Ökse Otu (Mistletoe)
Özet
Mistletoe(ökse otu) çeşitli bitkilere bağlı yaşabilen hemiparaziter bir bitkidir. Bazı medeniyetlerde yeryüzüne inmeyen bitki olarak görülmüş ve çeşitli anlamlar yüklenmiştir. Geleneksel halk tıbbında hipertansiyon, diyabet, nörolojik hastalıklar, ishal gibi bircok hastalıkta kullanılmış. Mistletoe bitkisinin cok sayıda çeşidi ve üzerinde yaşadığı çok sayıda bitki ve çallı çeşidi mevcut. Almanya, Avusturya ve Kore gibi ülkelerde standart mistletoe ekstraktların subkutan formları mevcuttur. Mistletoe ekstraktının çok sayıda preklinik çalışmaları mevcuttur. Onkoloji hastalıklarında ise başta meme kanseri, baş-boyun kanseri, gastrointestinal kanserler, jinekolojik kanserler, gliomalar, pankreas kanseri gibi birçok kanserde randomize ve kontrollü çalışmaları mevcuttur. Bazı çalışmalarda mistletoe ekstraktlarının sağkalım faydası görünse de sıklıkla kemoterapiye bağlı yan etkileri azaltığı ve yaşam kalitesini iyileştirdiği görülmüş. Kemoterapi alan hastalarda eş zamanlı mistletoe ekstraktı kullanımının klinik olarak anlamlı bir ilaç etkileşimi görülmemiş.
Mistletoe is a hemiparasitic plant that can live attached to various plants. In some cultures, it was regarded as a plant that never touched the ground and was ascribed various meanings. It has been used in public medicine for numerous conditions, including hypertension, diabetes, neurological diseases and diarrhea. There are many species of mistletoe plants, and it can be found on various types of plants and shrubs. Subcutaneous forms of standard mistletoe extracts are available in countries like Germany, Austria and Korea. Numerous preclinical studies have explored the potential benefits of mistletoe extract. In the oncology, there have been randomized and controlled studies in various types of cancer, including breast cancer, head and neck cancer, gastrointestinal cancers, gynecological cancers, gliomas, and pancreatic cancer. Although mistletoe extracts seem to demonstrate a survival benefit in some studies, they have often been shown to reduce chemotherapy-related side effects and improve quality of life. No clinically significant drug interactions have been observed when using mistletoe extract concurrently with chemotherapy treatments.
Referanslar
Türe C, Böcük H, Aşan Z. Nutritional relationships between hemi-parasitic mistletoe and some of its deciduous hosts in different habitats. Biologia. 2010;65:859-67.
Zänker KS, Kaveri SV. Mistletoe: From mythology to evidence-based medicine: Karger Medical and Scientific Publishers; 2015.
Peaden PA. Mistletoe, The Genus Viscum Edited by Arndt Büssing (University Witten Herdecke, Germany). Harwood Academic Publishers, The Netherlands. 2000. xv+ 266 pp. 17× 24.5 cm. $105.00. ISBN 90-5823-092-9. ACS Publications; 2001.
Szurpnicka A, Kowalczuk A, Szterk A. Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action. Arch Pharm Res. 2020;43:593-629.
Freuding M, Keinki C, Micke O, Buentzel J, Huebner J. Mistletoe in oncological treatment: a systematic review: part 1: survival and safety. J Cancer Res Clin Oncol. 2019;145:695-707.
Mishra R, Sharma S, Sharma RS, Singh S, Sardesai MM, Sharma S, et al. Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells. J Ethnopharmacol. 2018;219:91-102.
Khan T, Ali S, Qayyum R, Hussain I, Wahid F, Shah AJ. Intestinal and vascular smooth muscle relaxant effect of Viscum album explains its medicinal use in hyperactive gut disorders and hypertension. BMC Complement Altern Med. 2016;16(1):1-8.
Park J-H, Kim YN, Kim J-K, Park H-Y, Song B-S. Viscothionin purified from mistletoe (Viscum album var. coloratum Ohwi) induces insulin secretion from pancreatic beta cells. J Ethnopharmacol. 2019;234:172-9.
Jiang Y, Wang C, Li Y-Y, Wang X-C, An J-D, Wang Y-J, et al. Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference. J Ethnopharmacol. 2014;158:230-8.
Jäger AK, Saaby L. Flavonoids and the CNS. Molecules. 2011;16(2):1471-85.
