Hurma (Phoenix Dactylifera)
Synopsis
Hurma, içerdiği yüksek antioksidanlar sayesinde serbest radikallerin sebep olduğu hücre hasarını azaltabilecek bir doğal kaynaktır. Antioksidanların kanser hücrelerinin oluşumunu ve yayılmasını engelleyici etkileri, hurmanın kanser tedavisi üzerindeki potansiyel etkilerini destekleyen önemli bir faktördür. Ayrıca hurmanın içerdiği fitokimyasalların, özellikle prosiyanidinlerin, kanser hücrelerine karşı inhibe edici etkileri üzerinde yapılan çalışmalar, hurmanın kanserle mücadelede etkin bir rol oynayabileceğini öne sürmektedir.
Geleneksel tıp ve tamamlayıcı tedavi yöntemleri, yüzyıllardır çeşitli kültürlerde kullanılan ve doğanın sunduğu şifalı bitkilerin sağlık üzerindeki etkilerine odaklanır. Hurma, Orta Doğu'dan Uzak Doğu'ya kadar birçok kültürde tıbbi ve besinsel amaçlar için kullanılmıştır. Geleneksel tıp, hurmanın kanserle mücadeledeki potansiyelini, antioksidan zengin içeriği ve besin değerlerine dayanarak destekler. Bu bağlamda, hurmanın kanser tedavisinde geleneksel yöntemlerle nasıl entegre edilebileceğini anlamak, modern tıpta alternatif tedavi yaklaşımlarının araştırılmasına önemli bir katkı sağlayabilir.
Date fruit, owing to its high antioxidants, serves as a natural source that can reduce cell damage caused by free radicals. The inhibitory effects of antioxidants on the formation and spread of cancer cells are significant factors supporting the potential impact of dates on cancer treatment. Additionally, studies on the inhibitory effects of phytochemicals, especially proanthocyanidins, found in dates against cancer cells, suggest that dates may play an effective role in combating cancer.
Traditional medicine and complementary treatment methods focus on the effects of medicinal plants provided by nature on health and have been utilized in various cultures for centuries. Dates have been used for medicinal and nutritional purposes in many cultures, from the Middle East to the Far East. Traditional medicine supports the potential of dates in cancer treatment based on its rich antioxidant content and nutritional values. Understanding how dates can be integrated into cancer treatment using traditional methods can contribute significantly to the exploration of alternative treatment approaches in modern medicine.
References
Aslan S, Şanlıer N, Hurmanın (Phoenix dactylifera) Bileşimi ve Antioksidan Özellikleri, Bes Diy Derg 2018;46(2):176-182 DOI: 10.33076/2018.BDD
Baliga S, Baliga V, Kandathil S. A Review of the Chemistry and Pharmacology of The Date Fruits (Phoenix Dactylifera L.). Food Res Int 2011;44:1812-1822.
El-Sohaimy SA, Hafez EE. Biochemical and nutritional characterization of date palm fruits (Phoenix Dactylifera L). J Appl Sci Res 2010;6:1060-1067.
Al-Shahib W, Marshall RJ. The fruit of the date palm: its possible use as the best food for the future? Int J Food Sci Nutr. 2003 Jul;54(4):247-259. doi: 10.1080/09637480120091982. PMID: 12850886.
Arem AE, Guido F, Behija SE, et al. Chemical and aroma volatile compositions of date palm (Phoenix dactylifera L.) fruits at three maturation stages. Food Chem 2011;127:1744–1754.
Ahmed IA, Ahmed WK. Chemical composition of date varieties as influenced by the stage of ripening. Food Chem 1995;54:305-309.
Aslam J, Khan SH, Khan SA. Quantification of water soluble vitamins in six date palm (Phoenix dactylifera L.) cultivar’s fruits growing in Dubai, United Arab Emirates, through high performance liquid chromatography. J Saudi Chem Soc 2011;17:9–16.
