Periodontitis ve Romatoid Artrit
Synopsis
Periodontal hastalıklar patojenlere karşı lokal ve sistemik konak cevabın değişmesiyle bazı sistemik hastalıkları etkilerler. Bu değişimin sistemik hastalıklar üzerinde olumsuz etkileri olabileceği gibi, bazı sistemik hastalıkların da periodontal hastalıklar üzerinde olumsuz etkileri olabilir. Romatoid artrit(RA) ve periodontitis arasındaki ilişki altlarında yatan yıkıcı mekanizmaların benzerliği nedeniyle 50 yılı aşkındır üzerinde çalışmalar yapılan bir konudur. Periodontitis ve RA kronik seyirli enflamatuvar hastalıklardır. Her iki hastalıkta da sitokin ve matris metalloproteinazların salınımını sağlayan enflamatuvar hücrelerin faaliyetiyle sert ve yumuşak doku kaybı meydana gelmektedir. RA, enflamatuvar süreçlere ek olarak tedavide kullanılan ilaçlar yoluyla periodontal dokular üzerinde etkili olabilmektedir. Periodontitis tedavisi de RA' nın klinik seyri üzerinde olumlu etkide bulunarak hastaların iyileşmesine yardımcı olabilir. Periodontitisin oluşturduğu sistemik etkilerin RA'nın sistemik bulgularını etkileme riskinden korunabilmeleri için RA hastalarının periodontal sağlığına dikkat etmesi büyük önem taşımaktadır.
Periodontal diseases affect some systemic diseases by changing the local and systemic host response to pathogens. While this change may have negative effects on systemic diseases, some systemic diseases may also have negative effects on periodontal disesases. The relationship between rheumatoid arthritis (RA) and periodontitis is a subject that has been studied for more than 50 years due to the similarity of their underlying destructive mechanisms. Periodontitis and RA are inflammatory diseases with a chronic course. In both diseases, hard and soft tissue loss occurs due to the action of inflammatory cells that release cytokines and matrix metalloproteinases. In addition to inflammatory processes, RA can have an effect on periodontal tissues through the drugs used in treatment.
Periodontitis treatment may also have a positive effect on the clinical course of RA and help patients recover. It is of great importance for RA patients to pay attention to their periodontal health in order to be protected from the risk of the systemic effects of periodontitis affecting the systemic findings of RA.
References
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Farquharson, D.; Butcher, J.P.; Culshaw, S. Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis. Mucosal Immunol. 2012, 5, 112–120
Feldmann, M.; Brennan, F.M.; Maini, R.N. Rheumatoid arthritis. Cell 1996, 85, 307–310
Rhodes, B.; Furnrohr, B.G.; Vyse, T.J. C-reactive protein in rheumatology: Biology and genetics. Nat. Rev. Rheumatol. 2011, 7, 282–289.
de Molon RS, Rossa C Jr, Thurlings RM, Cirelli JA, Koenders MI. Linkage of periodontitis and rheumatoid arthritis: current evidence and potential biological interactions. IJMS. 2019;20(18):4541-4635.
Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89 Suppl 1:S237-S248.
Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423, 356–361.
Edwards, C.J.; Cooper, C. Early environmental factors and rheumatoid arthritis. Clin. Exp. Immunol. 2006, 143, 1–5.
Hutchinson, D.; Moots, R. Cigarette smoking and severity of rheumatoid arthritis. Rheumatology 2001, 40,1426–1427.
Kallberg, H.; Padyukov, L.; Plenge, R.M.; Ronnelid, J.; Gregersen, P.K.; van der Helm-van Mil, A.H.; Toes, R.E.; Huizinga, T.W.; Klareskog, L.; Alfredsson, L.; et al. Gene-gene and gene-environment interactions involvingmHLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am. J. Hum. Genet. 2007, 80, 867–875.
Krutyhołowa A, Strzelec K, Dziedzic A, et al. Host and bacterial factors linking periodontitis and rheumatoid arthritis. Front Immunol. 2022;13:980805.
