsumoto T, Yoshikawa H, Kitagawa T, Imahori D, Ohta T, Yoshida T, et al. Chemical Structures and Anti-proliferative Effects of Valeriana fauriei Constituents on Cancer Stem Cells. Chemical & pharmaceutical bulletin. 2023;71(7):495-501.
Kara M, Alparslan ED. In Vitro Cytotoxicity and Oxidative Stress Evaluation of Valerian (Valeriana officinalis) Methanolic Extract in Hepg2 and Caco2 Cells. 2021;18(5):604-8.
Shi F, Li Y, Han R, Fu A, Wang R, Nusbaum O, et al. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021;11(1):2519.
Davidson JR, MacLean AW, Brundage MD, Schulze K. Sleep disturbance in cancer patients. Social science & medicine (1982). 2002;54(9):1309-21.
Kelber O, Nieber K, Kraft K. Valerian: no evidence for clinically relevant interactions. Evidence-Based Complementary and Alternative Medicine: eCAM. 2014;2014.
Block KI, Gyllenhaal C, Mead MN. Safety and efficacy of herbal sedatives in cancer care. Integr Cancer Ther. 2004;3(2):128-48.
Karamanoğlu K, Koyuncu M. Türkiye Valeriana (Kediotu) türleri üzerinde sistematik araştırmalar, Ankara Ecz. Fak Der. 1974;4(1):149-78.
Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine. Expanded commission E monographs: Integrative Medicine Communications; 2000.
Han R, Nusbaum O, Chen X, Zhu Y. Valeric acid suppresses liver cancer development by acting as a novel HDAC inhibitor. Molecular Therapy-Oncolytics. 2020;19:8-18.
Wang F, Zhang Y, Zheng X, Dai Z, Liu B, Ma S. Research progress of the structure and biological activities of iridoids compounds. China Acad J Electron Publ House. 2019;33:91-8.
Zuo Y, Wang Y, Zhang Z, Yan H, Xu Y. Study on the chemical components of lignans of Valeriana officinalis. J Chin Med Mat. 2018;41:1091-4.
Jugran AK, Bahukhandi A, Dhyani P, Bhatt ID, Rawal RS, Nandi SK. Impact of altitudes and habitats on valerenic acid, total phenolics, flavonoids, tannins, and antioxidant activity of Valeriana jatamansi. Applied biochemistry and biotechnology. 2016;179:911-26.
Wang PC, Ran XH, Chen R, Luo HR, Ma QY, Liu YQ, et al. Sesquiterpenoids and lignans from the roots of Valeriana officinalis L. Chemistry & Biodiversity. 2011;8(10):1908-13.
Torssell K, Wahlberg K. Isolation, structure and synthesis of alkaloids from Valeriana officinalis L. L Acta Chem Scand. 1967;21(1):53-62.
Santos MS, Ferreira F, Cunha AP, Carvalho AP, Macedo T. An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Medica. 1994;60(03):278-9.
Morazzoni P, Bombardelli E. Valeriana officinalis: Traditional used and recent evaluation of activity. Fitoterapia (Milano). 1995;66(2):99-112.
Torres-Hernández BA, Del Valle-Mojica LM, Ortíz JG. Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). BMC complementary and alternative medicine. 2015;15:1-10.
Han R, Nusbaum O, Chen X, Zhu Y. Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor. Molecular therapy oncolytics. 2020;19:8-18.
Mishra MK, Kukal S, Paul PR, Bora S, Singh A. Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile. 2021;27(1).
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007;109(1):31-9.
Wang R-J, Huang Q, Yong Y, Li H-X, Zhang S-J, Chen B-H, et al. Studies on chemical constituents of Valeriana plants and their biological activities. Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica. 2016;41(8):1405-14.
Li J, Li X, Wang C, Zhang M, Ye M, Wang Q. The potential of Valeriana as a traditional Chinese medicine: Traditional clinical applications, bioactivities, and phytochemistry. Frontiers in pharmacology. 2022;13:973138.
Valle-Mojica D, Lisa M, Cordero-Hernández JM, González-Medina G, Ramos-Vélez I, Berríos-Cartagena N, et al. Aqueous and ethanolic Valeriana officinalis extracts change the binding of ligands to glutamate receptors. Evidence-Based Complementary and Alternative Medicine. 2011;2011.