Guendez R, Kallithraka S, Makris DP, et al. An analytical survey of the polyphenols of seeds of varieties ofgrape (Vitis vinifera) cultivated in Greece: implications for exploitation as a source of value-added phytochemicals. Phytochem Anal. 2005 Jan-Feb;16(1):17-23. doi: 10.1002/pca.804. PMID: 15688951.
Afiq A, Abdul-Rahman R, Che-Man Y, et al. Date seed and date seed oil. Int Food Res J 2013;20(5):2035-2043.
Akbari M, Razavizadeh R, Mohebbi GH,et al. Oil characteristics and fatty acid profile of seeds from three varieties of date palm (Phoenix dactylifera) cultivars in Bushehr-Iran. Afr J Biotechnol 2012;11(57):12088. DOI:10.5897/AJB12.1084
Gu L, Kelm MA, Hammerstone JF, et al. Screening of foods containing proanthocyanidins and their structuralcharacterization using LC-MS/MS and thiolytic degradation. J Agric Food Chem. 2003 Dec 3;51(25):7513- 7521. doi: 10.1021/jf034815d. PMID: 14640607.
Mansouri A, Embarek G, Kokkalou E, et al. Phenolic profile and antioxidant activity of the algerian ripe date palm fruit (Phoenix Dactylifera). Food Chem 2005;89(3):411–420. doi:10.1016/j.foodchem. 2004.02.051
Tapas AR, Sakarkar, AM, Kakde, RB. Flavonoids as nutraceuticals: A review. Trop J Pharm Res 2008;7:1089–1099. DOI:10.4314/tjpr.v7i3.14693
Shivashankara KS, Isobe S, Al-Haq MI, et al. Fruit antioxidant activity, ascorbic acid, total phenol, quercetin,and carotene of Irwin mango fruits stored at low temperature after high electric field pretreatment. J Agric Food Chem. 2004 Mar 10;52(5):1281-1286. doi: 10.1021/jf030243l. PMID: 14995134.
Castenmiller JJ, West CE. Bioavailability and bioconversion of carotenoids. Annu Rev Nutr. 1998;18:19-38. doi: 10.1146/annurev.nutr.18.1.19. PMID: 9706217.
Taleb H, Maddocks SE, Morris RK, et al. Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.). J Ethnopharmacol. 2016 Dec 24;194:457- 468. doi: 10.1016/j.jep.2016.10.032. Epub 2016 Oct 10. PMID: 27729284.
Peterson J, Dwyer J. (1998) Flavonoids: dietary occurrence and biochemical activity. Nutr Res. 1998;18(12):1995–2018. DOI:10.1016/S0271- 5317(98)00169-9
Taleb H, Morris RK, Withycombe CE, et al. Date syrup-derived polyphenols attenuate angiogenic responsesand exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase- 2 expression in endothelial cells. Nutr Res. 2016 Jul;36(7):636-647. doi: 10.1016/j.nutres.2016.02.010. Epub 2016 Feb 22. PMID: 27333954.
Puri A, Sahai R, Singh KL, et al. Immunostimulant activity of dry fruits and plant materials used in indian traditional medical system for mothers after child birth and invalids. J Ethnopharmacol. 2000 Jul;71(1- 2):89-92. doi: 10.1016/s0378-8741(99)00181-6. PMID:10904150.
