Bromelainin Nörolojik ve Nöropsikiyatrik Hastalıklar Üzerine Etkinliği
References
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Che, C.-T., & Zhang, H. Plant natural products for human health. International Journal of Molecular Sciences. 2019; 20(4), 830.
Colletti, A., Li, S., Marengo, M., et al. Recent advances and insights into bromelain processing, pharmacokinetics and therapeutic uses. Applied Sciences. 2021; 11(18), 8428.
Ramli, A. N. M., Manas, N. H. A., Hamid, A. A. A., et al. Comparative structural analysis of fruit and stem bromelain from Ananas comosus. Food Chemistry. 2018; 266, 183-191.
Hikisz, P., & Bernasinska-Slomczewska, J. Beneficial properties of bromelain. Nutrients. 2021; 13(12), 4313.
Ramli, A. N. M., Aznan, T. N. T., & Illias, R. M. Bromelain: from production to commercialisation. Journal of the Science of Food and Agriculture. 2017; 97(5), 1386-1395.
Zhou, W., Ye, C., Geng, L., et al. Purification and characterization of bromelain from pineapple (Ananas comosus L.) peel waste. Journal of Food Science. 2021; 86(2), 385-393.
Eraky, S. M., Ramadan, N. M., & El-Magd, N. F. A. Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway. International Journal of Biological Macromolecules. 2023; 227, 1119-1131.
Kumar, R., Kumar, R., Sharma, N., et al. Pharmacological evaluation of bromelain in mouse model of Alzheimer’s disease. Neurotoxicology. 2022; 90, 19-34.
Sancesario, G. M., Nuccetelli, M., Cerri, A., et al. Bromelain degrades Aβ1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients. Current Alzheimer Research. 2018; 15(7), 628-636.
Bertha, E. A., & Balázs, J. Subthreshold depression in adolescence: a systematic review. European Child & Adolescent Psychiatry. 2013; 22, 589-603.
Thapar, A., Eyre, O., Patel, V., et al. Depression in young people. The Lancet. 2022; 400(10352), 617-631.
Parasuraman, R., Jayamurali, D., Manoharan, N., et al. Neuroprotective effect of bromelain on BDNF-TRKB signalling pathway in chronic unpredictable stress-induced depression model. Beni-Suef University Journal of Basic and Applied Sciences. 2024; 13(1), 1-19.
Jauhar, S., Johnstone, M., & McKenna, P. J. Schizophrenia. Lancet. 2022; 399(10323), 473–486.
Van Os, J., Kenis, G., & Rutten, B. The environment and schizophrenia. Nature. 2010; 468, 203–212.
Karakuş G, Kocal Y, Sert D. Şizofreni: Etyoloji, klinik özellikler ve tedavi. Arşiv Kaynak Tarama Dergisi. 2017; 26(2), 251-267.
Ayilara, G. O., & Owoyele, B. V. Bromelain prevented the onset of psychotic behaviours in social-isolation model of schizophrenia by inhibiting astrogliosis and oxido-inflammatory damage in male and female mice. Nutrire. 2024; 49(2), 39.
Bayo-Olugbami, A. A., Oyewale, T. O., Akintoye, O. O., et al. Bromelain modulates behaviour, oxido-inflammation and cholinergic transmission in ketamine-induced schizophrenia-like model in female wistar rats. Pacific Journal of Medical Sciences. 2024; 25(2), 18-30.
Ay, S. & Evcik, D. Nöropatik ağrı ve tedavisi. Yeni Tıp Dergisi. 2007; 24(2), 70-74.
Top Kartı D, Seçil Y. (2024). Aile Hekimliğinde Nörolojik Hastalıklar. (1. Baskı). Ankara: Türkiye Klinikleri.
Bakare, A. O., & Owoyele, B. V. Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats. The Korean Journal of Pain. 2020; 33(1), 13-22.
Bakare, A. O., & Owoyele, B. V. Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 2020; 393(3), 457-467.
Bakare, A. O., & Owoyele, B. V. Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats. Scientific Reports. 2021; 11(1), 289.
Akbayır, E., Şen, M., Ay, U., et al. Parkinson hastalığının etyopatogenezi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2017; 7(13), 1-23.
Akbulut, G. Parkinson hastalığı ve tıbbi beslenme tedavisi. Dirim Tıp Dergisi. 2009; 84(2), 51-58.
Okkay, I. F., Okkay, U., Cicek, B., et al. Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson’s disease. Molecular Biology Reports. 2021; 48, 7711-7717.
Adu, T. S., & Mabandla, M. V. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metabolic Brain Disease. 2019; 34, 1557-1564.
Adu, T. S., & Mabandla, M. V. Effects of bromelain on striatal neuroinflammation in rat model of parkinsonism. Brain Disorders. 2021; 3, 100018.
Adu, T., Adu, O. T., & Mabandla, M. Effects of bromelain on noradrenaline release during anxiety-like behaviour following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Surgical Research. 2022; 4(2): 1-7.
Adu, T. S., & Mabandla, M. V. Effect of bromelain on BDNF level and memory deficit following intra-medial forebrain bundle 6-OHDA injection in rat model of Parkinsonism. Journal of Neurology & Neurophysiology. 2020; 11(7), 1-5.