Orhan IE. A review focused on molecular mechanisms of anxiolytic effect of Valerina officinalis L. in connection with its phytochemistry through in vitro/in vivo studies. Current Pharmaceutical Design. 2021;27(28):3084-90.
Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo‐controlled pilot study. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2002;16(7):650-4.
Eadie MJ. Could valerian have been the first anticonvulsant? Epilepsia. 2004;45(11):1338-43.
Malva JO, Santos S, Macedo T. Neuroprotective properties of Valeriana officinalis extracts. Neurotoxicity research. 2004;6:131-40.
Rawat S, Jugran AK, Bhatt ID, Rawal RS, Andola HC, Dhar U. Essential oil composition and antioxidant activity in Valeriana jatamansi Jones: influence of seasons and growing sources. Journal of EssEntial oil rEsEarch. 2017;29(1):101-7.
Yang B, Zhu R, Tian S, Wang Y, Lou S, Zhao H. Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo. Biomedicine & Pharmacotherapy. 2017;89:1027-36.
Xue C, HE X, QU W, LI Y, Zeng L, Peng R. Improvement of Valerian-ligusticum extract on cerebral microcirculatory disturbance. Chinese Journal of Tissue Engineering Research. 2005:171-4.
Chen H-W, Wei B-J, He X-H, Liu Y, Wang J. Chemical components and cardiovascular activities of Valeriana spp. Evidence-Based Complementary and Alternative Medicine. 2015;2015.
Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders—A systematic review and meta-analysis. Journal of Evidence-Based Integrative Medicine. 2020;25:2515690X20967323.
Tian S, Wang Z, Wu Z, Wei Y, Yang B, Lou S. Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro. Natural product research. 2020;34(18):2660-3.
Tan Y-Z, Peng C, Hu C-J, Li H-X, Li W-B, He J-L, et al. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells. Bioorganic Chemistry. 2019;87:136-41.
Lin S, Fu P, Chen T, Ye J, Su Y-Q, Yang X-W, et al. Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Planta medica. 2014:56-61.
Liu X, Hu Y, Xue Z, Zhang X, Liu X, Liu G, et al. Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway. Journal of Translational Medicine. 2023;21(1):1-19.
Chen L, Feng D, Qian Y, Cheng X, Song H, Qian Y, et al. Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling. Phytomedicine. 2021;85:153537.
Bos R, Hendriks H, Scheffer JJ, Woerdenbag HJ. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine. 1998;5(3):219-25.
Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, et al. Valerian inhibits rat hepatocarcinogenesis by activating GABA (A) receptor-mediated signaling. PLoS One. 2014;9(11):e113610.
Lin S, Fu P, Chen T, Ye J, Su YQ, Yang XW, et al. Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Planta Med. 2015;81(1):56-61.
Matsumoto T, Yoshikawa H, Kitagawa T, Imahori D, Ohta T, Yoshida T, et al. Chemical Structures and Anti-proliferative Effects of Valeriana fauriei Constituents on Cancer Stem Cells. Chemical & pharmaceutical bulletin. 2023;71(7):495-501.
Kara M, Alparslan ED. In Vitro Cytotoxicity and Oxidative Stress Evaluation of Valerian (Valeriana officinalis) Methanolic Extract in Hepg2 and Caco2 Cells. 2021;18(5):604-8.
Shi F, Li Y, Han R, Fu A, Wang R, Nusbaum O, et al. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021;11(1):2519.
Davidson JR, MacLean AW, Brundage MD, Schulze K. Sleep disturbance in cancer patients. Social science & medicine (1982). 2002;54(9):1309-21.
Kelber O, Nieber K, Kraft K. Valerian: no evidence for clinically relevant interactions. Evidence-Based Complementary and Alternative Medicine: eCAM. 2014;2014.
Block KI, Gyllenhaal C, Mead MN. Safety and efficacy of herbal sedatives in cancer care. Integr Cancer Ther. 2004;3(2):128-48.
Sayfalar
221-224
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Sali M. Kedi Otu (Valeriana Officinalis). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 221-4. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13920
