Akgünlük (Boswellia Serrata)
Özet
Geleneksel bitkisel ilaçlar ve bunların bitkisel bileşenleri üzerine artan araştırmalar, bunların çeşitli kanser türlerinde kemoterapiye yardımcı olarak tamamlayıcı olarak faydalı olduğunu kabul etmiştir. Boswellia serrata ağacının oleo-sakız reçinesi, çağlardan beri geleneksel olarak dini, kozmetik ve tıbbi amaçlarla kullanılan böyle bir halk ilacıdır. Bitkinin oleo-sakız reçinesi, geleneksel tıpta artrit, astım, kronik ağrı, bağırsak rahatsızlıkları ve diğer birçok hastalık gibi inflamatuar hastalıklar da dahil olmak üzere çeşitli rahatsızlıkların tedavisinde kullanılmıştır. Bu yazımız , B. serrata ve bileşenlerinin sitotoksik ve antitümör özelliklerine ilişkin genel bilgiler vermektedir.
Increasing research on traditional herbal medicines and their herbal components has recognized their usefulness as a complement to chemotherapy in various types of cancer. The oleo-gum resin of the Boswellia serrata tree is one such folk remedy that has been used traditionally for religious, cosmetic and medicinal purposes since ages. The oleo-gum resin of the plant has been used in traditional medicine to treat a variety of ailments, including inflammatory diseases such as arthritis, asthma, chronic pain, intestinal disorders, and many other diseases. This article provides general information about the cytotoxic and antitumor properties of B. serrata and its components.
Referanslar
Siddiqui Mz Boswellia serrata, a potential antiinflammatory agent: an overview. Indian j Pharm Sci. 2011;73(3):255-261. 11. Sharma a, Mann aS, gajbhiye V, Kharya MD Phcog Rev.: Plant Review Phytochemical Profile of Boswellia serrata: an overview. Pharmacogn Rev. 2007;1(1):131-142. 12. Türkiye ilaç ve Tıbbi Cihaz Kurumu. Tıbbi Bitki Monografları; Boswellia serrata. p.1-2.
Sharma a, Mann aS, gajbhiye V, Kharya MD Phcog Rev.: Plant Review Phytochemical Profile of Boswellia serrata: an overview. Pharmacogn Rev. 2007;1(1):131-142.
Türkiye ilaç ve Tıbbi Cihaz Kurumu. Tıbbi Bitki Monografları; Boswellia serrata. p.1-2.
MM Khalafalla , E. Abdelatef , EM Daffalla , AA Nassrallah , KA Aboul-Enein , DA Lightfoot , A. Cocchetto , HA El-Shemy Vernonia amygdalina'nın kök kültürlerinden antilösemi aktivitesi
LA Torre , F. Bray , RL Siegel , J. Ferlay , J. Lortet-Tieulent , A. Jemal Küresel kanser istatistikleri, 2012. CA
Y. Shao , CT Ho , CK Chin , V. Badmaev , W. Ma , MT Huang Boswellia serrata'dan elde edilen boswellik asitlerin kültürdeki insan lösemi HL-60 hücrelerine karşı inhibitör aktivitesi Planta Med. 64 (1998) s.328-331
Y. Jing, S. Nakajo, L. Xia, K. Nakaya, Q. Fang, S. Waxman, R. Han Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Leuk.Res..23(1999) pp.43-50
Z. Qi, G. Zhang, W. Zhu Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive Hunan Yi Ke Da Xue Bao, 24(1999),pp.23-25
R. Siegel, J. Ma, Z. Zou, A. Jemal Cancer statistics, 2014 CA Cancer j.clin.,64(2014),pp.9-29
B. Buchele, W. Zugmaier, A. Estrada, F. Genze, T. Syrovets, C. Paetz, B. Schneider, T. Simmet Characterization of 3-α-acetyl-11-keto-α-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo Planta Med.72(2006).pp.1285-1289