Nielen MMJ, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50(2):380-386.
van de Sande MGH, van de Sande MGH, de Hair MJH, et al. Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase. Ann Rheum Dis. 2011;70(5):772-777.
Brink M, Hansson M, Mathsson L, et al. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013;65(4):899-910.
MacGregor AJ, Snieder H, Rigby AS, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000;43(1):30-37.
González-Febles J, Sanz M. Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?. Periodontol 2000. 2021;87(1):181-203.
Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569-2581.
van der Heijde, D.M.F.M., van 't Hof, M.A., van Riel, P.L.C.M., Theunisse, H.A.M., Lubberts, E.W., van Leeuwen, M.A., van Rijswijk, M.H., van de Putte, L.B.A. (1990). Judging disease activity in clinical practice in rheumatoid arthritis. First step in the development of a 'disease activity score'. Ann Rheum Dis, 49: 916-920
Engstrom, M.; Eriksson, K.; Lee, L.; Hermansson, M.; Johansson, A.; Nicholas, A.P.; Gerasimcik, N.; Lundberg, K.; Klareskog, L.; Catrina, A.I.; et al. Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis. J. Transl. Med. 2018, 16, 214.
Vitkov, L.; Hannig, M.; Minnich, B.; Herrmann, M. Periodontal sources of citrullinated antigens and TLR agonists related to RA. Autoimmunity 2018, 51, 304–309.
Horta-Baas, G.; Romero-Figueroa, M.D.S.; Montiel-Jarquin, A.J.; Pizano-Zarate, M.L.; Garcia-Mena, J.; Ramirez-Duran, N. Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis. J. Immunol. Res. 2017, 2017, 4835189.
Jeong, Y.; Kim, J.W.; You, H.J.; Park, S.J.; Lee, J.; Ju, J.H.; Park, M.S.; Jin, H.; Cho, M.L.; Kwon, B.; et al. Gut Microbial Composition and Function are Altered in Patients with Early Rheumatoid Arthritis. J. Clin. Med.2019, 8, 693
Nogueira, A.R.; Shoenfeld,Y. Microbiome and autoimmune diseases: Cause and effect relationship. Curr.Opin. Rheumatol. 2019, 31, 471–474.
Mondal, S.; Thompson, P.R. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. Acc. Chem. Res. 2019, 52, 818–832.
Romero, V.; Fert-Bober, J.; Nigrovic, P.A.; Darrah, E.; Haque, U.J.; Lee, D.M.; van Eyk, J.; Rosen, A.; Andrade, F. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci. Transl. Med. 2013, 5, 209ra150
Mercado, F.; Marshall, R.I.; Klestov, A.C.; Bartold, P.M. Is there a relationship between rheumatoid arthritis and periodontal disease? J. Clin. Periodontol. 2000, 27, 267–272
Mercado, F.B.; Marshall, R.I.; Bartold, P.M. Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J. Clin. Periodontol. 2003, 30, 761–772
Golub, L.M.; Payne, J.B.; Reinhardt, R.A.; Nieman, G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical “two-hit” model. J. Dent. Res. 2006, 85, 102–105.
Wegner, N.; Wait, R.; Sroka, A.; Eick, S.; Nguyen, K.A.; Lundberg, K.; Kinloch, A.; Culshaw, S.; Potempa, J., Venables, P.J. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and malpha-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010, 62, 2662–2672.
Bendtzen K, Morling N, Fomsgaard A, et al. Association between HLA‐DR2 and production of tumour necrosis factor alpha and interleukin 1 by mononuclear cells activated by lipopolysaccharide. Scand J Immunol. 1988;28(5):599‐606.
Michalowicz BS, Diehl SR, Gunsolley JC, et al. Evidence of a substantial genetic basis for adult periodontitis. J Periodontol.2000;71(11):1699‐1707.
Dissick A, Redman RS, Jones M, et al. Association of periodontitis with rheumatoid arthritis:a pilot study. J Periodontol 2009;81:223–230.
Hajishengallis, G. Periodontitis: From microbial immune subversion to systemic inflammation. Nat. Rev.Immunol. 2015, 15, 30–44.