Rock, W, Rosenblat, M, Borochov-Neori , H et al. Effects of date (Phoenix dactylifera L., Medjool or Hallawi variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: A pilot study. J. Agric. Food Chem. 2009, 57, 8010–8017. [CrossRef] [PubMed]
Dammak I, Boudaya S, Abdallah, FB, et al. Date seed oil inhibits hydrogen peroxide-induced oxidative stressin normal human epidermal melanocytes. Connect. Tissue Res. 2009, 50, 330–335. [CrossRef] [PubMed]
Ines, D, Sonia B, Fatma BA, et al. Date seed oil inhibits hydrogen peroxide-induced oxidative stress in human epidermal keratinocytes. Int. J. Dermatol. 2010, 49, 262–268. [CrossRef] [PubMed]
Vayalil PK, Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae). J. Agric. Food Chem. 2002, 50, 610–617. [CrossRef] [PubMed]
Ishurd O, Kennedy JF. The anti-cancer activity of polysaccharide prepared from Libyan dates (Phoenixdactylifera L.). Carbohydr. Polym. 2005, 59, 531–535. [CrossRef]
Diab KA, Aboul-Ela EI. In vivo comparative studies on antigenotoxicity of date palm (Phoenix dactylifera L.) pits extract against DNA damage induced by N-nitroso- N-methylurea in mice. Toxicol. Int. 2012, 19, 279– 286. [CrossRef] [PubMed]
Saafi EB, Louedi M, Elfeki A, et al. Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver. Exp. Toxicol. Pathol. 2011, 63, 433–441. [CrossRef] [Pub-Med]
Yasin BR, El-Fawal HA, Mousa SA. Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. Int J Mol Sci. 2015 Dec 17;16(12):30075-30090. doi: 10.3390/ijms161226210. PMID: 26694370; PMCID: PMC4691153.
Oves M, Aslam M, Rauf MA, et al. Antimicrobial and anticancer activities of silver nanoparticles synthesized from the root hair extract of Phoenix dactylifera. Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:429- 443. doi: 10.1016/j.msec.2018.03.035. Epub 2018 Apr 4. Erratum in: Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111499. PMID: 29752116.
Banu H, Renuka N, Faheem SM, et al. Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells. Biol Trace Elem Res. 2018 Nov;186(1):122- 134. doi: 10.1007/s12011-018-1287-0. Epub 2018 Mar 18. PMID: 29552710.
Khan F, Ahmed F, Pushparaj PN, et al. Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest. PLoS One. 2016 Jul 21;11(7):e0158963. doi: 10.1371/journal.pone.0158963. PMID: 27441372; PMCID: PMC4956039.
Khan MA, Siddiqui S, Ahmad I, et al. Phytochemicals from Ajwa dates pulp extract induce apoptosis in human triple-negative breast cancer by inhibiting AKT/ mTOR pathway and modulating Bcl-2 family proteins. Sci Rep. 2021 May 14;11(1):10322. doi: 10.1038/s41598- 021-89420-z. PMID: 33990623; PMCID: PMC8121835.
Godugu K, El-Far AH, Al Jaouni S, et al. Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin without Compromising its Anticancer Efficacy in Breast Cancer. Molecules. 2020 Jun 3;25(11):2597. doi: 10.3390/ molecules25112597. Erratum in: Molecules. 2022 Dec 09;27(24): PMID: 32503143; PMCID: PMC7321378.
Zein N, Elewa YHA, Alruwaili MK, et al. Barhi date (Phoenix dactylifera) extract ameliorates hepatocellularcarcinoma in male rats. Biomed Pharmacother. 2022 Dec;156:113976. doi: 10.1016/j.biopha.2022.113976. Epub 2022 Nov 7. PMID: 36411668.
Siddiqui S, Ahmad R, Khan MA, et al. Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells. Sci Rep. 2019 Jan 21;9(1):245. doi: 10.1038/s41598-018-36475- 0. PMID: 30664656; PMCID: PMC6341075.
Khan F, Khan TJ, Kalamegam G, et al. Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. BMC Complement Altern Med. 2017 Aug 22;17(1):418. doi: 10.1186/s12906-017-1926-6. PMID: 28830415; PMCID: PMC5567468.
Raish M, Kalam MA, Ahmad A, et al. Eudragit-Coated Sporopollenin Exine Microcapsules (SEMC) of Phoenix dactylifera L. of 5-Fluorouracil for Colon-Specific Drug Delivery. Pharmaceutics. 2021 Nov 12;13(11):1921. doi: 10.3390/pharmaceutics13111921. PMID: 34834336; PMCID: PMC8621040.
Eid N, Osmanova H, Natchez C, et al. Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study. Br J Nutr. 2015 Oct 28;114(8):1226-1236. doi: 10.1017/S0007114515002780. PMID: 26428278.