Kim MJ, Park J-H, Kwon DY, Yang HJ, Kim DS, Kang S, et al. The supplementation of Korean mistletoe water extracts reduces hot flushes, dyslipidemia, hepatic steatosis, and muscle loss in ovariectomized rats. Exp Biol Med. 2015;240(4):477-87.
Lee S-H, Kim I-B, Kim J-B, Park D-H, Min K-J. The effects of Korean mistletoe extract on endurance during exercise in mice. Animal Cells and Systems. 2014;18(1):34-40.
Sakalli Çetin E, Tetiker H, İlhan Çelik Ö, Yılmaz N, Ciğerci İH. Methotrexate-induced nephrotoxicity in rats: protective effect of mistletoe (Viscum album L.) extract. Complementary medicine research. 2017;24(6):364-70.
Kuonen R, Weissenstein U, Urech K, Kunz M, Hostanska K, Estko M, et al. Effects of lipophilic extract of Viscum album L. and oleanolic acid on migratory activity of NIH/3T3 fibroblasts and on HaCat keratinocytes. Evid Based Complement Alternat Med. 2013;2013.
Hussain MA, Khan MQ, Hussain N, Habib T. Antibacterial and antifungal potential of leaves and twigs of Viscum album L. Journal of Medicinal Plants Research. 2011;5(23):5545-9.
Schink M, Dehus O. Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities. BMC Complement Altern Med. 2017;17(1):521.
Doehmer J, Eisenbraun J. Assessment of extracts from mistletoe (Viscum album) for herb-drug interaction by inhibition and induction of cytochrome P450 activities. Phytother Res. 2012;26(1):11-7.
Weissenstein U, Kunz M, Urech K, Baumgartner S. Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. BMC Complement Altern Med. 2014;14:6.
Steele ML, Axtner J, Happe A, Kröz M, Matthes H, Schad F. Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Evid Based Complement Alternat Med. 2014;2014:724258.
Grossarth-Maticek R, Ziegler R. Prospective Controlled Cohort Studies on Long-Term Therapy of Breast Cancer Patients with a Mistletoe Preparation (Iscador®). Forschende Komplementärmedizin / Research in Complementary Medicine. 2006;13(5):285-92.
Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth J, et al. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res. 2004;24(1):303-9.
Semiglazov VF, Stepula VV, Dudov A, Schnitker J, Mengs U. Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2006;26(2b):1519-29.
Schumacher K, Schneider B, Reich G, Stiefel T, Stoll G, Bock PR, et al. Influence of postoperative complementary treatment with lectin-standardized mistletoe extract on breast cancer patients. A controlled epidemiological multicentric retrolective cohort study. Anticancer Res. 2003;23(6d):5081-7.
Pelzer F, Tröger W, Nat DR. Complementary Treatment with Mistletoe Extracts During Chemotherapy: Safety, Neutropenia, Fever, and Quality of Life Assessed in a Randomized Study. J Altern Complement Med. 2018;24(9-10):954-61.
Semiglasov VF, Stepula VV, Dudov A, Lehmacher W, Mengs U. The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2004;24(2c):1293-302.
Bock PR, Friedel WE, Hanisch J, Karasmann M, Schneider B. [Efficacy and safety of long-term complementary treatment with standardized European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncologic therapy in patients with primary non-metastasized mammary carcinoma. Results of a multi-center, comparative, epidemiological cohort study in Germany and Switzerland]. Arzneimittelforschung. 2004;54(8):456-66.
Cazacu M, Oniu T, Lungoci C, Mihailov A, Cipak A, Klinger R, et al. The influence of isorel on the advanced colorectal cancer. Cancer Biother Radiopharm. 2003;18(1):27-34.
Grossarth-Maticek R, Kiene H, Baumgartner SM, Ziegler R. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med. 2001;7(3):57-66, 8-72, 4-6 passim.
Lenartz D, Stoffel B, Menzel J, Beuth J. Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients. Anticancer Res. 1996;16(6b):3799-802.
Steuer-Vogt MK, Bonkowsky V, Ambrosch P, Scholz M, Neiss A, Strutz J, et al. The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial. Eur J Cancer. 2001;37(1):23-31.
Bar-Sela G, Wollner M, Hammer L, Agbarya A, Dudnik E, Haim N. Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: a randomised phase II study. Eur J Cancer. 2013;49(5):1058-64.
Kleeberg UR, Suciu S, Bröcker EB, Ruiter DJ, Chartier C, Liénard D, et al. Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. rIFN-alpha2b versus rIFN-gamma versus ISCADOR M versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis. Eur J Cancer. 2004;40(3):390-402.
