Alfa Lipoik Asit
Özet
Son yıllarda tamamlayıcı ve geleneksel tıp kullanımı onkoloji alanında gittikçe artmaktadır. Kanser hastalarında vücutta oluşan oksidatif hasarı azaltmak için antioksidanların alınmasının faydası ve önemi sürekli vurgulanmaktadır. Biz de güçlü antioksidan, anti-inflamatuar ve apoptotik aktivitesi olan ve aynı zamanda günümüzde diyabetik hastalarda nöropati tedavisinde verilen alfa lipoik asitin faydalarını, alternatif tıpta kullanımını ve kanser hastalarının tedavisindeki yerinin önemini yapılan çalışmalar doğrultusunda ve klinik kullanımı açısından anlatmaya çalıştık.
In recent years, the use of complementary and traditional medicine has been increasing department of oncology. The benefit and importance of taking antioxidant supplements in cancer patients to reduce the oxidative damage in the body emphasized. We tried to explain the benefits of alpha lipoic acid, which has strong antioxidant, anti-inflammatory and apoptotic activity and is also given treatment of neuropathy in diabetic patients, its use in alternative medicine and the importance in the treatment of cancer patients, in line with the studies and in terms of clinical use.
Referanslar
Alpha-Lipoic Acid, Hiep Nguyen , Vikas Gupta, StatPearls Publishing; 2023. PMID: 33231971 Bookshelf ID: NBK564301.
Packer L, Witt EH, Tritschler HJ. Biyolojik bir antioksidan olarak alfa-Lipoik asit. Serbest Radik Biol Med. 1995; 19 (2):227-50.
Cureus. Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review. 2022; 14(6):e25750.
Vallianou N, Evangelopoulos A, Koutalas P. Alpha-lipoic Acid and diabetic neuropathy. Rev Diabet Stud. 2009 Winter;6(4):230-6.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790(10):1149-60.
Li G, Fu J, Zhao Y, Ji K, Luan T, Zang B. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Inflammation. 2015; 38(2):510-9.
Koh EH, Cho EH, Kim MS, Park JY, Lee KU. Effects of alpha-lipoic acid on AMP-activated protein kinase in different tissues: therapeutic implications for the metabolic syndrome. In: Patel MS, Packer L, editors. Lipoic Acid: Energy Production, Antioxidant Activity, and Health Effects. 2008. pp. 495–519.
Ziegler D. Painful diabetic neuropathy: advantage of novel drugs over old drugs? Diabetes Care. 2009;32(Suppl 2):S414–S419.
Maczurek AE, Krautwald M, Steele ML, et al. Lipoic acid as a novel treatment for mild cognitive impairment and early-stage Alzheimer’s disease. In: Packer L, Sies H, Eggersdorfer M, Cadenas E, editors. Micronutrients and Brain Health. 2009. pp. 133–147
Hong Y, Peng J, Cai X, Zhang X, Liao Y and Lan L (2017) Clinical efficacy of alprostadil combined with alpha‐lipoic acid in the treatment of elderly patients with diabetic nephropathy. Open Med (Wars) 12, 323–327.
Julia, M.; Dos, S.; Shikha, T.; Roberta, H.M. The Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications. J. Diabetes Res. 2019, 2019, 4189813.
Dias, V.; Junn, E.; Mouradian, M.M. The Role of Oxidative Stress in Parkinson’s Disease. J. Parkinson’s Dis. 2013, 3, 461–491
Yan, Z.; Baolu, Z. Oxidative Stress and the Pathogenesis of Alzheimer’s Disease. Oxid. Med. Cell. Longev. 2013, 2013, 316523.
Namaria, M.T.; Alexandru, L.A.; Monica, L.J.; Andreea, L.R.; Lorena, C. Oxidative stress as a potential target in acute kidney injury. Peer J. 2019, 7, e8046
Peipei Peng, Xiaojin Zhang, Tao Qi, Hao Cheng, Qiuyue Kong, Li Liu, Xiaofei Cao, Zhengnian Ding. FEBS Open Bio. 2020; 10(4):607-618.Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.
