Endometriozisde Nöralterapi Yaklaşımı
Synopsis
Endometriozis, rahim boşluğu dışında endometriyal benzeri dokunun anormal büyümesiyle karakterize, üreme çağındaki kadınların %10-15'ini etkileyen kronik inflamatuar bir hastalıktır. Ağrı en yaygın semptomdur. Tedavi seçenekleri arasında sınırlı etkinliği ve yüksek nüks oranları olan cerrahi ve farmakoterapi yer alır. Semptom yönetimi için yaygın olarak kullanılan hormonal tedavilerin yan etkileri ve kontraseptif sonuçları olabilir, bu da endometriozis ile ilişkili infertiliteye katkıda bulunur, ağrı ve lezyonlar genellikle tedavi kesildikten sonra tekrar ortaya çıkar. Etiyolojik faktörler arasında immünolojik ve enflamatuar düzensizlik etkin bir rol oynamakta ve yeni terapötik stratejiler geliştirmek için ilginç bir hedefi temsil etmektedir. Hastalığın ilerlemesini etkili bir şekilde azaltmak, ağrı semptomlarını hafifletmek ve üreme kapasitesini koruyarak hastaların genel refahını iyileştirmek için bu bulguları klinik uygulamaya dönüştürmek için daha fazla çabaya ihtiyaç vardır. Nöralterapi temel olarak düşük dozlardaki lokal anesteziklerle (prokain/lidokain) vücudumuzdaki geniş bir yer kaplayan bir elektriksel ağ şeklindeki vejetatif (otonom) sinir sisteminin stimüle edilmesini ve regülasyonunu sağlayan alternatif bir tedavidir. Ağrı ile başvuran endometriozis hastasının, lokal şikayetlere yönelik tedavilerin dışında sistematik olarak değerlendirilip elektriksel ağda gerçekleşecek müdahalelerle daha iyi cevap alınabileceği görülmektedir.
Endometriosis is a chronic inflammatory disorder characterized by the abnormal growth of endometrial-like tissue outside the uterine cavity, affecting 10–15% of women of reproductive age. Pain is the most common symptom. Treatment options include surgery, which has limited effectiveness and high recurrence rates, and pharmacotherapy. Hormonal therapies, commonly used for symptom management, can have side effects and contraceptive outcomes, contributing to the infertility associated with endometriosis, with pain and lesions often reappearing after treatment cessation. Among its etiological factors, immunological and inflammatory dysregulation plays a significant role, representing an interesting target for developing new therapeutic strategies. More effort is needed to translate these findings into clinical practice to effectively reduce disease progression, alleviate pain symptoms and preserve the reproductive capacity, improving patients’ overall wellbeing. Neural therapy is a regulatory treatment that uses low concentrations of local anesthetics (procaine/lidocaine) to stimulate and regulate the vegetative (autonomic) nervous system, a vast electrical network in our body. It is important to recognize that a patient presenting with pain in endimetriosis may respond better to systematic, more effective interventions as opposed to treatments that focus on localized complaints.
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