X. Pang, Z. Yi, X. Zhang, B. Sung, W. Qu, X. Lian, B.B. Aggarwal, M. Liu Acetyl-11-keto-b-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis Cancer Res.,69(2009),pp.5893-5900
J. Ferlay, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D.M. Parkin, D. Forman, F.G. Bray Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet] International Agency for Research on Cancer.,Lyon,France(2013)
G. Garcea, A.R. Dennison, W.P. Steward, D.P. Berry Chemoprevention of gastrointestinal malignancies ANZ J.Surg.,73(2003),pp.680-686
N. Sharma, B. Trope, T.O. Lipman Vitamin supplementation: what the gastroenterologist needs to know J.Clin.Gastroenterol.,38(2004),pp.844-854
M.V. Grau, J.R. Rees, J.A. Baron Chemoprevention in gastrointestinal cancers: current status Basic Cl,n.Pharmacol.Toxicol.,98(2006)pp.281-287
J.J. Liu, A. Nilsson, S. Oredsson, V. Badmaev, R.D. Duan Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway Int.J.Mol.Med.,10(2002),pp.501-505
V.R. Yadav, S. Prasad, B. Sung, J.G. Gelovani, S. Guha, S. Krishnan, B.B. Aggarwal Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers Int.J.Cancer,130(2012),pp.2176-2184
Y. Shen, M. Takahashi, H.M. Byun, A. Link, N. Sharma, F. Balaguer, H.C. Leung, C.R. Boland, A. Goel Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells Cancer Biol.Ther., 13(2012)pp.542-552
H.P. Liu, Z.H. Gao, S.X. Cui, Y. Wang, B.Y. Li, H.X. Lou, X.J. Qu Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC (Min/+) mice Int.J.Cancer,132(2013)pp.2667-2681
Suhail, W. Wu, A. Cao, F.G. Mondalek, K.M. Fung, P.T. Shih, Y.T. Fang, C. Woolley, G. Young, H.K. Lin Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells BMC Complement Altern.Med.11(2011),p.129
B. Park, B. Sung, V.R. Yadav, S.G. Cho, M. Liu, B.B. Aggarwal Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression Int.J.Cancer 129(2011) pp.23-33
S. Togni, G. Maramaldi, A. Bonetta, L. Giacomelli, F. Di Pierro Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial Eur.Rev.Med.Pharmacol.Sci., 19(2015) pp.1338-1344
R.F. Hoernlein, T. Orlikowsky, C. Zehrer, D. Niethammer, E.R. Sailer, T. Simmet, G.E. Dannecker, H.P. Ammon Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase IJ.Pharmacol.Exp.Ther.,288(1999)pp.613-619
A.B. Kunnumakkara, A.S. Nair, B. Sung, M.K. Pandey, B.B. Aggarwal Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1 Mol.Cancer Res.7(2009) pp. 118-128
S.S. Agrawal, S. Saraswati, R. Mathur, M. Pandey Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing MouseFood Chem. Toxicol., 49(2011) pp.1924-1934
S. Kirste, M. Treier, S.J. Wehrle, G. Becker, M. Abdel-Tawab, K. Gerbeth, M.J. Hug, B. Lubrich, A.L. Grosu, F. Momm Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial Cancer 117(2011) pp.3788-3795
Sharma a, Mann aS, gajbhiye V, Kharya MD Phcog Rev.: Plant Review Phytochemical Profile of Boswellia serrata: an overview. Pharmacogn Rev. 2007;1(1):131-142.
Türkiye ilaç ve Tıbbi Cihaz Kurumu. Tıbbi Bitki Monografları; Boswellia serrata. p.1-2.