Bandana Chakravarti, Swati Rajput, Sana Raza, Sangam Rajak, Archana Tewari, Pratima Gupta, Aditya Upadhyay, Naibedya Chattopadhyay, Rohit Anthony Sinha. Biochim Biophys Acta Mol Basis Dis. 2022 1;1868(10):166455. Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness.
Dozio, E.; Ruscica, M.; Passafaro, L.; Dogliotti, G.; Steffani, L.; Pagani, A.; Demartini, G.; Esposti, D.; Fraschini, F.; Magni, P. The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur. J. Pharmacol. 2010, 641, 29–34.
Michikoshi, H.; Nakamura, T.; Sakai, K.; Suzuki, Y.; Adachi, E.; Matsugo, S.; Matsumoto, K. α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells. Cancer Lett. 2013, 335, 472–478.
Bashiri, T.; Mt, G.; Zavareh, S. Influence of alpha-lipoic acid on survival and proliferation of mesenchymal stem cells Abstract: Background: Mesenchymal stem cells (MSCs) contribute to tissue repair in vivo and form an attractive cell source for tissue engineering
Farhat, D.; Léon, S.; Ghayad, S.E.; Gadot, N.; Icard, P.; Le Romancer, M.; Hussein, N. Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation. Br. J. Cancer 2020, 1–10.
Na, M.H.; Seo, E.Y.; Kim, W.K. Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells. Nutr. Res. Pract. 2009, 3, 265.
Rehab H Werida, Reham A Elshafiey, Asser Ghoneim, Sherif Elzawawy, Tarek M Mostafa. Support Care Cancer. 2022; 30(9):7281-7292.Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
Wang XM, Lehky TJ, Brell JM, Dorsey SG. Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine. 2012;59(1):3–9. doi: 10.1016/j.cyto.2012.03.027.
Nishida K, Kuchiiwa S, Oiso S, Futagawa T, Masuda S, Takeda Y, Yamada K. Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. Cancer Sci. 2008;99(8):1618–1625. doi: 10.1111/j.1349-7006.2008.00877.
Volkova M, Russell R. Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr Cardiol Rev. 2011;7(4):214–220. doi: 10.2174/157340311799960645.
Syahrir M, Andayani YD, Djamaludin N, Maksudin ES, Muharramah PF, Rosyidi Kgs M, Haddani H, Bahar E. Efficacy of alpha lipoic acid supplementation in chemotherapy-induced peripheral neuropathy. Bioscientia Medicina: J Biomed Transl Res. 2020;5(1):94–98. doi: 10.32539/bsm.v5i1.162.
Kyung-Hee Kim, Byeonghyeon Lee, Ye-Ri Kim, Min-A Kim, Nari Ryu, Da Jung Jung, Un-Kyung Kim, Jeong-In Baek, Kyu-Yup Lee. Cell Death Dis. 2018; 9(8):827. Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity.
Int Immunopharmacol. 2021: 96:107741.The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review. Sahar Sheikholeslami, Shaghayegh Khodaverdian, Masoumeh Dorri-Giv, Seyyed Mohammad Hosseini, Shokoufeh Souri, Razzagh Abedi-Firouzjah, Hamed Zamani, Leila Dastranj, Bagher Farhood.
Azam Izadi , Mohammad Soukhtanloo, Farshad Mirzavi, Mohammad Jalili-Nik, Asie Sadeghi. Evid Based Complement Alternat Med. 2023 Jul 18:2023:8618575. Alpha-Lipoic Acid, Auraptene, and Particularly Their Combination Prevent the Metastasis of U87 Human Glioblastoma Cells.
Med Oncol. 2023; 15;40(8):244. Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression. Aybuke Celik, Filiz Bakar-Ates.
Volume 58, Issue 5. Seong Jin Lee, Jun Goo Kang, Ohk Hyun Ryu, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Dong-Sun Kim, Tae Wha Kim Effects of α-lipoic acid on transforming growth factor β1–p38 mitogen-activated protein kinase–fibronectin pathway in diabetic nephropathy.