Longhi A, Reif M, Mariani E, Ferrari S. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evid Based Complement Alternat Med. 2014;2014:210198.
Tröger W, Galun D, Reif M, Schumann A, Stanković N, Milićević M. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Eur J Cancer. 2013;49(18):3788-97.
Enesel MB, Acalovschi I, Grosu V, Sbarcea A, Rusu C, Dobre A, et al. Perioperative application of the Viscum album extract Isorel in digestive tract cancer patients. Anticancer Res. 2005;25(6c):4583-90.
Baek JH, Jeon Y, Han KW, Jung DH, Kim KO. Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study. World J Surg Oncol. 2021;19(1):178.
Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of cervical cancer patients with a mistletoe preparation (Iscador). Forsch Komplementmed. 2007;14(3):140-7.
Grossarth-Maticek R, Ziegler R. Randomized and non-randomized prospective controlled cohort studies in matched pair design for the long-term therapy of corpus uteri cancer patients with a mistletoe preparation (Iscador). Eur J Med Res. 2008;13(3):107-20.
Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of ovairian cancer patients with mistletoe (Viscum album L.) extracts iscador. Arzneimittelforschung. 2007;57(10):665-78.
Zänker KS, Kaveri SV. Mistletoe: From mythology to evidence-based medicine: Karger Medical and Scientific Publishers; 2015.
Peaden PA. Mistletoe, The Genus Viscum Edited by Arndt Büssing (University Witten Herdecke, Germany). Harwood Academic Publishers, The Netherlands. 2000. xv+ 266 pp. 17× 24.5 cm. $105.00. ISBN 90-5823-092-9. ACS Publications; 2001.
Szurpnicka A, Kowalczuk A, Szterk A. Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action. Arch Pharm Res. 2020;43:593-629.
Freuding M, Keinki C, Micke O, Buentzel J, Huebner J. Mistletoe in oncological treatment: a systematic review: part 1: survival and safety. J Cancer Res Clin Oncol. 2019;145:695-707.
Mishra R, Sharma S, Sharma RS, Singh S, Sardesai MM, Sharma S, et al. Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells. J Ethnopharmacol. 2018;219:91-102.
Khan T, Ali S, Qayyum R, Hussain I, Wahid F, Shah AJ. Intestinal and vascular smooth muscle relaxant effect of Viscum album explains its medicinal use in hyperactive gut disorders and hypertension. BMC Complement Altern Med. 2016;16(1):1-8.
Park J-H, Kim YN, Kim J-K, Park H-Y, Song B-S. Viscothionin purified from mistletoe (Viscum album var. coloratum Ohwi) induces insulin secretion from pancreatic beta cells. J Ethnopharmacol. 2019;234:172-9.
Jiang Y, Wang C, Li Y-Y, Wang X-C, An J-D, Wang Y-J, et al. Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference. J Ethnopharmacol. 2014;158:230-8.
Jäger AK, Saaby L. Flavonoids and the CNS. Molecules. 2011;16(2):1471-85.
Kim MJ, Park J-H, Kwon DY, Yang HJ, Kim DS, Kang S, et al. The supplementation of Korean mistletoe water extracts reduces hot flushes, dyslipidemia, hepatic steatosis, and muscle loss in ovariectomized rats. Exp Biol Med. 2015;240(4):477-87.
Lee S-H, Kim I-B, Kim J-B, Park D-H, Min K-J. The effects of Korean mistletoe extract on endurance during exercise in mice. Animal Cells and Systems. 2014;18(1):34-40.
Sakalli Çetin E, Tetiker H, İlhan Çelik Ö, Yılmaz N, Ciğerci İH. Methotrexate-induced nephrotoxicity in rats: protective effect of mistletoe (Viscum album L.) extract. Complementary medicine research. 2017;24(6):364-70.
Kuonen R, Weissenstein U, Urech K, Kunz M, Hostanska K, Estko M, et al. Effects of lipophilic extract of Viscum album L. and oleanolic acid on migratory activity of NIH/3T3 fibroblasts and on HaCat keratinocytes. Evid Based Complement Alternat Med. 2013;2013.
Hussain MA, Khan MQ, Hussain N, Habib T. Antibacterial and antifungal potential of leaves and twigs of Viscum album L. Journal of Medicinal Plants Research. 2011;5(23):5545-9.
Schink M, Dehus O. Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities. BMC Complement Altern Med. 2017;17(1):521.