Konig, M.F.; Abusleme, L.; Reinholdt, J.; Palmer, R.J.; Teles, R.P.; Sampson, K.; Rosen, A.; Nigrovic, P.A.; Sokolove, J.; Giles, J.T.; et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci. Transl. Med. 2016, 8, 369ra176.
Gualtierotti, R.; Marzano, A.V.; Spadari, F.; Cugno, M. Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases. J. Clin. Med. 2018, 8, 21.
Schmalz, G.; Berisha, L.;Wendor , H.;Widmer, F.; Marcinkowski, A.; Teschler, H.; Sommerwerck, U.; Haak, R.; Kollmar, O.; Ziebolz, D. Association of time under immunosuppression and di erent immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation. Med. Oral Patol. Oral Cir. Bucal 2018, 23, e326–e334.
Groenewegen, H.; Bierman, W.F.W.; Delli, K.; Dijkstra, P.U.; Nesse, W.; Vissink, A.; Spijkervet, F.K.L. Severe periodontitis is more common in HIV- infected patients. J. Infect. 2019, 78, 171–177.
Pers J-O, Saraux A, Pierre R, Youinou P. Anti-TNF-alpha immuno- therapy is associated with increased gingival inflammation with- out clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol. 2008;79(9):1645-1651.
Ziebolz D, Rupprecht A, Schmickler J, et al. Association of differ- ent immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross-sectional study. J Periodontol. 2018;89(11):1310-1317.
Savioli C, Ribeiro ACM, Fabri GMC, et al. Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol. 2012;18(4):180-184.
Silvestre FJ, Silvestre-Rangil J, Bagán L, Bagán JV. Effect of nonsurgical periodontal treatment in patients with periodontitis and rheumatoid arthritis: A systematic review. Med Oral Patol Oral Cir Bucal. 2016;21(3):e349-e354. Published 2016 May 1. doi:10.4317/medoral.20974
Ribeiro J, Leão A, Novaes AB. Periodontal infection as a posible severity factor for rheumatoid arthritis. J Clin Periodontol. 2005;32:412–6.
Al-katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007;13:134–7.
Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol. 2009;80:535–40.
Pinho MN, Oliveira RD, Novaes AB Jr, Voltarelli JC. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J. 2009;20:355–64.
Ranade SB, Doiphode S. Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol. 2012;16:22–7
Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A. Periodontal treatment decreases levels of antibodies to Prophyromonas gingivalis and citrulline in patients with reumatoid arthritis and periodontitis. J Periodontol. 2013;84:e74–84.
Biyikoğlu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoğlu E. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int. 2013;33:2607–16
Monsarrat P, Vergnes JN, Cantagrel A, Algans N, Cousty S, Kémoun P. Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trail. Trials. 2013;14:253.
Kaur S, Bright R, Proudman SM, Bartold PM. Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(2):113-122.
Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA. Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):128-132.
Monsarrat P, Fernandez de Grado G, Constantin A, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: The ESPERA randomised controlled trial. Joint Bone Spine. 2019;86(5):600-609.
Farquharson, D.; Butcher, J.P.; Culshaw, S. Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis. Mucosal Immunol. 2012, 5, 112–120
Feldmann, M.; Brennan, F.M.; Maini, R.N. Rheumatoid arthritis. Cell 1996, 85, 307–310
Rhodes, B.; Furnrohr, B.G.; Vyse, T.J. C-reactive protein in rheumatology: Biology and genetics. Nat. Rev. Rheumatol. 2011, 7, 282–289.
de Molon RS, Rossa C Jr, Thurlings RM, Cirelli JA, Koenders MI. Linkage of periodontitis and rheumatoid arthritis: current evidence and potential biological interactions. IJMS. 2019;20(18):4541-4635.
Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89 Suppl 1:S237-S248.
Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423, 356–361.
Edwards, C.J.; Cooper, C. Early environmental factors and rheumatoid arthritis. Clin. Exp. Immunol. 2006, 143, 1–5.