Claudia Bellomo, Laia Caja and Aristidis Moustakas. Br J Cancer. 2016; 115(7): 761–769. Transforming growth factor β as regulator of cancer stemness and metastasis.
E. Dozio et al. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur. J. Pharmacol. (2010)
H.S. Lee et al. α-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutr. Res. (2010)
Life Sci. 2018; 15:207:15-22. α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling. Joytirmay Tripathy, Anindita Tripathy, Muthusamy Thangaraju, Mrutyunjay Suar, Selvakumar Elangovan.
Molecular and Cellular Endocrinology Volume 419, 5. Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells. Min Ji Jeon, Won Gu Kim, Seonhee Lim, Hyun-Jeung Choi, Soyoung Sim, Tae Yong Kim, Young Kee Shong, Won Bae Kim.trans.
B.J. Li1, X.Y. Hao1, G.H. Ren and Y. Gong. Effect of lipoic acid combined with paclitaxel on breast cancer cells.
Bratislava Medical Journal Vol.115, No.10, p.611-616, 2014.
Gebka A, Serkies-Minuth E, Raczyńska D. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm. 2014; 2014:131538.
Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21(2):114-21.
Tetikçok R, Özçetin M, Çeltek NY, Oktay G, Ünlü U, Şengül M. Lipoik Asit. 2015;5:206-9
Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Möller W, Tritschler HJ, Mehnert H. Diyabetik polinöropatinin antioksidan tioktik asit (alfa-lipoik asit) ile tedavisi: iki yıllık çok merkezli, randomize, çift kör plasebo- kontrollü çalışma (ALADIN II). Diyabetik Nöropatide Alfa Lipoik Asit. Serbest Radiç Res. 1999; 31 (3):171-9.
Cremer DR, Rabeler R, Roberts A, Lynch B. Safety evaluation of alpha-lipoic acid (ALA). Regul Toxicol Pharmacol. 2006; 46(1):29-41.
Phua, L.C., New, L.S., Goh, C.W. et al. Investigation of the Drug–Drug Interaction Between α-Lipoic Acid and Valproate via Mitochondrial β-oxidation. Pharm Res 25, 2639–2649 (2008).
Ardianto C, Wardani HA, Nurrahmi N, Rahmadi M, Khotib J.Vet World. 2020 May;13(5):963-966.Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice.
Al-Rasheed N.M, Fadda L, Al-Rasheed N.M, Hasan I.H, Ali H.M, Mohamad R.A. Hepatoprotective role of a-lipoic acid and thymoquinone in acetaminophen induced liver injury: Down-regulation of COX-2 and flt-1 expression. Braz. Arch. Biol. Technol. 2017;60(12):1–12
Packer L, Witt EH, Tritschler HJ. Biyolojik bir antioksidan olarak alfa-Lipoik asit. Serbest Radik Biol Med. 1995; 19 (2):227-50.
Cureus. Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review. 2022; 14(6):e25750.
Vallianou N, Evangelopoulos A, Koutalas P. Alpha-lipoic Acid and diabetic neuropathy. Rev Diabet Stud. 2009 Winter;6(4):230-6.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790(10):1149-60.
Li G, Fu J, Zhao Y, Ji K, Luan T, Zang B. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Inflammation. 2015; 38(2):510-9.
Koh EH, Cho EH, Kim MS, Park JY, Lee KU. Effects of alpha-lipoic acid on AMP-activated protein kinase in different tissues: therapeutic implications for the metabolic syndrome. In: Patel MS, Packer L, editors. Lipoic Acid: Energy Production, Antioxidant Activity, and Health Effects. 2008. pp. 495–519.
Ziegler D. Painful diabetic neuropathy: advantage of novel drugs over old drugs? Diabetes Care. 2009;32(Suppl 2):S414–S419.