Eid N, Enani S, Walton G, et al. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci. 2014 Oct 8;3:e46. doi: 10.1017/jns.2014.16. PMID: 26101614; PMCID: PMC4473134.
Al Alawi R, Alhamdani MSS, Hoheisel JD et al. Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer. Biomed Pharmacother. 2020 Jan;121:109522. doi: 10.1016/j.biopha.2019.109522. Epub 2019 Oct 29. PMID: 31675539.
Ghazzawy HS, Gouda MM, Awad NS, et al. Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells. Front Nutr. 2022 Oct 28;9:998929. doi: 10.3389/fnut.2022.998929. PMID: 36386915; PMCID: PMC9650284.
Mirza MB, Elkady AI, Al-Attar AM, et al. Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells. J Ethnopharmacol. 2018 May 23;218:35- 44. doi: 10.1016/j.jep.2018.02.030. Epub 2018 Feb 21. PMID: 29476962.
Chakroun M, Khemakhem B, Mabrouk HB, et al. Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L’s leaf: in vitro and in vivo approach. Biomed Pharmacother. 2016;84:415–422. https://doi.org/10.1016/j.biopha.2016.09.062
Baliga S, Baliga V, Kandathil S. A Review of the Chemistry and Pharmacology of The Date Fruits (Phoenix Dactylifera L.). Food Res Int 2011;44:1812-1822.
El-Sohaimy SA, Hafez EE. Biochemical and nutritional characterization of date palm fruits (Phoenix Dactylifera L). J Appl Sci Res 2010;6:1060-1067.
Al-Shahib W, Marshall RJ. The fruit of the date palm: its possible use as the best food for the future? Int J Food Sci Nutr. 2003 Jul;54(4):247-259. doi: 10.1080/09637480120091982. PMID: 12850886.
Arem AE, Guido F, Behija SE, et al. Chemical and aroma volatile compositions of date palm (Phoenix dactylifera L.) fruits at three maturation stages. Food Chem 2011;127:1744–1754.
Ahmed IA, Ahmed WK. Chemical composition of date varieties as influenced by the stage of ripening. Food Chem 1995;54:305-309.
Aslam J, Khan SH, Khan SA. Quantification of water soluble vitamins in six date palm (Phoenix dactylifera L.) cultivar’s fruits growing in Dubai, United Arab Emirates, through high performance liquid chromatography. J Saudi Chem Soc 2011;17:9–16.
Guendez R, Kallithraka S, Makris DP, et al. An analytical survey of the polyphenols of seeds of varieties ofgrape (Vitis vinifera) cultivated in Greece: implications for exploitation as a source of value-added phytochemicals. Phytochem Anal. 2005 Jan-Feb;16(1):17-23. doi: 10.1002/pca.804. PMID: 15688951.
Afiq A, Abdul-Rahman R, Che-Man Y, et al. Date seed and date seed oil. Int Food Res J 2013;20(5):2035-2043.
Akbari M, Razavizadeh R, Mohebbi GH,et al. Oil characteristics and fatty acid profile of seeds from three varieties of date palm (Phoenix dactylifera) cultivars in Bushehr-Iran. Afr J Biotechnol 2012;11(57):12088. DOI:10.5897/AJB12.1084
Gu L, Kelm MA, Hammerstone JF, et al. Screening of foods containing proanthocyanidins and their structuralcharacterization using LC-MS/MS and thiolytic degradation. J Agric Food Chem. 2003 Dec 3;51(25):7513- 7521. doi: 10.1021/jf034815d. PMID: 14640607.
Mansouri A, Embarek G, Kokkalou E, et al. Phenolic profile and antioxidant activity of the algerian ripe date palm fruit (Phoenix Dactylifera). Food Chem 2005;89(3):411–420. doi:10.1016/j.foodchem. 2004.02.051
Tapas AR, Sakarkar, AM, Kakde, RB. Flavonoids as nutraceuticals: A review. Trop J Pharm Res 2008;7:1089–1099. DOI:10.4314/tjpr.v7i3.14693
Shivashankara KS, Isobe S, Al-Haq MI, et al. Fruit antioxidant activity, ascorbic acid, total phenol, quercetin,and carotene of Irwin mango fruits stored at low temperature after high electric field pretreatment. J Agric Food Chem. 2004 Mar 10;52(5):1281-1286. doi: 10.1021/jf030243l. PMID: 14995134.