Hutchinson, D.; Moots, R. Cigarette smoking and severity of rheumatoid arthritis. Rheumatology 2001, 40,1426–1427.
Kallberg, H.; Padyukov, L.; Plenge, R.M.; Ronnelid, J.; Gregersen, P.K.; van der Helm-van Mil, A.H.; Toes, R.E.; Huizinga, T.W.; Klareskog, L.; Alfredsson, L.; et al. Gene-gene and gene-environment interactions involvingmHLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am. J. Hum. Genet. 2007, 80, 867–875.
Krutyhołowa A, Strzelec K, Dziedzic A, et al. Host and bacterial factors linking periodontitis and rheumatoid arthritis. Front Immunol. 2022;13:980805.
Nielen MMJ, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50(2):380-386.
van de Sande MGH, van de Sande MGH, de Hair MJH, et al. Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase. Ann Rheum Dis. 2011;70(5):772-777.
Brink M, Hansson M, Mathsson L, et al. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013;65(4):899-910.
MacGregor AJ, Snieder H, Rigby AS, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000;43(1):30-37.
González-Febles J, Sanz M. Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?. Periodontol 2000. 2021;87(1):181-203.
Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569-2581.
van der Heijde, D.M.F.M., van 't Hof, M.A., van Riel, P.L.C.M., Theunisse, H.A.M., Lubberts, E.W., van Leeuwen, M.A., van Rijswijk, M.H., van de Putte, L.B.A. (1990). Judging disease activity in clinical practice in rheumatoid arthritis. First step in the development of a 'disease activity score'. Ann Rheum Dis, 49: 916-920
Engstrom, M.; Eriksson, K.; Lee, L.; Hermansson, M.; Johansson, A.; Nicholas, A.P.; Gerasimcik, N.; Lundberg, K.; Klareskog, L.; Catrina, A.I.; et al. Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis. J. Transl. Med. 2018, 16, 214.
Vitkov, L.; Hannig, M.; Minnich, B.; Herrmann, M. Periodontal sources of citrullinated antigens and TLR agonists related to RA. Autoimmunity 2018, 51, 304–309.
Horta-Baas, G.; Romero-Figueroa, M.D.S.; Montiel-Jarquin, A.J.; Pizano-Zarate, M.L.; Garcia-Mena, J.; Ramirez-Duran, N. Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis. J. Immunol. Res. 2017, 2017, 4835189.
Jeong, Y.; Kim, J.W.; You, H.J.; Park, S.J.; Lee, J.; Ju, J.H.; Park, M.S.; Jin, H.; Cho, M.L.; Kwon, B.; et al. Gut Microbial Composition and Function are Altered in Patients with Early Rheumatoid Arthritis. J. Clin. Med.2019, 8, 693
Nogueira, A.R.; Shoenfeld,Y. Microbiome and autoimmune diseases: Cause and effect relationship. Curr.Opin. Rheumatol. 2019, 31, 471–474.
Mondal, S.; Thompson, P.R. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. Acc. Chem. Res. 2019, 52, 818–832.
Romero, V.; Fert-Bober, J.; Nigrovic, P.A.; Darrah, E.; Haque, U.J.; Lee, D.M.; van Eyk, J.; Rosen, A.; Andrade, F. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci. Transl. Med. 2013, 5, 209ra150
Mercado, F.; Marshall, R.I.; Klestov, A.C.; Bartold, P.M. Is there a relationship between rheumatoid arthritis and periodontal disease? J. Clin. Periodontol. 2000, 27, 267–272
Mercado, F.B.; Marshall, R.I.; Bartold, P.M. Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J. Clin. Periodontol. 2003, 30, 761–772
Golub, L.M.; Payne, J.B.; Reinhardt, R.A.; Nieman, G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical “two-hit” model. J. Dent. Res. 2006, 85, 102–105.
Wegner, N.; Wait, R.; Sroka, A.; Eick, S.; Nguyen, K.A.; Lundberg, K.; Kinloch, A.; Culshaw, S.; Potempa, J., Venables, P.J. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and malpha-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010, 62, 2662–2672.