Maczurek AE, Krautwald M, Steele ML, et al. Lipoic acid as a novel treatment for mild cognitive impairment and early-stage Alzheimer’s disease. In: Packer L, Sies H, Eggersdorfer M, Cadenas E, editors. Micronutrients and Brain Health. 2009. pp. 133–147
Hong Y, Peng J, Cai X, Zhang X, Liao Y and Lan L (2017) Clinical efficacy of alprostadil combined with alpha‐lipoic acid in the treatment of elderly patients with diabetic nephropathy. Open Med (Wars) 12, 323–327.
Julia, M.; Dos, S.; Shikha, T.; Roberta, H.M. The Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications. J. Diabetes Res. 2019, 2019, 4189813.
Dias, V.; Junn, E.; Mouradian, M.M. The Role of Oxidative Stress in Parkinson’s Disease. J. Parkinson’s Dis. 2013, 3, 461–491
Yan, Z.; Baolu, Z. Oxidative Stress and the Pathogenesis of Alzheimer’s Disease. Oxid. Med. Cell. Longev. 2013, 2013, 316523.
Namaria, M.T.; Alexandru, L.A.; Monica, L.J.; Andreea, L.R.; Lorena, C. Oxidative stress as a potential target in acute kidney injury. Peer J. 2019, 7, e8046
Peipei Peng, Xiaojin Zhang, Tao Qi, Hao Cheng, Qiuyue Kong, Li Liu, Xiaofei Cao, Zhengnian Ding. FEBS Open Bio. 2020; 10(4):607-618.Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.
Bandana Chakravarti, Swati Rajput, Sana Raza, Sangam Rajak, Archana Tewari, Pratima Gupta, Aditya Upadhyay, Naibedya Chattopadhyay, Rohit Anthony Sinha. Biochim Biophys Acta Mol Basis Dis. 2022 1;1868(10):166455. Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness.
Dozio, E.; Ruscica, M.; Passafaro, L.; Dogliotti, G.; Steffani, L.; Pagani, A.; Demartini, G.; Esposti, D.; Fraschini, F.; Magni, P. The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur. J. Pharmacol. 2010, 641, 29–34.
Michikoshi, H.; Nakamura, T.; Sakai, K.; Suzuki, Y.; Adachi, E.; Matsugo, S.; Matsumoto, K. α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells. Cancer Lett. 2013, 335, 472–478.
Bashiri, T.; Mt, G.; Zavareh, S. Influence of alpha-lipoic acid on survival and proliferation of mesenchymal stem cells Abstract: Background: Mesenchymal stem cells (MSCs) contribute to tissue repair in vivo and form an attractive cell source for tissue engineering
Farhat, D.; Léon, S.; Ghayad, S.E.; Gadot, N.; Icard, P.; Le Romancer, M.; Hussein, N. Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation. Br. J. Cancer 2020, 1–10.
Na, M.H.; Seo, E.Y.; Kim, W.K. Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells. Nutr. Res. Pract. 2009, 3, 265.
Rehab H Werida, Reham A Elshafiey, Asser Ghoneim, Sherif Elzawawy, Tarek M Mostafa. Support Care Cancer. 2022; 30(9):7281-7292.Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
Wang XM, Lehky TJ, Brell JM, Dorsey SG. Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine. 2012;59(1):3–9. doi: 10.1016/j.cyto.2012.03.027.
Nishida K, Kuchiiwa S, Oiso S, Futagawa T, Masuda S, Takeda Y, Yamada K. Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. Cancer Sci. 2008;99(8):1618–1625. doi: 10.1111/j.1349-7006.2008.00877.
Volkova M, Russell R. Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr Cardiol Rev. 2011;7(4):214–220. doi: 10.2174/157340311799960645.
Syahrir M, Andayani YD, Djamaludin N, Maksudin ES, Muharramah PF, Rosyidi Kgs M, Haddani H, Bahar E. Efficacy of alpha lipoic acid supplementation in chemotherapy-induced peripheral neuropathy. Bioscientia Medicina: J Biomed Transl Res. 2020;5(1):94–98. doi: 10.32539/bsm.v5i1.162.
Kyung-Hee Kim, Byeonghyeon Lee, Ye-Ri Kim, Min-A Kim, Nari Ryu, Da Jung Jung, Un-Kyung Kim, Jeong-In Baek, Kyu-Yup Lee. Cell Death Dis. 2018; 9(8):827. Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity.