Castenmiller JJ, West CE. Bioavailability and bioconversion of carotenoids. Annu Rev Nutr. 1998;18:19-38. doi: 10.1146/annurev.nutr.18.1.19. PMID: 9706217.
Taleb H, Maddocks SE, Morris RK, et al. Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.). J Ethnopharmacol. 2016 Dec 24;194:457- 468. doi: 10.1016/j.jep.2016.10.032. Epub 2016 Oct 10. PMID: 27729284.
Peterson J, Dwyer J. (1998) Flavonoids: dietary occurrence and biochemical activity. Nutr Res. 1998;18(12):1995–2018. DOI:10.1016/S0271- 5317(98)00169-9
Taleb H, Morris RK, Withycombe CE, et al. Date syrup-derived polyphenols attenuate angiogenic responsesand exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase- 2 expression in endothelial cells. Nutr Res. 2016 Jul;36(7):636-647. doi: 10.1016/j.nutres.2016.02.010. Epub 2016 Feb 22. PMID: 27333954.
Puri A, Sahai R, Singh KL, et al. Immunostimulant activity of dry fruits and plant materials used in indian traditional medical system for mothers after child birth and invalids. J Ethnopharmacol. 2000 Jul;71(1- 2):89-92. doi: 10.1016/s0378-8741(99)00181-6. PMID:10904150.
Rock, W, Rosenblat, M, Borochov-Neori , H et al. Effects of date (Phoenix dactylifera L., Medjool or Hallawi variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: A pilot study. J. Agric. Food Chem. 2009, 57, 8010–8017. [CrossRef] [PubMed]
Dammak I, Boudaya S, Abdallah, FB, et al. Date seed oil inhibits hydrogen peroxide-induced oxidative stressin normal human epidermal melanocytes. Connect. Tissue Res. 2009, 50, 330–335. [CrossRef] [PubMed]
Ines, D, Sonia B, Fatma BA, et al. Date seed oil inhibits hydrogen peroxide-induced oxidative stress in human epidermal keratinocytes. Int. J. Dermatol. 2010, 49, 262–268. [CrossRef] [PubMed]
Vayalil PK, Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae). J. Agric. Food Chem. 2002, 50, 610–617. [CrossRef] [PubMed]
Ishurd O, Kennedy JF. The anti-cancer activity of polysaccharide prepared from Libyan dates (Phoenixdactylifera L.). Carbohydr. Polym. 2005, 59, 531–535. [CrossRef]
Diab KA, Aboul-Ela EI. In vivo comparative studies on antigenotoxicity of date palm (Phoenix dactylifera L.) pits extract against DNA damage induced by N-nitroso- N-methylurea in mice. Toxicol. Int. 2012, 19, 279– 286. [CrossRef] [PubMed]
Saafi EB, Louedi M, Elfeki A, et al. Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver. Exp. Toxicol. Pathol. 2011, 63, 433–441. [CrossRef] [Pub-Med]
Yasin BR, El-Fawal HA, Mousa SA. Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. Int J Mol Sci. 2015 Dec 17;16(12):30075-30090. doi: 10.3390/ijms161226210. PMID: 26694370; PMCID: PMC4691153.
Oves M, Aslam M, Rauf MA, et al. Antimicrobial and anticancer activities of silver nanoparticles synthesized from the root hair extract of Phoenix dactylifera. Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:429- 443. doi: 10.1016/j.msec.2018.03.035. Epub 2018 Apr 4. Erratum in: Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111499. PMID: 29752116.