Che, C.-T., & Zhang, H. Plant natural products for human health. International Journal of Molecular Sciences. 2019; 20(4), 830.
Colletti, A., Li, S., Marengo, M., et al. Recent advances and insights into bromelain processing, pharmacokinetics and therapeutic uses. Applied Sciences. 2021; 11(18), 8428.
Ramli, A. N. M., Manas, N. H. A., Hamid, A. A. A., et al. Comparative structural analysis of fruit and stem bromelain from Ananas comosus. Food Chemistry. 2018; 266, 183-191.
Hikisz, P., & Bernasinska-Slomczewska, J. Beneficial properties of bromelain. Nutrients. 2021; 13(12), 4313.
Ramli, A. N. M., Aznan, T. N. T., & Illias, R. M. Bromelain: from production to commercialisation. Journal of the Science of Food and Agriculture. 2017; 97(5), 1386-1395.
Zhou, W., Ye, C., Geng, L., et al. Purification and characterization of bromelain from pineapple (Ananas comosus L.) peel waste. Journal of Food Science. 2021; 86(2), 385-393.
Eraky, S. M., Ramadan, N. M., & El-Magd, N. F. A. Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway. International Journal of Biological Macromolecules. 2023; 227, 1119-1131.
Kumar, R., Kumar, R., Sharma, N., et al. Pharmacological evaluation of bromelain in mouse model of Alzheimer’s disease. Neurotoxicology. 2022; 90, 19-34.
Sancesario, G. M., Nuccetelli, M., Cerri, A., et al. Bromelain degrades Aβ1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients. Current Alzheimer Research. 2018; 15(7), 628-636.
Bertha, E. A., & Balázs, J. Subthreshold depression in adolescence: a systematic review. European Child & Adolescent Psychiatry. 2013; 22, 589-603.
Thapar, A., Eyre, O., Patel, V., et al. Depression in young people. The Lancet. 2022; 400(10352), 617-631.
Parasuraman, R., Jayamurali, D., Manoharan, N., et al. Neuroprotective effect of bromelain on BDNF-TRKB signalling pathway in chronic unpredictable stress-induced depression model. Beni-Suef University Journal of Basic and Applied Sciences. 2024; 13(1), 1-19.
Jauhar, S., Johnstone, M., & McKenna, P. J. Schizophrenia. Lancet. 2022; 399(10323), 473–486.
Van Os, J., Kenis, G., & Rutten, B. The environment and schizophrenia. Nature. 2010; 468, 203–212.
Karakuş G, Kocal Y, Sert D. Şizofreni: Etyoloji, klinik özellikler ve tedavi. Arşiv Kaynak Tarama Dergisi. 2017; 26(2), 251-267.
Ayilara, G. O., & Owoyele, B. V. Bromelain prevented the onset of psychotic behaviours in social-isolation model of schizophrenia by inhibiting astrogliosis and oxido-inflammatory damage in male and female mice. Nutrire. 2024; 49(2), 39.
Bayo-Olugbami, A. A., Oyewale, T. O., Akintoye, O. O., et al. Bromelain modulates behaviour, oxido-inflammation and cholinergic transmission in ketamine-induced schizophrenia-like model in female wistar rats. Pacific Journal of Medical Sciences. 2024; 25(2), 18-30.
Ay, S. & Evcik, D. Nöropatik ağrı ve tedavisi. Yeni Tıp Dergisi. 2007; 24(2), 70-74.
Top Kartı D, Seçil Y. (2024). Aile Hekimliğinde Nörolojik Hastalıklar. (1. Baskı). Ankara: Türkiye Klinikleri.
Bakare, A. O., & Owoyele, B. V. Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats. The Korean Journal of Pain. 2020; 33(1), 13-22.
Bakare, A. O., & Owoyele, B. V. Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 2020; 393(3), 457-467.
Bakare, A. O., & Owoyele, B. V. Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats. Scientific Reports. 2021; 11(1), 289.
Akbayır, E., Şen, M., Ay, U., et al. Parkinson hastalığının etyopatogenezi. Deneysel Tıp Araştırma Enstitüsü Dergisi. 2017; 7(13), 1-23.
Akbulut, G. Parkinson hastalığı ve tıbbi beslenme tedavisi. Dirim Tıp Dergisi. 2009; 84(2), 51-58.
Okkay, I. F., Okkay, U., Cicek, B., et al. Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson’s disease. Molecular Biology Reports. 2021; 48, 7711-7717.
Adu, T. S., & Mabandla, M. V. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metabolic Brain Disease. 2019; 34, 1557-1564.
Adu, T. S., & Mabandla, M. V. Effects of bromelain on striatal neuroinflammation in rat model of parkinsonism. Brain Disorders. 2021; 3, 100018.
Adu, T., Adu, O. T., & Mabandla, M. Effects of bromelain on noradrenaline release during anxiety-like behaviour following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Surgical Research. 2022; 4(2): 1-7.
Adu, T. S., & Mabandla, M. V. Effect of bromelain on BDNF level and memory deficit following intra-medial forebrain bundle 6-OHDA injection in rat model of Parkinsonism. Journal of Neurology & Neurophysiology. 2020; 11(7), 1-5.
Pages
63-74
Published
April 15, 2025
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