Int Immunopharmacol. 2021: 96:107741.The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review. Sahar Sheikholeslami, Shaghayegh Khodaverdian, Masoumeh Dorri-Giv, Seyyed Mohammad Hosseini, Shokoufeh Souri, Razzagh Abedi-Firouzjah, Hamed Zamani, Leila Dastranj, Bagher Farhood.
Azam Izadi , Mohammad Soukhtanloo, Farshad Mirzavi, Mohammad Jalili-Nik, Asie Sadeghi. Evid Based Complement Alternat Med. 2023 Jul 18:2023:8618575. Alpha-Lipoic Acid, Auraptene, and Particularly Their Combination Prevent the Metastasis of U87 Human Glioblastoma Cells.
Med Oncol. 2023; 15;40(8):244. Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression. Aybuke Celik, Filiz Bakar-Ates.
Volume 58, Issue 5. Seong Jin Lee, Jun Goo Kang, Ohk Hyun Ryu, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Dong-Sun Kim, Tae Wha Kim Effects of α-lipoic acid on transforming growth factor β1–p38 mitogen-activated protein kinase–fibronectin pathway in diabetic nephropathy.
Claudia Bellomo, Laia Caja and Aristidis Moustakas. Br J Cancer. 2016; 115(7): 761–769. Transforming growth factor β as regulator of cancer stemness and metastasis.
E. Dozio et al. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur. J. Pharmacol. (2010)
H.S. Lee et al. α-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutr. Res. (2010)
Life Sci. 2018; 15:207:15-22. α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling. Joytirmay Tripathy, Anindita Tripathy, Muthusamy Thangaraju, Mrutyunjay Suar, Selvakumar Elangovan.
Molecular and Cellular Endocrinology Volume 419, 5. Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells. Min Ji Jeon, Won Gu Kim, Seonhee Lim, Hyun-Jeung Choi, Soyoung Sim, Tae Yong Kim, Young Kee Shong, Won Bae Kim.trans.
B.J. Li1, X.Y. Hao1, G.H. Ren and Y. Gong. Effect of lipoic acid combined with paclitaxel on breast cancer cells.
Bratislava Medical Journal Vol.115, No.10, p.611-616, 2014.
Gebka A, Serkies-Minuth E, Raczyńska D. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm. 2014; 2014:131538.
Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21(2):114-21.
Tetikçok R, Özçetin M, Çeltek NY, Oktay G, Ünlü U, Şengül M. Lipoik Asit. 2015;5:206-9
Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Möller W, Tritschler HJ, Mehnert H. Diyabetik polinöropatinin antioksidan tioktik asit (alfa-lipoik asit) ile tedavisi: iki yıllık çok merkezli, randomize, çift kör plasebo- kontrollü çalışma (ALADIN II). Diyabetik Nöropatide Alfa Lipoik Asit. Serbest Radiç Res. 1999; 31 (3):171-9.
Cremer DR, Rabeler R, Roberts A, Lynch B. Safety evaluation of alpha-lipoic acid (ALA). Regul Toxicol Pharmacol. 2006; 46(1):29-41.
Phua, L.C., New, L.S., Goh, C.W. et al. Investigation of the Drug–Drug Interaction Between α-Lipoic Acid and Valproate via Mitochondrial β-oxidation. Pharm Res 25, 2639–2649 (2008).
Ardianto C, Wardani HA, Nurrahmi N, Rahmadi M, Khotib J.Vet World. 2020 May;13(5):963-966.Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice.
Al-Rasheed N.M, Fadda L, Al-Rasheed N.M, Hasan I.H, Ali H.M, Mohamad R.A. Hepatoprotective role of a-lipoic acid and thymoquinone in acetaminophen induced liver injury: Down-regulation of COX-2 and flt-1 expression. Braz. Arch. Biol. Technol. 2017;60(12):1–12
Sayfalar
363-368
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Odabaşı Bükün H. Alfa Lipoik Asit. Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 363-8. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13946