Bendtzen K, Morling N, Fomsgaard A, et al. Association between HLA‐DR2 and production of tumour necrosis factor alpha and interleukin 1 by mononuclear cells activated by lipopolysaccharide. Scand J Immunol. 1988;28(5):599‐606.
Michalowicz BS, Diehl SR, Gunsolley JC, et al. Evidence of a substantial genetic basis for adult periodontitis. J Periodontol.2000;71(11):1699‐1707.
Dissick A, Redman RS, Jones M, et al. Association of periodontitis with rheumatoid arthritis:a pilot study. J Periodontol 2009;81:223–230.
Hajishengallis, G. Periodontitis: From microbial immune subversion to systemic inflammation. Nat. Rev.Immunol. 2015, 15, 30–44.
Konig, M.F.; Abusleme, L.; Reinholdt, J.; Palmer, R.J.; Teles, R.P.; Sampson, K.; Rosen, A.; Nigrovic, P.A.; Sokolove, J.; Giles, J.T.; et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci. Transl. Med. 2016, 8, 369ra176.
Gualtierotti, R.; Marzano, A.V.; Spadari, F.; Cugno, M. Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases. J. Clin. Med. 2018, 8, 21.
Schmalz, G.; Berisha, L.;Wendor , H.;Widmer, F.; Marcinkowski, A.; Teschler, H.; Sommerwerck, U.; Haak, R.; Kollmar, O.; Ziebolz, D. Association of time under immunosuppression and di erent immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation. Med. Oral Patol. Oral Cir. Bucal 2018, 23, e326–e334.
Groenewegen, H.; Bierman, W.F.W.; Delli, K.; Dijkstra, P.U.; Nesse, W.; Vissink, A.; Spijkervet, F.K.L. Severe periodontitis is more common in HIV- infected patients. J. Infect. 2019, 78, 171–177.
Pers J-O, Saraux A, Pierre R, Youinou P. Anti-TNF-alpha immuno- therapy is associated with increased gingival inflammation with- out clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol. 2008;79(9):1645-1651.
Ziebolz D, Rupprecht A, Schmickler J, et al. Association of differ- ent immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross-sectional study. J Periodontol. 2018;89(11):1310-1317.
Savioli C, Ribeiro ACM, Fabri GMC, et al. Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol. 2012;18(4):180-184.
Silvestre FJ, Silvestre-Rangil J, Bagán L, Bagán JV. Effect of nonsurgical periodontal treatment in patients with periodontitis and rheumatoid arthritis: A systematic review. Med Oral Patol Oral Cir Bucal. 2016;21(3):e349-e354. Published 2016 May 1. doi:10.4317/medoral.20974
Ribeiro J, Leão A, Novaes AB. Periodontal infection as a posible severity factor for rheumatoid arthritis. J Clin Periodontol. 2005;32:412–6.
Al-katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007;13:134–7.
Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol. 2009;80:535–40.
Pinho MN, Oliveira RD, Novaes AB Jr, Voltarelli JC. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J. 2009;20:355–64.
Ranade SB, Doiphode S. Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol. 2012;16:22–7
Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A. Periodontal treatment decreases levels of antibodies to Prophyromonas gingivalis and citrulline in patients with reumatoid arthritis and periodontitis. J Periodontol. 2013;84:e74–84.
Biyikoğlu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoğlu E. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int. 2013;33:2607–16
Monsarrat P, Vergnes JN, Cantagrel A, Algans N, Cousty S, Kémoun P. Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trail. Trials. 2013;14:253.
Kaur S, Bright R, Proudman SM, Bartold PM. Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(2):113-122.
Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA. Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):128-132.
Monsarrat P, Fernandez de Grado G, Constantin A, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: The ESPERA randomised controlled trial. Joint Bone Spine. 2019;86(5):600-609.
Pages
63-74
Published
April 16, 2024
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Bıyıkoğlu B, Tekin T. Periodontitis ve Romatoid Artrit. In: Kesim S, editor. Güncel Periodontoloji Çalışmaları III (Bahar) [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 63-74. Available from: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/3052/chapter/13772