MM Khalafalla , E. Abdelatef , EM Daffalla , AA Nassrallah , KA Aboul-Enein , DA Lightfoot , A. Cocchetto , HA El-Shemy Vernonia amygdalina'nın kök kültürlerinden antilösemi aktivitesi
LA Torre , F. Bray , RL Siegel , J. Ferlay , J. Lortet-Tieulent , A. Jemal Küresel kanser istatistikleri, 2012. CA
Y. Shao , CT Ho , CK Chin , V. Badmaev , W. Ma , MT Huang Boswellia serrata'dan elde edilen boswellik asitlerin kültürdeki insan lösemi HL-60 hücrelerine karşı inhibitör aktivitesi Planta Med. 64 (1998) s.328-331
Y. Jing, S. Nakajo, L. Xia, K. Nakaya, Q. Fang, S. Waxman, R. Han Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Leuk.Res..23(1999) pp.43-50
Z. Qi, G. Zhang, W. Zhu Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive Hunan Yi Ke Da Xue Bao, 24(1999),pp.23-25
R. Siegel, J. Ma, Z. Zou, A. Jemal Cancer statistics, 2014 CA Cancer j.clin.,64(2014),pp.9-29
B. Buchele, W. Zugmaier, A. Estrada, F. Genze, T. Syrovets, C. Paetz, B. Schneider, T. Simmet Characterization of 3-α-acetyl-11-keto-α-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo Planta Med.72(2006).pp.1285-1289
X. Pang, Z. Yi, X. Zhang, B. Sung, W. Qu, X. Lian, B.B. Aggarwal, M. Liu Acetyl-11-keto-b-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis Cancer Res.,69(2009),pp.5893-5900
J. Ferlay, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D.M. Parkin, D. Forman, F.G. Bray Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet] International Agency for Research on Cancer.,Lyon,France(2013)
G. Garcea, A.R. Dennison, W.P. Steward, D.P. Berry Chemoprevention of gastrointestinal malignancies ANZ J.Surg.,73(2003),pp.680-686
N. Sharma, B. Trope, T.O. Lipman Vitamin supplementation: what the gastroenterologist needs to know J.Clin.Gastroenterol.,38(2004),pp.844-854
M.V. Grau, J.R. Rees, J.A. Baron Chemoprevention in gastrointestinal cancers: current status Basic Cl,n.Pharmacol.Toxicol.,98(2006)pp.281-287
J.J. Liu, A. Nilsson, S. Oredsson, V. Badmaev, R.D. Duan Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway Int.J.Mol.Med.,10(2002),pp.501-505
V.R. Yadav, S. Prasad, B. Sung, J.G. Gelovani, S. Guha, S. Krishnan, B.B. Aggarwal Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers Int.J.Cancer,130(2012),pp.2176-2184
Y. Shen, M. Takahashi, H.M. Byun, A. Link, N. Sharma, F. Balaguer, H.C. Leung, C.R. Boland, A. Goel Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells Cancer Biol.Ther., 13(2012)pp.542-552
H.P. Liu, Z.H. Gao, S.X. Cui, Y. Wang, B.Y. Li, H.X. Lou, X.J. Qu Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC (Min/+) mice Int.J.Cancer,132(2013)pp.2667-2681
Suhail, W. Wu, A. Cao, F.G. Mondalek, K.M. Fung, P.T. Shih, Y.T. Fang, C. Woolley, G. Young, H.K. Lin Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells BMC Complement Altern.Med.11(2011),p.129
B. Park, B. Sung, V.R. Yadav, S.G. Cho, M. Liu, B.B. Aggarwal Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression Int.J.Cancer 129(2011) pp.23-33
S. Togni, G. Maramaldi, A. Bonetta, L. Giacomelli, F. Di Pierro Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial Eur.Rev.Med.Pharmacol.Sci., 19(2015) pp.1338-1344
R.F. Hoernlein, T. Orlikowsky, C. Zehrer, D. Niethammer, E.R. Sailer, T. Simmet, G.E. Dannecker, H.P. Ammon Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase IJ.Pharmacol.Exp.Ther.,288(1999)pp.613-619
A.B. Kunnumakkara, A.S. Nair, B. Sung, M.K. Pandey, B.B. Aggarwal Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1 Mol.Cancer Res.7(2009) pp. 118-128
S.S. Agrawal, S. Saraswati, R. Mathur, M. Pandey Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing MouseFood Chem. Toxicol., 49(2011) pp.1924-1934
S. Kirste, M. Treier, S.J. Wehrle, G. Becker, M. Abdel-Tawab, K. Gerbeth, M.J. Hug, B. Lubrich, A.L. Grosu, F. Momm Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial Cancer 117(2011) pp.3788-3795
Sayfalar
281-288
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Kars EŞ. Akgünlük (Boswellia Serrata). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 281-8. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13929
