Zencefil (Zingber Officinale)
Özet
Yemeklerde en çok kullanılan baharatlardan biri olan zencefil köksapının geleneksel tıpta birçok iyileştirici özelliği olduğu biliniyor. Tıbbi kullanımları mide bulantısı, kusma, karın rahatsızlıkları ve ishal gibi çeşitli mide-bağırsak rahatsızlıklarının tedavisinden artrit, romatizma, ağrı ve kas rahatsızlıklarının tedavisine ve çeşitli kardiyovasküler hastalıklar ve metabolik hastalıkların hafifletilmesine kadar uzanır. Zencefilin iyi belgelenmiş bu özelliklerine ek olarak, yakın zamanda yapılan bilimsel çalışmalar, çok çeşitli deneysel modellerde zencefilin aynı zamanda antikanser özelliklere de sahip olduğunu ortaya çıkarmıştır.
The rhizome of ginger, one of the most widely used spices in food, has been reputed to have many curative properties in traditional medicine. Its medicinal uses range from the treatment of various gastrointestinal ailments, such as nausea, vomiting, abdominal discomforts, and diarrhea, to the treatment of arthritis, rheumatism, pain, and muscle discomfort and to the alleviation of various cardiovascular diseases and metabolic diseases. In addition to these well-documented properties of ginger, recent scientific studies have revealed that ginger also possesses anticancer properties in a wide range of experimental models.
Referanslar
Capasso F, Gaginella TS, Grandolini G, Izzo AA (2003) Phytotherapy. A quick reference to herbal medicine. SpringerVerlag, Heidelberg .
Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM (2008) Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol 20: 436–440
Baliga MS, Haniadka R, Pereira MM, D’Souza JJ, Pallaty PL, Bhat HP, Popuri S (2011) Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Scinutr 51(6):499– 523
Rahmani AH (2014) Active ingredients of ginger as potential can- didates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol Pathophysiol Pharmacol 6(2): 125
Tuntiwechapikul, W., Taka, T., Songsomboon, C., Kaewtunjai, N., Imsumran, A., & Makonkawkeyoon, L. (2010). Ginger extract inhibits human telomerase reverse transcriptase and c‐Myc expression in A549 lung cancer cells. Journal of Medicinal Food, 13(6), 1347–1354
Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic sta- tus, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition, 65(4), 515–520
Lee, H. S., Seo, E. Y., Kang, N. E., & Kim, W. K. (2008). [6]-gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. The Journal of Nutritional Biochemistry, 19(5), 313–319
Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006b). The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta‐analysis. American Jour- nal of Obstetrics and Gynecology, 194(1), 95–99. https://doi.org/ 10.1016/j.ajog.2005.06.046
Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006a). The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta‐analysis. American Journal of Obstetrics & Gynecology, 194(1), 95–99. https://doi.org/10.1016/ j.ajog.2005.06.046
Marx, W., McCarthy, A. L., Ried, K., Vitetta, L., McKavanagh, D., Thomson, D., ... Isenring, L. (2014). Can ginger ameliorate chemotherapy‐induced nausea? Protocol of a randomized double blind, placebo‐controlled trial. BMC Complementary and Alternative Medicine, 14(1), 134. https://doi.org/10.1186/1472‐6882‐14‐134
The effect of ginger (Zingiber officinale) on chemotherapy‐ induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials
Mook ORF, Frederiks WM, van Noorden CJF. The role of gelatinases in colorectal cancer progression and metastasis. Biochem Biophys Acta 2004;1705:69–89.
Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, et al. [6]- Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2005;335: 300–8.
Dias, C. A. R., Moura, P. M. S. S., & D'Angeliz, C. E. M. (2011). A complexa interação entre radicais livres, suplementação e doenças. Revista Multidisciplinar das FIPMoc, 10, 34–43.