Banu H, Renuka N, Faheem SM, et al. Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells. Biol Trace Elem Res. 2018 Nov;186(1):122- 134. doi: 10.1007/s12011-018-1287-0. Epub 2018 Mar 18. PMID: 29552710.
Khan F, Ahmed F, Pushparaj PN, et al. Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest. PLoS One. 2016 Jul 21;11(7):e0158963. doi: 10.1371/journal.pone.0158963. PMID: 27441372; PMCID: PMC4956039.
Khan MA, Siddiqui S, Ahmad I, et al. Phytochemicals from Ajwa dates pulp extract induce apoptosis in human triple-negative breast cancer by inhibiting AKT/ mTOR pathway and modulating Bcl-2 family proteins. Sci Rep. 2021 May 14;11(1):10322. doi: 10.1038/s41598- 021-89420-z. PMID: 33990623; PMCID: PMC8121835.
Godugu K, El-Far AH, Al Jaouni S, et al. Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin without Compromising its Anticancer Efficacy in Breast Cancer. Molecules. 2020 Jun 3;25(11):2597. doi: 10.3390/ molecules25112597. Erratum in: Molecules. 2022 Dec 09;27(24): PMID: 32503143; PMCID: PMC7321378.
Zein N, Elewa YHA, Alruwaili MK, et al. Barhi date (Phoenix dactylifera) extract ameliorates hepatocellularcarcinoma in male rats. Biomed Pharmacother. 2022 Dec;156:113976. doi: 10.1016/j.biopha.2022.113976. Epub 2022 Nov 7. PMID: 36411668.
Siddiqui S, Ahmad R, Khan MA, et al. Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells. Sci Rep. 2019 Jan 21;9(1):245. doi: 10.1038/s41598-018-36475- 0. PMID: 30664656; PMCID: PMC6341075.
Khan F, Khan TJ, Kalamegam G, et al. Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. BMC Complement Altern Med. 2017 Aug 22;17(1):418. doi: 10.1186/s12906-017-1926-6. PMID: 28830415; PMCID: PMC5567468.
Raish M, Kalam MA, Ahmad A, et al. Eudragit-Coated Sporopollenin Exine Microcapsules (SEMC) of Phoenix dactylifera L. of 5-Fluorouracil for Colon-Specific Drug Delivery. Pharmaceutics. 2021 Nov 12;13(11):1921. doi: 10.3390/pharmaceutics13111921. PMID: 34834336; PMCID: PMC8621040.
Eid N, Osmanova H, Natchez C, et al. Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study. Br J Nutr. 2015 Oct 28;114(8):1226-1236. doi: 10.1017/S0007114515002780. PMID: 26428278.
Eid N, Enani S, Walton G, et al. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci. 2014 Oct 8;3:e46. doi: 10.1017/jns.2014.16. PMID: 26101614; PMCID: PMC4473134.
Al Alawi R, Alhamdani MSS, Hoheisel JD et al. Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer. Biomed Pharmacother. 2020 Jan;121:109522. doi: 10.1016/j.biopha.2019.109522. Epub 2019 Oct 29. PMID: 31675539.
Ghazzawy HS, Gouda MM, Awad NS, et al. Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells. Front Nutr. 2022 Oct 28;9:998929. doi: 10.3389/fnut.2022.998929. PMID: 36386915; PMCID: PMC9650284.
Mirza MB, Elkady AI, Al-Attar AM, et al. Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells. J Ethnopharmacol. 2018 May 23;218:35- 44. doi: 10.1016/j.jep.2018.02.030. Epub 2018 Feb 21. PMID: 29476962.
Chakroun M, Khemakhem B, Mabrouk HB, et al. Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L’s leaf: in vitro and in vivo approach. Biomed Pharmacother. 2016;84:415–422. https://doi.org/10.1016/j.biopha.2016.09.062
Pages
179-186
Published
March 11, 2024
Copyright (c) 2024 Academician Publishing Book Portal
License
LicenseHow to Cite
1.
Doğan A. Hurma (Phoenix Dactylifera). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 179-86. Available from: https://www.omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13912