Doehmer J, Eisenbraun J. Assessment of extracts from mistletoe (Viscum album) for herb-drug interaction by inhibition and induction of cytochrome P450 activities. Phytother Res. 2012;26(1):11-7.
Weissenstein U, Kunz M, Urech K, Baumgartner S. Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. BMC Complement Altern Med. 2014;14:6.
Steele ML, Axtner J, Happe A, Kröz M, Matthes H, Schad F. Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Evid Based Complement Alternat Med. 2014;2014:724258.
Grossarth-Maticek R, Ziegler R. Prospective Controlled Cohort Studies on Long-Term Therapy of Breast Cancer Patients with a Mistletoe Preparation (Iscador®). Forschende Komplementärmedizin / Research in Complementary Medicine. 2006;13(5):285-92.
Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth J, et al. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res. 2004;24(1):303-9.
Semiglazov VF, Stepula VV, Dudov A, Schnitker J, Mengs U. Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2006;26(2b):1519-29.
Schumacher K, Schneider B, Reich G, Stiefel T, Stoll G, Bock PR, et al. Influence of postoperative complementary treatment with lectin-standardized mistletoe extract on breast cancer patients. A controlled epidemiological multicentric retrolective cohort study. Anticancer Res. 2003;23(6d):5081-7.
Pelzer F, Tröger W, Nat DR. Complementary Treatment with Mistletoe Extracts During Chemotherapy: Safety, Neutropenia, Fever, and Quality of Life Assessed in a Randomized Study. J Altern Complement Med. 2018;24(9-10):954-61.
Semiglasov VF, Stepula VV, Dudov A, Lehmacher W, Mengs U. The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2004;24(2c):1293-302.
Bock PR, Friedel WE, Hanisch J, Karasmann M, Schneider B. [Efficacy and safety of long-term complementary treatment with standardized European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncologic therapy in patients with primary non-metastasized mammary carcinoma. Results of a multi-center, comparative, epidemiological cohort study in Germany and Switzerland]. Arzneimittelforschung. 2004;54(8):456-66.
Cazacu M, Oniu T, Lungoci C, Mihailov A, Cipak A, Klinger R, et al. The influence of isorel on the advanced colorectal cancer. Cancer Biother Radiopharm. 2003;18(1):27-34.
Grossarth-Maticek R, Kiene H, Baumgartner SM, Ziegler R. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med. 2001;7(3):57-66, 8-72, 4-6 passim.
Lenartz D, Stoffel B, Menzel J, Beuth J. Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients. Anticancer Res. 1996;16(6b):3799-802.
Steuer-Vogt MK, Bonkowsky V, Ambrosch P, Scholz M, Neiss A, Strutz J, et al. The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial. Eur J Cancer. 2001;37(1):23-31.
Bar-Sela G, Wollner M, Hammer L, Agbarya A, Dudnik E, Haim N. Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: a randomised phase II study. Eur J Cancer. 2013;49(5):1058-64.
Kleeberg UR, Suciu S, Bröcker EB, Ruiter DJ, Chartier C, Liénard D, et al. Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. rIFN-alpha2b versus rIFN-gamma versus ISCADOR M versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis. Eur J Cancer. 2004;40(3):390-402.
Longhi A, Reif M, Mariani E, Ferrari S. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evid Based Complement Alternat Med. 2014;2014:210198.
Tröger W, Galun D, Reif M, Schumann A, Stanković N, Milićević M. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Eur J Cancer. 2013;49(18):3788-97.
Enesel MB, Acalovschi I, Grosu V, Sbarcea A, Rusu C, Dobre A, et al. Perioperative application of the Viscum album extract Isorel in digestive tract cancer patients. Anticancer Res. 2005;25(6c):4583-90.
Baek JH, Jeon Y, Han KW, Jung DH, Kim KO. Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study. World J Surg Oncol. 2021;19(1):178.
Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of cervical cancer patients with a mistletoe preparation (Iscador). Forsch Komplementmed. 2007;14(3):140-7.
Grossarth-Maticek R, Ziegler R. Randomized and non-randomized prospective controlled cohort studies in matched pair design for the long-term therapy of corpus uteri cancer patients with a mistletoe preparation (Iscador). Eur J Med Res. 2008;13(3):107-20.
Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of ovairian cancer patients with mistletoe (Viscum album L.) extracts iscador. Arzneimittelforschung. 2007;57(10):665-78.
Sayfalar
165-172
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Arak H. Ökse Otu (Mistletoe). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 165-72. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13904