Machado, H., Nagem, T. J., Peters, V. M., Fonseca, C. S., & Oliveira, T. T. (2010). Flavonóides e seu potencial terapêutico. Boletim Do Centro de Biologia da Reprodução, 27(1/2), 33–3
Lin, A., & Karin, M. (2003). NF‐κB in cancer: A marked target. Seminars in Cancer Biology, 13(2), 107–114
Prasad, S., Tyagi, A.K. (2015). Ginger and its constituents: Role in preven- tion and treatment of gastrointestinal cancer. Gastroenterology Research and Practice, 2015, 142979, 1–11
Elkady, A. I., Hussein, R. A. E. H., Abu‐Zinadah, O. A. (2014b). Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. BioMed Research International, 2014, 260210, 1–16
Jeong CH, Bode AM, Pugliese A, et al.: [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res 2009;69:5584–5591
Lee SH, Cekanova M, Baek SJ: Multiple mechanisms are in- volved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol Carcinog 2008;47:197–208
Hung JY, Hsu Y, Li CT, et al.: 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT= mTOR pathway in human non-small cell lung cancer A549 cells. J Agric Food Chem 2009;57:9809–9816
Vemuri, S. K., Banala, R. R., Subbaiah, G. P. V., Srivastava, S. K., Reddy, A. V. G., & Malarvili, T. (2017). Anti‐cancer potential of a mix of natural extracts of turmeric, ginger and garlic: A cell‐based study. Egyptian Joural of Basic and Applied Science, 4, 332–344
Rondanelli, M., Fossari, F., Vecchio, V., Gasparri, C., Peroni, G., Spadaccini, D., Riva, A., Petrangolini, G., Iannello, G., Nichetti, M., Infantino, V., & Perna, S. (2020). Clinical trials on pain lowering effect of ginger: A narrative review. Phytotherapy Research, 34(11), 2843–2856
Kimura, Y., Ito, H. And Hatano, T.: Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity. Biol. Pharm. Bull., 33: 1977-1982 (2010).
Bruno Revol, Elodie Gautier-Veyret, Pharmacokinetic herb-drug interaction between ginger and crizotinib, British Journal of Clinical Pharmacology Volume 86, Issue 9 p. 1892-1893
Zick, S. M., Turgeon, D. K., Vareed, S. K., Ruffin, M. T., Litzinger, A. J., Wright, B. D., Alrawi, S., Normolle, D. P., Djuric, Z., & Brenner, D. E. (2011). Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prevention Research, 4(11), 1929–1937
Danwilai, K., Konmun, J., Sripanidkulchai, B.-O., & Subongkot, S. (2017). Antioxidant activity of ginger extract as a daily supplement in can- cer patients receiving adjuvant chemotherapy: A pilot study. Cancer Management and Research, 9, 11–18
Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM (2008) Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol 20: 436–440
Baliga MS, Haniadka R, Pereira MM, D’Souza JJ, Pallaty PL, Bhat HP, Popuri S (2011) Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Scinutr 51(6):499– 523
Rahmani AH (2014) Active ingredients of ginger as potential can- didates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol Pathophysiol Pharmacol 6(2): 125
Tuntiwechapikul, W., Taka, T., Songsomboon, C., Kaewtunjai, N., Imsumran, A., & Makonkawkeyoon, L. (2010). Ginger extract inhibits human telomerase reverse transcriptase and c‐Myc expression in A549 lung cancer cells. Journal of Medicinal Food, 13(6), 1347–1354
Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic sta- tus, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition, 65(4), 515–520
Lee, H. S., Seo, E. Y., Kang, N. E., & Kim, W. K. (2008). [6]-gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. The Journal of Nutritional Biochemistry, 19(5), 313–319
Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006b). The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta‐analysis. American Jour- nal of Obstetrics and Gynecology, 194(1), 95–99. https://doi.org/ 10.1016/j.ajog.2005.06.046
Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006a). The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta‐analysis. American Journal of Obstetrics & Gynecology, 194(1), 95–99. https://doi.org/10.1016/ j.ajog.2005.06.046
Marx, W., McCarthy, A. L., Ried, K., Vitetta, L., McKavanagh, D., Thomson, D., ... Isenring, L. (2014). Can ginger ameliorate chemotherapy‐induced nausea? Protocol of a randomized double blind, placebo‐controlled trial. BMC Complementary and Alternative Medicine, 14(1), 134. https://doi.org/10.1186/1472‐6882‐14‐134
The effect of ginger (Zingiber officinale) on chemotherapy‐ induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials
Mook ORF, Frederiks WM, van Noorden CJF. The role of gelatinases in colorectal cancer progression and metastasis. Biochem Biophys Acta 2004;1705:69–89.
Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, et al. [6]- Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2005;335: 300–8.
Dias, C. A. R., Moura, P. M. S. S., & D'Angeliz, C. E. M. (2011). A complexa interação entre radicais livres, suplementação e doenças. Revista Multidisciplinar das FIPMoc, 10, 34–43.
Machado, H., Nagem, T. J., Peters, V. M., Fonseca, C. S., & Oliveira, T. T. (2010). Flavonóides e seu potencial terapêutico. Boletim Do Centro de Biologia da Reprodução, 27(1/2), 33–3
Lin, A., & Karin, M. (2003). NF‐κB in cancer: A marked target. Seminars in Cancer Biology, 13(2), 107–114
Prasad, S., Tyagi, A.K. (2015). Ginger and its constituents: Role in preven- tion and treatment of gastrointestinal cancer. Gastroenterology Research and Practice, 2015, 142979, 1–11
Elkady, A. I., Hussein, R. A. E. H., Abu‐Zinadah, O. A. (2014b). Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. BioMed Research International, 2014, 260210, 1–16
Jeong CH, Bode AM, Pugliese A, et al.: [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res 2009;69:5584–5591
Lee SH, Cekanova M, Baek SJ: Multiple mechanisms are in- volved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol Carcinog 2008;47:197–208
Hung JY, Hsu Y, Li CT, et al.: 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT= mTOR pathway in human non-small cell lung cancer A549 cells. J Agric Food Chem 2009;57:9809–9816
Vemuri, S. K., Banala, R. R., Subbaiah, G. P. V., Srivastava, S. K., Reddy, A. V. G., & Malarvili, T. (2017). Anti‐cancer potential of a mix of natural extracts of turmeric, ginger and garlic: A cell‐based study. Egyptian Joural of Basic and Applied Science, 4, 332–344
Rondanelli, M., Fossari, F., Vecchio, V., Gasparri, C., Peroni, G., Spadaccini, D., Riva, A., Petrangolini, G., Iannello, G., Nichetti, M., Infantino, V., & Perna, S. (2020). Clinical trials on pain lowering effect of ginger: A narrative review. Phytotherapy Research, 34(11), 2843–2856
Kimura, Y., Ito, H. And Hatano, T.: Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity. Biol. Pharm. Bull., 33: 1977-1982 (2010).
Bruno Revol, Elodie Gautier-Veyret, Pharmacokinetic herb-drug interaction between ginger and crizotinib, British Journal of Clinical Pharmacology Volume 86, Issue 9 p. 1892-1893
Zick, S. M., Turgeon, D. K., Vareed, S. K., Ruffin, M. T., Litzinger, A. J., Wright, B. D., Alrawi, S., Normolle, D. P., Djuric, Z., & Brenner, D. E. (2011). Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prevention Research, 4(11), 1929–1937
Danwilai, K., Konmun, J., Sripanidkulchai, B.-O., & Subongkot, S. (2017). Antioxidant activity of ginger extract as a daily supplement in can- cer patients receiving adjuvant chemotherapy: A pilot study. Cancer Management and Research, 9, 11–18
Sayfalar
129-134
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Sever N. Zencefil (Zingber Officinale). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 129-34. Erişim adresi: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13899
